2,851
edits
Caloric Restriction: Difference between revisions
→Mechanism
(→Todo) |
|||
| Line 21: | Line 21: | ||
The NIA study on rhesus monkeys found no lifespan extension.{{pmid|22932268}} In a long-term study conducted at the ''Wisconsin National Primate Research Center'' over a period of 20 years on rhesus monkeys, a significantly better health status and a significantly increased lifespan were observed in the group of animals that received a reduced food supply during this period. In this group, 80% of the animals were still alive, compared to only 50% in the normally fed control group. Furthermore, in the animals with calorie restriction, a significantly delayed onset of age-associated diseases such as diabetes, cancer, and brain atrophy, as well as cardiovascular incidents, was observed. The authors of the study conclude that calorie restriction delays the aging process in this primate species.{{pmid|19590001}} | The NIA study on rhesus monkeys found no lifespan extension.{{pmid|22932268}} In a long-term study conducted at the ''Wisconsin National Primate Research Center'' over a period of 20 years on rhesus monkeys, a significantly better health status and a significantly increased lifespan were observed in the group of animals that received a reduced food supply during this period. In this group, 80% of the animals were still alive, compared to only 50% in the normally fed control group. Furthermore, in the animals with calorie restriction, a significantly delayed onset of age-associated diseases such as diabetes, cancer, and brain atrophy, as well as cardiovascular incidents, was observed. The authors of the study conclude that calorie restriction delays the aging process in this primate species.{{pmid|19590001}} | ||
==Effects in Humans== | |||
The hormonal and metabolic effects of calorie restriction observed in experimental animals, such as lower [[body temperature]], reduced metabolic rate, and decreased [[oxidative stress]], have also been demonstrated in humans.{{pmid|18729811}}{{pmid|16595757}} Additionally, lower serum levels of basal [[insulin]] ("fasting insulin"), [[Fibrosis|profibrotic]] [[Protein|proteins]], various [[Growth factor (Protein)|growth factors]] - such as [[Platelet Derived Growth Factor|PDGF]] and [[Transforming growth factor|TGF-α]] - as well as [[Cytokine|cytokines]] like [[Tumor Necrosis Factor]]-α have been detected.{{pmid|15096581}}{{pmid|17389710}}{{pmid|17093155}}{{pmid|16732018}}{{pmid|16412867}} It is also established that long-term calorie restriction is an effective prevention against [[Type II Diabetes]], [[Arterial Hypertension|high blood pressure]], and [[Atherosclerosis]], which together are the main causes of [[Morbidity]], [[Disability (Social Law)|disabilities]], and [[Mortality]] in humans.{{pmid|19262201}} | |||
== Mechanism == | == Mechanism == | ||