Rats (Rattus Norvegicus): Difference between revisions

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    '''Laboratory rats''' or '''lab rats''' are [[strain (biology)|strain]]s of the [[rat]] subspecies ''[[Rattus norvegicus domestica]]'' which are bred and kept for [[scientific research]]. While [[Animal testing on rodents|less commonly used]] for research than [[laboratory mice]], rats have served as an important [[animal model]] for research in [[psychology]] and [[biomedical science]].<ref name="Vandenbergh">{{cite journal |last=Vandenbergh |first=J. G. |title=Use of House Mice in Biomedical Research |journal=[[ILAR Journal]] |date=1 January 2000 |volume=41 |issue=3 |pages=133–135 |doi=10.1093/ilar.41.3.133 |doi-access=free}}</ref>
    [[File:SpragueDawleyRat.jpg|frameless|right]]'''Laboratory rats''' or '''lab rats''' are strains of the rat subspecies ''Rattus norvegicus domestica'' which are bred and kept for scientific research. While less commonly used for research than [[Mice|laboratory mice]], rats have served as an important animal model for research in psychology and biomedical science.<ref name="Vandenbergh">{{cite journal |last=Vandenbergh |first=J. G. |title=Use of House Mice in Biomedical Research |journal=[[ILAR Journal]] |date=1 January 2000 |volume=41 |issue=3 |pages=133–135 |doi=10.1093/ilar.41.3.133 |doi-access=free}}</ref>
     
    == Strains used in Longevity Research ==
     
    {| class="wikitable"
    ! Strain
    ! Characteristics
    ! Typical Lifespan
    ! Prone Diseases
    ! Notable Research Findings
    ! Relevance to Longevity Research
    |-
    | [[Wistar rats|Wistar]]
    | General-purpose strain, albino coat
    | 2-3 years
    | Kidney diseases, tumors
    | Extensively studied in toxicology and pharmacology
    | Commonly used in aging studies due to well-documented lifespan
    |-
    | [[Sprague Dawley rats|Sprague Dawley]]
    | Outbred, albino, large size
    | 2-2.5 years
    | Heart disease, diabetes
    | Often used in cancer research
    | Popular for age-related disease studies
    |-
    | Brown Norway
    | Inbred, brown coat, long lifespan
    | 3-3.5 years
    | Less prone to cancer, but susceptible to respiratory disease
    | Studies have shown exceptional aging characteristics
    | Known for its exceptionally long lifespan, useful for studying aging processes
    |-
    | Fischer 344
    | Inbred, albino, prone to certain age-related diseases
    | 2-2.5 years
    | High incidence of leukemia, immune system decline
    | Common model for immunosenescence studies
    | Frequently used in gerontology for studying age-related pathologies
    |-
    | Long-Evans
    | Outbred, hooded coat, good healthspan
    | 2-3 years
    | Obesity, neurological disorders
    | Used in behavioral and obesity research
    | Utilized in research focusing on the quality of life and health in old age
    |-
    | SHR (Spontaneously Hypertensive Rat)
    | Inbred, used in cardiovascular research
    | 1.5-2 years
    | Cardiovascular diseases, stroke
    | Key model in hypertension and stroke research
    | Valuable for studying the interplay between hypertension and aging
    |}


    == See Also ==
    == See Also ==
    * Wikipedia - [[Wikipedia:Laboratory rat]]
    * {{SeeWikipedia|Laboratory rat}}
    <references />


    == References ==
    == References ==
    <references />
    <references />
    [[Category:Model Organism]]

    Latest revision as of 03:45, 8 December 2023

    SpragueDawleyRat.jpg

    Laboratory rats or lab rats are strains of the rat subspecies Rattus norvegicus domestica which are bred and kept for scientific research. While less commonly used for research than laboratory mice, rats have served as an important animal model for research in psychology and biomedical science.[1]

    Strains used in Longevity Research

    Strain Characteristics Typical Lifespan Prone Diseases Notable Research Findings Relevance to Longevity Research
    Wistar General-purpose strain, albino coat 2-3 years Kidney diseases, tumors Extensively studied in toxicology and pharmacology Commonly used in aging studies due to well-documented lifespan
    Sprague Dawley Outbred, albino, large size 2-2.5 years Heart disease, diabetes Often used in cancer research Popular for age-related disease studies
    Brown Norway Inbred, brown coat, long lifespan 3-3.5 years Less prone to cancer, but susceptible to respiratory disease Studies have shown exceptional aging characteristics Known for its exceptionally long lifespan, useful for studying aging processes
    Fischer 344 Inbred, albino, prone to certain age-related diseases 2-2.5 years High incidence of leukemia, immune system decline Common model for immunosenescence studies Frequently used in gerontology for studying age-related pathologies
    Long-Evans Outbred, hooded coat, good healthspan 2-3 years Obesity, neurological disorders Used in behavioral and obesity research Utilized in research focusing on the quality of life and health in old age
    SHR (Spontaneously Hypertensive Rat) Inbred, used in cardiovascular research 1.5-2 years Cardiovascular diseases, stroke Key model in hypertension and stroke research Valuable for studying the interplay between hypertension and aging

    See Also

    References

    1. ↑ Vandenbergh; "Use of House Mice in Biomedical Research" , https://doi.org/10.1093/ilar.41.3.133
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