Isoleucine: Difference between revisions
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Isoleucine, one of the nine essential amino acids, is a branched-chain amino acid (BCAA) that is crucial for protein synthesis and energy production. It is not synthesized by the human body and must be obtained through diet. Sources of isoleucine include meat, fish, poultry, eggs, dairy products, nuts, seeds, and legumes. | |||
In the human body, isoleucine is involved in muscle metabolism and is heavily concentrated in muscle tissue. It is also significant in hemoglobin synthesis and regulation of blood sugar and energy levels. Isoleucine's role as a BCAA makes it vital for repairing muscle tissue, especially after exercise, and in the maintenance of healthy muscle mass, which tends to decline with age. | |||
== Isoleucine and Longevity == | |||
[[Category: Amino Acids]] | |||
[[Category: Longevity]] | |||
== Todo == | == Todo == | ||
Revision as of 07:07, 1 December 2023
Isoleucine, one of the nine essential amino acids, is a branched-chain amino acid (BCAA) that is crucial for protein synthesis and energy production. It is not synthesized by the human body and must be obtained through diet. Sources of isoleucine include meat, fish, poultry, eggs, dairy products, nuts, seeds, and legumes.
In the human body, isoleucine is involved in muscle metabolism and is heavily concentrated in muscle tissue. It is also significant in hemoglobin synthesis and regulation of blood sugar and energy levels. Isoleucine's role as a BCAA makes it vital for repairing muscle tissue, especially after exercise, and in the maintenance of healthy muscle mass, which tends to decline with age.
Isoleucine and Longevity
Todo
- 2023, Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice [1]
References
- ↑ Green CL et al.: Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice. Cell Metab 2023. (PMID 37939658) [PubMed] [DOI] [Full text] Low-protein diets promote health and longevity in diverse species. Restriction of the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine recapitulates many of these benefits in young C57BL/6J mice. Restriction of dietary isoleucine (IleR) is sufficient to promote metabolic health and is required for many benefits of a low-protein diet in C57BL/6J males. Here, we test the hypothesis that IleR will promote healthy aging in genetically heterogeneous adult UM-HET3 mice. We find that IleR improves metabolic health in young and old HET3 mice, promoting leanness and glycemic control in both sexes, and reprograms hepatic metabolism in a sex-specific manner. IleR reduces frailty and extends the lifespan of male and female mice, but to a greater degree in males. Our results demonstrate that IleR increases healthspan and longevity in genetically diverse mice and suggests that IleR, or pharmaceuticals that mimic this effect, may have potential as a geroprotective intervention.