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Nicotinamide Mononucleotide (NMN): Difference between revisions
Nicotinamide Mononucleotide (NMN) (view source)
Revision as of 21:55, 15 December 2023
, 15 December 2023→Stability
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Additionally, it's noteworthy that two MIB-626 trials utilized a twice per day administration regimen. This dosing schedule is significant because it could potentially offer more consistent NAD+ level support throughout the day, although the specific implications of this frequency in relation to circadian rhythms and overall efficacy remain an area for further research.{{pmid|35182418}}{{pmid|36740954}} | Additionally, it's noteworthy that two MIB-626 trials utilized a twice per day administration regimen. This dosing schedule is significant because it could potentially offer more consistent NAD+ level support throughout the day, although the specific implications of this frequency in relation to circadian rhythms and overall efficacy remain an area for further research.{{pmid|35182418}}{{pmid|36740954}} | ||
=== Stability === | === Stability and Storage === | ||
NMN powders are thought to degrade into NAD+ when left at room temperature. However, this may be true for pure NMN supplements, some supplements use NMN in a stabilized form. This form has been shown to be more stable thus resulting in less breakdown at room temperature.<ref>https://healthnews.com/longevity/longevity-supplements/proper-storage-of-nicotinamide-mononucleotide-powder/</ref> | |||
Humidity or water can have negative effects on NMN and result in the degradation of NMN into NAD+. This fact is not disputed and thus NMN powder should be stored in a dry place in a resealable container. | |||
In addition, scientists have tested NMN powders and found that these do not need to be kept in the refrigerator or freezer. The purity at 1 year when stored in a plastic bottle at room temperature was found to be 99.8%. | |||
However, it is advised if storing for the long-term (> 3 months), NMN supplements should be kept in the refrigerator to ensure its stability. | |||
Overall, NMN powders are stable when '''stored at room temperature,''' especially when provided in a stabilized form. However, they '''need to be kept away from high-humidity''' environments as water can speed up the degradation of NMN. So if you plan to consume the powder immediately (< 1–2 months) you do not need to '''store it in the refrigerator''' but if stored for> 3 months it is best to store it in the refrigerator. | |||
'''Always consult the manufacturer''' of you specific NMN supplements to obtain proper storage instructions for your product. If concerned, storing the NMN in the refrigerator does not have negative effects on the NMN and thus can be done. | |||
NMN supplements, especially those in a stabilized form, can be stored at room temperature without a significant reduction in their purity. However, always consult the specific manufacture to determine the recommended storage criteria for your NMN supplements. | |||
NMN appears to be stable in water; in one study 93%–99% of NMN was maintained intact in drinking water at room temperature for 7–10 days.{{pmid|21901281}} | NMN appears to be stable in water; in one study 93%–99% of NMN was maintained intact in drinking water at room temperature for 7–10 days.{{pmid|21901281}} | ||