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Resveratrol: Difference between revisions
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Resveratrol is a type of natural phenol, and a phytoalexin produced by several plants in response to injury or when the plant is under attack by pathogens such as bacteria or fungi. Its molecular formula is C₁₄H₁₂O₃, and it belongs to a class of compounds known as stilbenes. | Resveratrol is a type of natural phenol, and a phytoalexin produced by several plants in response to injury or when the plant is under attack by pathogens such as bacteria or fungi. Its molecular formula is C₁₄H₁₂O₃, and it belongs to a class of compounds known as stilbenes. | ||
The potential of resveratrol to impact longevity stems from its ability to modulate several biological pathways that are implicated in the aging process. It is renowned for its antioxidant and anti-inflammatory properties, which can mitigate the damaging effects of oxidative stress and inflammation, two key contributors to aging and age-related diseases. Additionally, resveratrol is known to activate sirtuins, a family of proteins that play a crucial role in cellular health and longevity. | The potential of resveratrol to impact longevity stems from its ability to modulate several biological pathways that are implicated in the aging process. It is renowned for its [[Antioxidant|antioxidant]] and anti-inflammatory properties, which can mitigate the damaging effects of oxidative stress and inflammation, two key contributors to aging and age-related diseases. Additionally, resveratrol is known to activate sirtuins, a family of proteins that play a crucial role in cellular health and longevity. | ||
== Historical Context == | == Historical Context == | ||
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=== Initial Studies and Findings === | === Initial Studies and Findings === | ||
The early studies primarily focused on the antioxidant properties of resveratrol. Researchers found that it had the ability to scavenge free radicals and reduce oxidative stress, which are key contributors to aging and age-related diseases. These initial findings sparked interest in resveratrol as a potential anti-aging compound. | The early studies primarily focused on the [[Antioxidant|antioxidant]] properties of resveratrol. Researchers found that it had the ability to scavenge free radicals and reduce oxidative stress, which are key contributors to aging and age-related diseases. These initial findings sparked interest in resveratrol as a potential anti-aging compound. | ||
=== Evolution of Resveratrol Research === | === Evolution of Resveratrol Research === | ||
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=== Antioxidant Properties === | === Antioxidant Properties === | ||
Resveratrol exhibits powerful [[antioxidant]] properties, which play a crucial role in combating oxidative stress, a key contributor to aging and age-related diseases. It neutralizes free radicals and reduces oxidative damage to cells, potentially prolonging cellular health and vitality. | Resveratrol exhibits powerful [[Antioxidant|antioxidant]] properties, which play a crucial role in combating [[Oxidative Stress|oxidative stress]], a key contributor to aging and age-related diseases. It neutralizes free radicals and reduces oxidative damage to cells, potentially prolonging cellular health and vitality. | ||
=== Anti-Inflammatory Effects === | === Anti-Inflammatory Effects === | ||
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*'''Trans-resveratrol''' is the most abundant and biologically active form of resveratrol in plants. It is the form that has been most studied in scientific research and is thought to be responsible for the majority of the health benefits associated with resveratrol. | *'''Trans-resveratrol''' is the most abundant and biologically active form of resveratrol in plants. It is the form that has been most studied in scientific research and is thought to be responsible for the majority of the health benefits associated with resveratrol. | ||
*'''Cis-resveratrol''' is less abundant in nature and less biologically active than trans-resveratrol. However, it has still been shown to have some health benefits, such as antioxidant and anti-inflammatory effects. | *'''Cis-resveratrol''' is less abundant in nature and less biologically active than trans-resveratrol. However, it has still been shown to have some health benefits, such as [[Antioxidant|antioxidant]] and anti-inflammatory effects. | ||
In addition to cis- and trans-resveratrol, there are also a number of other forms of resveratrol, including: | In addition to cis- and trans-resveratrol, there are also a number of other forms of resveratrol, including: | ||
*'''Piceatannol:''' Piceatannol is a metabolite of resveratrol that is found in red grape skins and Japanese knotweed. It has been shown to have some similar health benefits to trans-resveratrol, such as antioxidant and anti-cancer effects. | *'''Piceatannol:''' Piceatannol is a metabolite of resveratrol that is found in red grape skins and Japanese knotweed. It has been shown to have some similar health benefits to trans-resveratrol, such as [[Antioxidant|antioxidant]] and anti-cancer effects. | ||
*'''Resveratrol glucosides:''' Resveratrol glucosides are conjugated forms of resveratrol that are linked to glucose molecules. These forms of resveratrol are less bioavailable than trans-resveratrol, but they may be more stable and easier to store. | *'''Resveratrol glucosides:''' Resveratrol glucosides are conjugated forms of resveratrol that are linked to glucose molecules. These forms of resveratrol are less bioavailable than trans-resveratrol, but they may be more stable and easier to store. | ||
*'''Resveratrol dimers and oligomers:''' Resveratrol dimers and oligomers are formed when two or more molecules of resveratrol link together. These forms of resveratrol have been shown to have some unique biological activities, such as anti-cancer and anti-inflammatory effects. | *'''Resveratrol dimers and oligomers:''' Resveratrol dimers and oligomers are formed when two or more molecules of resveratrol link together. These forms of resveratrol have been shown to have some unique biological activities, such as anti-cancer and anti-inflammatory effects. | ||