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Pharmacokinetics: Difference between revisions
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{| class="wikitable" style="margin-left: auto; margin-right: auto; border: none;" | {| class="wikitable" style="margin-left: auto; margin-right: auto; border: none;" | ||
|+ | |+<big><strong>Pharmacokinetic metrics</strong></big> | ||
! style="width:6.5em;" | Characteristic | ! style="width:6.5em;" | Characteristic | ||
! Description | ! Description | ||
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|- | |- | ||
| [[Dose (biochemistry)|Dose]] || Amount of drug administered. || <math>D</math> | | [[Dose (biochemistry)|Dose]] || Amount of drug administered. || <math>D</math> | ||
| <math>\mathrm{mol}</math> || | | <math>\mathrm{mol}</math> || N/A (Design parameter) | ||
| 500 mmol | | 500 mmol | ||
|- | |- | ||
| [[Dosing interval]] || Time interval between drug dose administrations. || <math>\tau</math> | | [[Dosing interval]] || Time interval between drug dose administrations. || <math>\tau</math> | ||
| <math>\mathrm{h}</math> || | | <math>\mathrm{h}</math> || N/A (Design parameter) | ||
| 24 h | | 24 h | ||
|- | |- | ||
| [[Cmax | | [[Maximum Serum Concentration (Cmax)|{{nobr|Maximum serum concentration}}]] || The peak plasma concentration of a drug after administration. || <math>C_\text{max}</math> | ||
| <math>\mathrm{mmol/L}</math> || | | <math>\mathrm{mmol/L}</math> || N/A (Direct measurement) | ||
| 60.9 mmol/L | | 60.9 mmol/L | ||
|- | |- | ||
| [[ | | [[Tmax|{{nobr|Minimum time for C<sub>max</sub>}}]] || Minimum time taken to reach C<sub>max</sub>. || <math>t_\text{max}</math> | ||
| <math>\mathrm{h}</math> || | | <math>\mathrm{h}</math> || N/A (Direct measurement) | ||
| 3.9 h | | 3.9 h | ||
|- | |- | ||
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| 0.693 h<sup>−1</sup> | | 0.693 h<sup>−1</sup> | ||
|- | |- | ||
| [[ | | [[Elimination Half-Life|Elimination half-{{zero width joiner}}life]] || The time required for the concentration of the drug to reach half of its original value. | ||
| <math>t_{\frac{1}{2}b}</math> | | <math>t_{\frac{1}{2}b}</math> | ||
| <math>\mathrm{h}</math> || <math>\frac{\ln(2)}{k_\text{e}}</math> | | <math>\mathrm{h}</math> || <math>\frac{\ln(2)}{k_\text{e}}</math> | ||
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| 50 mmol/h | | 50 mmol/h | ||
|- | |- | ||
| rowspan=2 | [[Area | | rowspan=2 | [[Area Under the Curve (AUC)|Area under the curve]] | ||
| rowspan=2 | The [[integral]] of the concentration-time curve (after a single dose or in steady state). | | rowspan=2 | The [[integral]] of the concentration-time curve (after a single dose or in steady state). | ||
| <math>AUC_{0 - \infty}</math> | | <math>AUC_{0 - \infty}</math> | ||
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<math>C_{\text{av}, \text{ss}}=\frac{AUC_{\tau,\text{ss}}}{\tau}</math> | <math>C_{\text{av}, \text{ss}}=\frac{AUC_{\tau,\text{ss}}}{\tau}</math> | ||
| 41.8% | | 41.8% | ||
|} | |} | ||
== See Also == | |||
==See | |||
* {{ | * {{SeeWikipedia|Pharmacokinetics}} | ||
==References== | |||
== References == | |||
[[Category: | <references /> | ||
[[Category:Pharmacokinetics|!Pharmacokinetics]] | |||