Bioavailability: Difference between revisions

Bioavailability (view source)

Revision as of 14:00, 12 November 2023

559 bytes added , 12 November 2023

no edit summary

VisualWikitext

Strimo

Bureaucrats, Administrators

2,851

edits

@@ Line 15: / Line 15: @@
 *'''Interactions''': Interactions with other substances, like food or other drugs, can enhance or hinder absorption.
-==Measuring Bioavailability==
+== Measuring Bioavailability ==
-Bioavailability is often assessed through specific pharmacokinetic studies, which evaluate the concentration of a drug in plasma over time. Two key metrics used are:
+Bioavailability is often assessed through specific pharmacokinetic studies, which evaluate the concentration of a drug in plasma over time. The two key metrics used are absolute and relative bioavailability.
-*'''Absolute Bioavailability''': This measures the bioavailability of a drug compared to its intravenous administration. It is calculated as the ratio of the [[Area Under the Curve (AUC)|area under the curve (AUC)]] of the plasma concentration-time profile after non-intravenous administration to the AUC after intravenous administration.
-*'''Relative Bioavailability''': This compares the bioavailability of a drug in different formulations.
+* '''Absolute Bioavailability''': This measures the bioavailability of a drug compared to its intravenous administration. The formula for calculating absolute bioavailability (F) is:
+<math>F = \frac{AUC_{\text{oral}} \times Dose_{\text{IV}}}{AUC_{\text{IV}} \times Dose_{\text{oral}}} \times 100\%</math>
+where AUC is the area under the plasma concentration-time curve for oral (AUC<sub>oral</sub>) and intravenous (AUC<sub>IV</sub>) administration, and Dose refers to the dose administered via each route.
+* '''Relative Bioavailability''': This compares the bioavailability of a drug in different formulations, usually against a standard. The formula is:
+<math>F_{\text{rel}} = \frac{AUC_{\text{test}} \times Dose_{\text{ref}}}{AUC_{\text{ref}} \times Dose_{\text{test}}} \times 100\%</math>
+where AUC<sub>test</sub> and AUC<sub>ref</sub> are the areas under the curve for the test and reference formulations, respectively, and Dose is the dose for each.
 == Improving Bioavailability==