Area Under the Curve (AUC): Difference between revisions

← Older edit

Area Under the Curve (AUC) (view source)

Revision as of 20:52, 12 November 2023

501 bytes removed , 12 November 2023

no edit summary

VisualWikitext

Strimo

Bureaucrats, Administrators

2,869

edits

@@ Line 1: / Line 1: @@
+[[File:AUC.png|right|frameless]]
 The '''Area Under the Curve''' ('''AUC''') is a critical parameter in pharmacokinetics, representing the integral of the drug concentration-time curve. It quantifies the total drug exposure over time, providing vital information on drug absorption, distribution, metabolism, and elimination.
@@ Line 8: / Line 9: @@
 AUC offers insight into the extent and rate of drug absorption, making it a fundamental measure to assess bioavailability and bioequivalence of drugs.
-===Types of AUC===
-Several types of AUC values exist, each serving unique purposes in pharmacokinetic studies:
-*'''<math>\text{AUC}_{\text{last}}</math>''': Represents the AUC from the time of administration up to the last measurable concentration.
-*'''<math>\text{AUC}_{0\to\infty}</math>''': Represents the total AUC from the time of administration extrapolated to infinity.
-*'''<math>\text{AUC}_{0\to t}</math>''': Represents the AUC from the time of administration up to a specific time 't'.
-*'''<math>\text{AUC}_{\tau}</math>''': Represents the AUC over a dosing interval 'tau'.
-===Application===
-AUC is indispensable in pharmacology and drug development:
-*It is pivotal for determining the dosage and frequency of drug administration.
-*It aids in evaluating the bioequivalence of generic drugs to brand-name counterparts.
-*It enables researchers to study the pharmacokinetics of new drug candidates.
-===See Also===
-*Pharmacokinetics
-*Drug Metabolism
-*Bioavailability
-*Bioequivalence
-==References==
-<!-- Include references here -->
 ==Types of AUC==
@@ Line 63: / Line 41: @@
 |Suitable for studying the pharmacokinetics of drugs at subtherapeutic, micro-level doses.
 |}
+===Application===
+AUC is indispensable in pharmacology and drug development:
+*It is pivotal for determining the dosage and frequency of drug administration.
+*It aids in evaluating the bioequivalence of generic drugs to brand-name counterparts.
+*It enables researchers to study the pharmacokinetics of new drug candidates.
+===See Also===
+* [[Wikipedia:Area under the curve (pharmacokinetics)|Wikipedia article]]
+*[[Pharmacokinetics]]
+*[[Bioavailability]]
+*[[Bioequivalence]]
+[[Category:Pharmacokinetics]]