Non-Human Primates

Non-human primates (NHPs) are extensively used in biomedical and behavioral research due to their physiological and genetic similarities to humans. This article explores the use of NHPs in research, focusing on the types of studies, species used, ethical considerations, and regulatory frameworks.

Rationale for Use

• Physiological Similarity to Humans: NHPs are crucial for understanding human biology and medicine, especially in areas like brain function and infectious disease prevention. Their close genetic and physiological similarities to humans, including similar organ systems, immune responses, and brain structures, make them valuable models for human health studies.
• Drug Testing and Vaccine Development: NHPs play a vital role in the safety testing of new drugs and in the development of vaccines. Their similarity to humans in terms of metabolism, pharmacokinetics, and pharmacodynamics is essential for assessing the efficacy and safety of new medical treatments before they are tested in human trials.
• Neurological Research: NHPs are especially important in neurological research due to their complex brain structures that closely resemble those of humans. They are used in studies of neurodegenerative diseases, cognitive function, and brain disorders, providing insights that are not possible with other model organisms.
• Infectious Disease Research: Given their similar immune system responses, NHPs are indispensable in the study of infectious diseases, including HIV/AIDS, Zika virus, and other emerging pathogens. They help in understanding disease progression and in testing the effectiveness of antiviral drugs and vaccines.
• Translational Research: NHPs serve as a critical bridge in translational research, which aims to apply findings from basic science to enhance human health and disease treatments. Their use often leads to direct applications in clinical settings, improving the development of diagnostic methods, treatments, and preventive strategies for various diseases.
• Ethical Implications: While NHPs provide invaluable insights in biomedical research, their use also raises ethical questions due to their cognitive abilities and social structures. This necessitates strict regulations and ethical oversight to ensure their welfare in research settings.

Global Usage and Statistics

More than 100,000 primates are used annually worldwide in biomedical experiments, with over half in the USA, a tenth in Europe, and the rest in Japan and other countries. Despite this, they represent a tiny proportion of total animals used in experiments.

Types of Studies Involving Non-Human Primates

Safety Testing

About 67% of NHPs are used for safety testing of new drugs, substances, and devices, particularly for human medicine and dentistry.

Biological and Medical Research

Approximately 14% of NHPs are used in fundamental biological research, while another 13% are involved in the development of medical and dental products and devices.

Species of Non-Human Primates Used

NHPs include simians (monkeys and apes) and prosimians (like lemurs). The most frequently used species are the long-tailed macaque and the rhesus monkey. In Europe, there is a trend towards using more New World monkeys and fewer prosimians. Great Apes have not been used in the EU since 2005.

Ethical Considerations and Regulation

The use of NHPs in research raises significant ethical concerns. In the EU, animal experimentation is strictly regulated. Additionally, the pharmaceutical industry reports that less than 0.1% of NHPs experience “substantial” suffering in experiments.

Breeding and Use of Captive-Bred Primates

Nearly all primates in experiments are captive-bred. Wild-caught animals are rarely used but are sometimes necessary to prevent inbreeding. Strategies like exchanging wild-caught males between facilities are considered to maintain genetic diversity without relying heavily on wild captures.

Conclusion

NHPs remain integral to scientific research, but their use is surrounded by ethical debates, regulatory oversight, and a push towards finding alternative methods. The balance between scientific advancement and humane treatment of these animals continues to be a key focus in the scientific community.

See Also

• Model Organisms