Nicotinamide Mononucleotide (NMN): Difference between revisions

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!Outcome
!Outcome
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|Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men {{#pmid:31685720|pmid31685720|url=https://www.jstage.jst.go.jp/article/endocrj/67/2/67_EJ19-0313/_html/-char/en}}
|{{#pmid:31685720|#pmid_text}}
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* singe admission of up to 500 mg
* singe admission of up to 500 mg
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* admission was safe and well-tolerated
* admission was safe and well-tolerated
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|Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women <ref name="pmid33888596"/>
|{{#pmid:33888596|#pmid_text}}
|[[RCT]], 10 weeks
|[[RCT]], 10 weeks
* placebo (n=12)
* placebo (n=12)
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* improvement in muscle insulin sensitivity is clinically relevant and is similar to the improvement observed after ~10% weight loss
* improvement in muscle insulin sensitivity is clinically relevant and is similar to the improvement observed after ~10% weight loss
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|Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study {{#pmid:34238308|pmid34238308}}
|{{#pmid:34238308|#pmid_text}}
|[[RCT]], 6 weeks
|[[RCT]], 6 weeks
* placebo (n=12)
* placebo (n=12)
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* The improvement is muscle, not cardiac, related.
* The improvement is muscle, not cardiac, related.
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|The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial {{#pmid:36482258|pmid36482258}}
| {{#pmid:36482258|#pmid_text}}
|[[RCT]], 8.5 weeks (60 days)
|[[RCT]], 8.5 weeks (60 days)