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Spermidine: Difference between revisions
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==Spermidine and Longevity== | ==Spermidine and Longevity== | ||
Research has identified a significant correlation between the exogenous supplementation of spermidine and increased lifespan in several model organisms such as yeast, worms, flies, and mice.<ref>https://genomics.senescence.info/drugs/browse.php?search_term=spermidine</ref> The longevity-promoting properties of spermidine are primarily attributed to its role in inducing autophagy.{{#pmid:27841876|pmid27841876}} | Research has identified a significant correlation between the exogenous supplementation of spermidine and increased lifespan in several model organisms such as yeast, worms, flies, and mice.<ref>https://genomics.senescence.info/drugs/browse.php?search_term=spermidine</ref> The longevity-promoting properties of spermidine are primarily attributed to its role in inducing autophagy.{{#pmid:27841876|pmid27841876}} | ||
The [[Interventions Testing Program (ITP)]] gave mice spermidine for 6 month. However, no increase in spermidine or spermine levels was observed in the blood, liver, or other tissues. The lack of change in spermidine levels led to the decision not to proceed with further lifespan testing in mice.<ref>[[2022-04-12 - Dr. Richard Miller - Longevity Supplements - Interventions Testing Program Results]]</ref> | |||
=== Autophagy === | === Autophagy === | ||
Autophagy is a cellular process involved in the degradation and recycling of obsolete or dysfunctional cellular components. This mechanism is vital for maintaining cellular homeostasis and plays a central role in cell and tissue health. Spermidine's ability to enhance autophagy is of particular interest in the context of aging, as the decline in autophagy has been associated with several age-related pathologies, including neurodegeneration, cardiovascular disease, and cancer. | [[Autophagy]] is a cellular process involved in the degradation and recycling of obsolete or dysfunctional cellular components. This mechanism is vital for maintaining cellular homeostasis and plays a central role in cell and tissue health. Spermidine's ability to enhance autophagy is of particular interest in the context of aging, as the decline in autophagy has been associated with several age-related pathologies, including neurodegeneration, cardiovascular disease, and cancer. | ||
Spermidine promotes autophagy through the inhibition of a specific enzyme called acetyltransferase EP300. This inhibition leads to a series of cellular events that eventually increase the autophagic processes within the cells. Essentially, spermidine helps in "cleaning up" the cell interiors, which is crucial for cellular maintenance and health, especially as the body ages{{#pmid:25526088|pmid25526088}}. | Spermidine promotes autophagy through the inhibition of a specific enzyme called acetyltransferase EP300. This inhibition leads to a series of cellular events that eventually increase the autophagic processes within the cells. Essentially, spermidine helps in "cleaning up" the cell interiors, which is crucial for cellular maintenance and health, especially as the body ages{{#pmid:25526088|pmid25526088}}. | ||
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== See Also == | == See Also == | ||
* | * {{SeeWikipedia|Spermidine|}} | ||
== ToDo== | |||
* https://phys.org/news/2024-01-deciphering-molecular-mysteries-insights-metabolites.html | |||
==References== | ==References== | ||