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Nicotinamide Mononucleotide (NMN): Difference between revisions
Nicotinamide Mononucleotide (NMN) (view source)
Revision as of 00:05, 20 December 2023
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*'''Interplay with NAD+''': The relationship between aKG and NAD+, a vital coenzyme for cellular health and aging, remains under-researched. Future studies should explore this interaction to enhance our understanding of how aKG can be utilized in longevity therapies. | *'''Interplay with NAD+''': The relationship between aKG and NAD+, a vital coenzyme for cellular health and aging, remains under-researched. Future studies should explore this interaction to enhance our understanding of how aKG can be utilized in longevity therapies. | ||
The potential of aKG in anti-aging strategies is promising, but more research is necessary to fully understand its interactions, particularly with NAD+. | The potential of aKG in anti-aging strategies is promising, but more research is necessary to fully understand its interactions, particularly with NAD+. | ||
===Epigallocatechin Gallate=== | |||
The polyphenol epigallocatechin gallate (EGCG; Figure 2), predominantly found in green tea, is renowned for its neuroprotective, antioxidant, and anti-inflammatory properties. Current research is investigating its role in alleviating a variety of diseases{{pmid|35327563}}. EGCG's interaction with aging and longevity pathways is particularly noteworthy. | |||
*'''Lifespan Extension''': EGCG has been shown to increase lifespan in response to oxidative stress, as evidenced by studies in rats demonstrating enhanced longevity under such conditions{{pmid|23834676}}. | |||
*'''SIRT1 Modulation''': The effect of EGCG on SIRT1, a crucial protein in aging and metabolism, appears to vary depending on the context. Some studies have observed an upregulation of SIRT1 following EGCG administration{{pmid|33371812}}, while others have reported a downregulation, especially in cancer cells{{pmid|23881751}}{{pmid|35548580}}. This suggests that EGCG's impact on SIRT1 may differ based on specific biological factors and the need for upregulation of longevity pathways in response to oxidative stress. | |||
*'''NAD+/NADH Ratio Effects''': The influence of EGCG on the NAD+/NADH ratio, vital for cellular metabolism and aging, requires further investigation. Understanding how EGCG affects this ratio is essential for comprehending its potential as an anti-aging agent and its role in cellular health maintenance. | |||
The diverse effects of EGCG on SIRT1 and the NAD+/NADH ratio underline the importance of more detailed research to clarify its mechanisms of action, particularly regarding longevity and age-related diseases. | |||
==Clinical Trials== | ==Clinical Trials== | ||
Starting in 2020, with the assessment of the safety of a single dose administration of NMN, there have been around 10 randomized controlled trials (RCTs) exploring the compound's effects in various contexts. The trials have varied in duration, with the longest running for 12 weeks. In terms of dosage, they have explored a range of quantities, with the highest being 1,250 mg of NMN per day and 2,000 mg (2 g) of MIB-626, a specific formulation of NMN, per day. The following table provides a comprehensive overview of these trials, detailing their design, participant demographics, dosages, and key findings: | Starting in 2020, with the assessment of the safety of a single dose administration of NMN, there have been around 10 randomized controlled trials (RCTs) exploring the compound's effects in various contexts. The trials have varied in duration, with the longest running for 12 weeks. In terms of dosage, they have explored a range of quantities, with the highest being 1,250 mg of NMN per day and 2,000 mg (2 g) of MIB-626, a specific formulation of NMN, per day. The following table provides a comprehensive overview of these trials, detailing their design, participant demographics, dosages, and key findings: | ||