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Nicotinamide Mononucleotide (NMN): Difference between revisions
Nicotinamide Mononucleotide (NMN) (view source)
Revision as of 00:03, 19 December 2023
, 19 December 2023→Synergistic Supplements in Conjunction with NMN
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While Nicotinamide Mononucleotide (NMN) itself is a promising compound in the realm of anti-aging and cellular health, its potential can be further enhanced when used in conjunction with other supplements. This section explores various nutraceuticals that may have synergistic effects when taken alongside NMN, potentially amplifying its benefits.{{pmid|36678315}} | While Nicotinamide Mononucleotide (NMN) itself is a promising compound in the realm of anti-aging and cellular health, its potential can be further enhanced when used in conjunction with other supplements. This section explores various nutraceuticals that may have synergistic effects when taken alongside NMN, potentially amplifying its benefits.{{pmid|36678315}} | ||
=== | ===Stilbenes: Resveratrol and Pterostilbene=== | ||
Stilbenes, particularly resveratrol and pterostilbene, are non-flavonoid phenolic compounds extensively studied for their anti-inflammatory, antioxidant properties, and their role in combating age-related disorders like diabetes and cancer{{pmid|23448440}}{{ | Stilbenes, particularly resveratrol and pterostilbene, are non-flavonoid phenolic compounds extensively studied for their anti-inflammatory, antioxidant properties, and their role in combating age-related disorders like diabetes and cancer{{pmid|23448440}}<ref>{{doi|10.7324/JAPS.2019.90717|Chan EWC, Wong CW, Tan YH, Foo JPY, Wong SK, Chan HT. Resveratrol and pterostilbene: A comparative overview of their chemistry, biosynthesis, plant sources and pharmacological properties. J Appl Pharm Sci, 2019; 9(07):124–129.}}</ref>. They are found naturally in grapes and berries, and studies have established their safety and bioavailability, with doses of resveratrol up to 5 grams and pterostilbene to 250 mg being well-tolerated{{pmid|23431291}}{{pmid|30513922}}. | ||
Despite their potential, resveratrol and pterostilbene have shown lifespan extension only in certain preclinical models, with the results being context-dependent and subject to debate{{pmid|29210129}}. Pterostilbene is particularly notable for its higher bioavailability (80%) compared to resveratrol (20%), and its efficacy in upregulating antioxidant enzymes like SOD and GR{{pmid|23691264}}. This difference in bioavailability is critical in modulating the SIRT1 pathway, with co-administration of the two potentially maximizing their collective benefits{{pmid|18826454}}. | Despite their potential, resveratrol and pterostilbene have shown lifespan extension only in certain preclinical models, with the results being context-dependent and subject to debate{{pmid|29210129}}. Pterostilbene is particularly notable for its higher bioavailability (80%) compared to resveratrol (20%), and its efficacy in upregulating antioxidant enzymes like SOD and GR{{pmid|23691264}}. This difference in bioavailability is critical in modulating the SIRT1 pathway, with co-administration of the two potentially maximizing their collective benefits{{pmid|18826454}}. | ||