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Caloric Restriction: Difference between revisions
→Potential Calorie Restriction Mimetics
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According to Ingram, various substances are considered as mimetics of calorie restriction in the human body:{{pmid|16626389}} | According to Ingram, various substances are considered as mimetics of calorie restriction in the human body:{{pmid|16626389}} | ||
* [[2-Deoxy-D-glucose|2-Deoxy-<small>D</small>-glucose]] can initiate [[Ketogenesis|ketogenesis]]{{pmid|21747957}}, makes rats gain slightly less body weight than control animals and leads to a significant reduction in body temperature and fasting serum insulin levels, thereby simulating certain effects of calorie restriction.{{doi|10.1089/rej.1.1998.1.327}} | * [[2-Deoxy-D-glucose|2-Deoxy-<small>D</small>-glucose]] can initiate [[Ketogenesis|ketogenesis]]{{pmid|21747957}}, makes rats gain slightly less body weight than control animals and leads to a significant reduction in body temperature and fasting serum insulin levels, thereby simulating certain effects of calorie restriction.{{doi|10.1089/rej.1.1998.1.327|MARK A. LANE, DONALD K. INGRAM, and GEORGE S. ROTH. | ||
2-Deoxy-D-Glucose Feeding in Rats Mimics Physiologic Effects of Calorie Restriction. | |||
Journal of Anti-Aging Medicine.Jan 1998.327-337.}} | |||
* [[Metformin]], an orally administered [[antidiabetic]], reduces cancer incidence in rats and slows the progression of the disease. It also reduces the occurrence of cardiovascular diseases and extends lifespan.{{pmid|20304770}} | * [[Metformin]], an orally administered [[antidiabetic]], reduces cancer incidence in rats and slows the progression of the disease. It also reduces the occurrence of cardiovascular diseases and extends lifespan.{{pmid|20304770}} | ||
* [[Glipizide]], like Metformin, is an orally administered [[antidiabetic]] that helps control blood sugar levels. It works by partially blocking the potassium channels of the beta cells of the [[Islets of Langerhans]].{{pmid|6369967}} | * [[Glipizide]], like Metformin, is an orally administered [[antidiabetic]] that helps control blood sugar levels. It works by partially blocking the potassium channels of the beta cells of the [[Islets of Langerhans]].{{pmid|6369967}} | ||