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Bioavailability: Difference between revisions
→Measuring Bioavailability
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*'''For Pharmaceuticals''': In medication, high bioavailability ensures that a drug can effectively target the intended site in the body. | *'''For Pharmaceuticals''': In medication, high bioavailability ensures that a drug can effectively target the intended site in the body. | ||
*'''For Nutraceuticals''': In dietary supplements, it determines how well a nutrient is absorbed and utilized by the body. | *'''For Nutraceuticals''': In dietary supplements, it determines how well a nutrient is absorbed and utilized by the body. | ||
==Factors Affecting Bioavailability== | ==Factors Affecting Bioavailability== | ||
Several factors can influence the bioavailability of a substance: | Several factors can influence the bioavailability of a substance: | ||
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*'''Solubility''': Water-soluble compounds tend to have higher bioavailability than fat-soluble ones. | *'''Solubility''': Water-soluble compounds tend to have higher bioavailability than fat-soluble ones. | ||
*'''Interactions''': Interactions with other substances, like food or other drugs, can enhance or hinder absorption. | *'''Interactions''': Interactions with other substances, like food or other drugs, can enhance or hinder absorption. | ||
==Measuring Bioavailability== | ==Measuring Bioavailability== | ||
Bioavailability is often assessed through specific pharmacokinetic studies, which evaluate the concentration of a drug in plasma over time. Two key metrics used are: | Bioavailability is often assessed through specific pharmacokinetic studies, which evaluate the concentration of a drug in plasma over time. Two key metrics used are: | ||
*'''Absolute Bioavailability''': This measures the bioavailability of a drug compared to its intravenous administration. It is calculated as the ratio of the [[Area Under the Curve (AUC)|area under the curve (AUC)]] of the plasma concentration-time profile after non-intravenous administration to the AUC after intravenous administration. | *'''Absolute Bioavailability''': This measures the bioavailability of a drug compared to its intravenous administration. It is calculated as the ratio of the [[Area Under the Curve (AUC)|area under the curve (AUC)]] of the plasma concentration-time profile after non-intravenous administration to the AUC after intravenous administration. | ||
*'''Relative Bioavailability''': This compares the bioavailability of a drug in different formulations. | *'''Relative Bioavailability''': This compares the bioavailability of a drug in different formulations. | ||
== Improving Bioavailability== | == Improving Bioavailability== | ||
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*'''Chemical Modifications''': Altering the chemical structure of a compound can increase its solubility and absorption. | *'''Chemical Modifications''': Altering the chemical structure of a compound can increase its solubility and absorption. | ||
*'''Combinational Approaches''': Using adjuvants or combining nutrients with enhancers can improve bioavailability. | *'''Combinational Approaches''': Using adjuvants or combining nutrients with enhancers can improve bioavailability. | ||
==Conclusion== | ==Conclusion== | ||
Understanding and optimizing bioavailability is fundamental for the effectiveness of drugs and nutritional supplements. As research progresses, new methods and formulations continue to emerge, enhancing the efficacy of therapeutic and nutritional interventions. | Understanding and optimizing bioavailability is fundamental for the effectiveness of drugs and nutritional supplements. As research progresses, new methods and formulations continue to emerge, enhancing the efficacy of therapeutic and nutritional interventions. | ||
==See Also== | ==See Also== | ||
*Wikipedia - [[Wikipedia:Bioavailability|Bioavailability]] | *Wikipedia - [[Wikipedia:Bioavailability|Bioavailability]] | ||