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'''Laboratory rats''' or '''lab rats''' are strains of the rat subspecies ''Rattus norvegicus domestica'' which are bred and kept for scientific research. While less commonly used for research than [[Mice|laboratory mice]], rats have served as an important animal model for research in psychology and biomedical science.<ref name="Vandenbergh">{{cite journal |last=Vandenbergh |first=J. G. |title=Use of House Mice in Biomedical Research |journal=[[ILAR Journal]] |date=1 January 2000 |volume=41 |issue=3 |pages=133–135 |doi=10.1093/ilar.41.3.133 |doi-access=free}}</ref> | [[File:SpragueDawleyRat.jpg|frameless|right]]'''Laboratory rats''' or '''lab rats''' are strains of the rat subspecies ''Rattus norvegicus domestica'' which are bred and kept for scientific research. While less commonly used for research than [[Mice|laboratory mice]], rats have served as an important animal model for research in psychology and biomedical science.<ref name="Vandenbergh">{{cite journal |last=Vandenbergh |first=J. G. |title=Use of House Mice in Biomedical Research |journal=[[ILAR Journal]] |date=1 January 2000 |volume=41 |issue=3 |pages=133–135 |doi=10.1093/ilar.41.3.133 |doi-access=free}}</ref> | ||
== Strains used in Longevity Research == | |||
{| class="wikitable" | |||
! Strain | |||
! Characteristics | |||
! Typical Lifespan | |||
! Prone Diseases | |||
! Notable Research Findings | |||
! Relevance to Longevity Research | |||
|- | |||
| [[Wistar rats|Wistar]] | |||
| General-purpose strain, albino coat | |||
| 2-3 years | |||
| Kidney diseases, tumors | |||
| Extensively studied in toxicology and pharmacology | |||
| Commonly used in aging studies due to well-documented lifespan | |||
|- | |||
| [[Sprague Dawley rats|Sprague Dawley]] | |||
| Outbred, albino, large size | |||
| 2-2.5 years | |||
| Heart disease, diabetes | |||
| Often used in cancer research | |||
| Popular for age-related disease studies | |||
|- | |||
| Brown Norway | |||
| Inbred, brown coat, long lifespan | |||
| 3-3.5 years | |||
| Less prone to cancer, but susceptible to respiratory disease | |||
| Studies have shown exceptional aging characteristics | |||
| Known for its exceptionally long lifespan, useful for studying aging processes | |||
|- | |||
| Fischer 344 | |||
| Inbred, albino, prone to certain age-related diseases | |||
| 2-2.5 years | |||
| High incidence of leukemia, immune system decline | |||
| Common model for immunosenescence studies | |||
| Frequently used in gerontology for studying age-related pathologies | |||
|- | |||
| Long-Evans | |||
| Outbred, hooded coat, good healthspan | |||
| 2-3 years | |||
| Obesity, neurological disorders | |||
| Used in behavioral and obesity research | |||
| Utilized in research focusing on the quality of life and health in old age | |||
|- | |||
| SHR (Spontaneously Hypertensive Rat) | |||
| Inbred, used in cardiovascular research | |||
| 1.5-2 years | |||
| Cardiovascular diseases, stroke | |||
| Key model in hypertension and stroke research | |||
| Valuable for studying the interplay between hypertension and aging | |||
|} | |||
== See Also == | == See Also == | ||
* | * {{SeeWikipedia|Laboratory rat}} | ||
== References == | == References == | ||
<references /> | <references /> | ||
[[Category:Model Organism]] | |||