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Bioavailability: Difference between revisions
→Factors Affecting Bioavailability
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|The fraction of a micronutrient or drug that becomes available from its food matrix or dosage form in the GIT. | |The fraction of a micronutrient or drug that becomes available from its food matrix or dosage form in the GIT. | ||
|Physical and chemical form of the substance, processing methods, interactions with other components. | |Physical and chemical form of the substance, processing methods, interactions with other components. | ||
| | |Reduced liberation of [[Vitamin B12 (Cobalamin)|vitamin B12]] from food sources in the elderly due to decreased stomach acid production, impacting the release and subsequent absorption of B12. | ||
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|'''F<sub>B</sub>''' | |'''F<sub>B</sub>''' | ||
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|The fraction of the substance that passes through the intestinal wall into the systemic circulation. | |The fraction of the substance that passes through the intestinal wall into the systemic circulation. | ||
|Gastrointestinal mucosa integrity, presence of transporters and enzymes, physicochemical properties of the substance. | |Gastrointestinal mucosa integrity, presence of transporters and enzymes, physicochemical properties of the substance. | ||
|Absorption of | |Absorption of [[Coenzyme Q10 (CoQ10)]] is generally low due to its large molecular weight and fat solubility, making it better absorbed when taken with meals rich in fats. | ||
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|'''F<sub>M</sub>''' | |'''F<sub>M</sub>''' | ||
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|The fraction of the substance that remains in a bioactive form after metabolic transformations. | |The fraction of the substance that remains in a bioactive form after metabolic transformations. | ||
|Enzymatic activity within the GIT, liver metabolism, systemic circulation, metabolic stability, and enzymatic degradation susceptibility. | |Enzymatic activity within the GIT, liver metabolism, systemic circulation, metabolic stability, and enzymatic degradation susceptibility. | ||
| | |[[Resveratrol]] is rapidly metabolized in the liver into various metabolites, which may have reduced biological activity compared to the parent compound, affecting its overall bioavailability and potential health benefits. | ||
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