Nicotinamide Mononucleotide (NMN): Difference between revisions

Nicotinamide Mononucleotide (NMN) (view source)

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 Resveratrol's role in skin health, through its anti-angiogenic and wound-healing properties, is well-documented{{pmid|23567244}}{{pmid|33949795}}, while pterostilbene effectively mitigates inflammatory responses in various contexts{{pmid|24186934}}{{pmid|24705157}}{{pmid|15832402}}{{pmid|34679686}}.
-The relationship between resveratrol and the SIRT1 pathway is a key focus in experimental models, especially in the context of dosage and supplementation{{doi|10.1017/S0029665113002164}}{{pmid|21613817}}. Although resveratrol has shown numerous health benefits, its direct activation of SIRT1 remains a subject of debate. Nonetheless, its indirect involvement in SIRT1 activation and its mimicry of caloric restriction effects suggest its potential as a metabolic modulator related to aging{{pmid|21569839}}{{pmid|27552971}}.
+The relationship between resveratrol and the SIRT1 pathway is a key focus in experimental models, especially in the context of dosage and supplementation{{doi|10.1017/S0029665113002164|Escolme SM, Wakeling LA, Alatawi F, Valentine R, Ford D. Does resveratrol act independently of SIRT1 to affect genes relevant to ageing? Proceedings of the Nutrition Society. 2013;72(OCE4):E191.}}{{pmid|21613817}}. Although resveratrol has shown numerous health benefits, its direct activation of SIRT1 remains a subject of debate. Nonetheless, its indirect involvement in SIRT1 activation and its mimicry of caloric restriction effects suggest its potential as a metabolic modulator related to aging{{pmid|21569839}}{{pmid|27552971}}.
-Resveratrol and pterostilbene's potential in conjunction with NMN supplementation is particularly promising. Their combined use can lead to increased NAD+ levels in the heart and skeletal muscle, more so than NMN alone{{pmid|35844164}}. Resveratrol's ability to activate NMNAT1, thus increasing NAD+ levels and providing a substrate for SIRT1 activation, underscores the potential of these compounds in a targeted approach to delay or reverse aging signs{{doi|10.1038/npre.2010.4421.1}}. Their co-administration with NR has also shown a dose-dependent increase in NAD+ levels in acute kidney injury patients, further supporting their combined use in age-related therapies{{pmid|32791973}}{{pmid|29184669}}.
+Resveratrol and pterostilbene's potential in conjunction with NMN supplementation is particularly promising. Their combined use can lead to increased NAD+ levels in the heart and skeletal muscle, more so than NMN alone{{pmid|35844164}}. Resveratrol's ability to activate NMNAT1, thus increasing NAD+ levels and providing a substrate for SIRT1 activation, underscores the potential of these compounds in a targeted approach to delay or reverse aging signs{{doi|10.1038/npre.2010.4421.1|Grant, R. Resveratrol Increases Intracellular NAD+ Levels Through Up regulation of The NAD+ Synthetic Enzyme Nicotinamide Mononucleotide Adenylyltransferase. Nat Prec (2010).}}. Their co-administration with NR has also shown a dose-dependent increase in NAD+ levels in acute kidney injury patients, further supporting their combined use in age-related therapies{{pmid|32791973}}{{pmid|29184669}}.
 In summary, resveratrol and pterostilbene, especially when used in combination with NMN, represent a strategic orthomolecular approach to enhancing longevity and managing age-related diseases.