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[[File:The Nine Hallmarks of Aging.jpg|thumb|The original nine hallmarks of aging as proposed by López-Otín and colleagues in 2013{{pmid|23746838}}]] | |||
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. The '''hallmarks of aging''' are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death. They were first listed in a landmark paper in 2013{{pmid|23746838}} to conceptualize the essence of biological aging and its underlying mechanisms. | Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. The '''hallmarks of aging''' are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death. They were first listed in a landmark paper in 2013{{pmid|23746838}} to conceptualize the essence of biological aging and its underlying mechanisms. | ||