Creatine: Difference between revisions

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Text replacement - "Orally Consumable Longevity Molecules" to "Orally Consumable Longevity Compounds"

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 ===Lifespan===
-In animal studies, creatine supplementation has been associated with a 9% increase in lifespan. Creatine-fed mice also demonstrated significantly better performance on neurobehavioral testing. While human trials are needed to confirm these findings, they suggest a potential benefit of creatine supplementation for longevity.
+[[File:Creatine mice lifespan.gif|thumb|Survival rate of wild type mice after starting 1% creatine submission beginning in the age of 365 days]]
+In animal studies, creatine supplementation has been associated with a 9% increase in lifespan. Creatine-fed mice also demonstrated significantly better performance on neurobehavioral testing. While human trials are needed to confirm these findings, they suggest a potential benefit of creatine supplementation for longevity. {{#pmid:17416441|pmid17416441}}
-{{#pmid:17416441|pmid17416441}}
+The average daily food intake for an adult female C57BL/6 mouse ranges from approximately 2.5 to 5 grams, with a typical weight of 20-25 grams. If we take the average food intake to be 3.75 grams, then a 1% inclusion of creatine in this diet corresponds to a creatine intake of 0.035 grams per day. To calculate the creatine dose in mg/kg, divide the creatine intake by the average weight of the mouse (assuming 22.5 grams), resulting in a dose of approximately 1555 mg/kg. Converting this mouse dose to a human equivalent dose (HED) using [[Allometric Scaling|allometric scaling]] with a conversion factor of 12.3, the HED is around 126 mg/kg. For a 75 kg human, this dose translates to about 9450 mg/day.
 === Muscle Mass, Strength, Bone and Body Composition ===
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 Additionally, creatine supplementation has shown potential benefits for heart failure patients engaged in rehabilitation programs, though results vary across studies. While more research is essential, current findings suggest that phosphocreatine administration and possibly creatine supplementation may support heart metabolism and health, especially during ischemic challenges. {{#pmid:33572884|pmid33572884}}
-==Potential Health Benefits==
-Creatine supplementation has been associated with various health benefits which may contribute to its potential role in promoting longevity. Here are some of the potential benefits:
-===Cardiovascular Health===
-Creatine supplementation has shown promise in enhancing cardiac muscle performance. In animal studies, creatine restored ATP levels under cardiac stress conditions and reduced markers of heart muscle exhaustion. Human studies, although limited, have also shown promising results in improving cardiac performance in patients with chronic congestive heart failure.
-===Blood Sugar Regulation===
-Creatine supplementation has shown potential in managing blood sugar levels by increasing the body's ability to utilize glucose as metabolic fuel. This is particularly beneficial for diabetic individuals. Studies have shown creatine supplementation alongside moderate exercise improves oral glucose tolerance test results, indicating creatine's potential benefit in blood sugar regulation.
 ==Potential Therapeutic Role==
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 ===Safety ===
-A double-blind placebo-controlled study conducted in 2020 evaluated creatine monohydrate supplementation's effect on various health indicators in resistance training practitioners. The participants were supplemented with 0.3 g/kg (24g for 80kg) per day creatine monohydrate for 7 days. The study found that creatine monohydrate supplementation promoted an increase in performance and body weight, without causing any adverse events. No modifications were observed in a panel of blood and urine health indicators including red and white blood cell parameters, blood lipid profile, metabolic and urine markers, hepatic and renal function, indicating the safety of creatine monohydrate supplementation for health{{#pmid:32597619|pmid32597619}}.
+Since creatine monohydrate became a popular dietary supplement in the early 1990s, over 1,000 studies have been conducted and billions of servings of creatine have been ingested. The only consistently reported side effect from creatine supplementation that has been described in the literature has been weight gain. Available short and long-term studies in healthy and diseased populations, from infants to the elderly, at dosages ranging from 0.3 to 0.8 g/kg/day for up to 5 years have consistently shown that creatine supplementation poses no adverse health risks and may provide a number of health and performance benefits. {{#pmid:28615996|pmid28615996}}
-Moreover, an evidence-based scientific evaluation has confirmed in 2021 that, when ingested at recommended dosages, creatine supplementation does not result in kidney damage and/or renal dysfunction in healthy individuals, does not cause dehydration or muscle cramping, and appears to be generally safe and potentially beneficial for children and adolescents{{#pmid:33557850|pmid33557850}}.
+Moreover, an evidence-based scientific evaluation has confirmed in 2021 that, when ingested at recommended dosages, creatine supplementation does not result in kidney damage and/or renal dysfunction in healthy individuals, does not cause dehydration or muscle cramping, and appears to be generally safe and potentially beneficial for children and adolescents{{#pmid:33557850|pmid33557850}}. The followig misconceptions associated with creatine supplementation were adressed:
-===Misconceptions===
-Based on a scientific evaluation in 2021 {{#pmid:33557850|pmid33557850}}, it's important to address certain misconceptions associated with creatine supplementation:
 *Creatine supplementation does not always lead to water retention.
 *Creatine is not an anabolic steroid.
-* The majority of available evidence does not support a link between creatine supplementation and hair loss/baldness.
+*The majority of available evidence does not support a link between creatine supplementation and hair loss/baldness.
 *Creatine supplementation does not cause dehydration or muscle cramping.
 *Creatine supplementation does not increase fat mass.
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 The recommended dosage may also vary depending on the form of creatine being used. For example, other forms of creatine like Creatine Hydrochloride (HCL) or Creatine Ethyl Ester (CEE) might require different dosages compared to Creatine Monohydrate.
+=== Clearance ===
+Research has shown that once creatine stores in the muscle are elevated, it generally takes 4–6 weeks for creatine stores to return to baseline. {{#pmid:28615996|pmid28615996}}
 ===Efficacy===
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 *[[Wikipedia:Creatine|Wikipedia article]]
+== Todo ==
+* https://journals.lww.com/nsca-jscr/fulltext/2022/09000/efficacy_of_alternative_forms_of_creatine.42.aspx
+* Write something about stability
 ==References==
 <references />
-[[Category:Orally Consumable Longevity Molecules]]
+[[Category:Orally Consumable Longevity Compounds]]