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Quercetin: Difference between revisions
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'''Quercetin''' is a naturally occurring flavonoid found in a wide variety of fruits, vegetables, and grains. It is one of the most abundant antioxidants in the human diet and plays a significant role in helping to protect cells from damage caused by free radicals. | [[File:Quercetin.svg|right|frameless]] | ||
'''Quercetin''' is a naturally occurring flavonoid found in a wide variety of fruits, vegetables, and grains. It is one of the most abundant [[Antioxidant|antioxidants]] in the human diet and plays a significant role in helping to protect cells from damage caused by free radicals. | |||
Quercetin belongs to the class of polyphenolic compounds known as flavonoids, recognized for their diverse biological activities. It is a pigment that is responsible, in part, for the colors of many fruits, vegetables, and flowers. Structurally, quercetin is characterized by the presence of a 15-carbon skeleton consisting of two phenyl rings and a heterocyclic ring. | Quercetin belongs to the class of polyphenolic compounds known as flavonoids, recognized for their diverse biological activities. It is a pigment that is responsible, in part, for the colors of many fruits, vegetables, and flowers. Structurally, quercetin is characterized by the presence of a 15-carbon skeleton consisting of two phenyl rings and a heterocyclic ring. | ||
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The term "quercetin" is derived from ''quercetum'' (oak forest), reflecting its presence in oak trees. It was first isolated in 1857 by the Austrian chemist Heinrich Hlasiwetz. Since its discovery, quercetin has been the subject of extensive research, with numerous studies exploring its potential health benefits, primarily due to its antioxidant, anti-inflammatory, antiviral, and anticancer properties. | The term "quercetin" is derived from ''quercetum'' (oak forest), reflecting its presence in oak trees. It was first isolated in 1857 by the Austrian chemist Heinrich Hlasiwetz. Since its discovery, quercetin has been the subject of extensive research, with numerous studies exploring its potential health benefits, primarily due to its antioxidant, anti-inflammatory, antiviral, and anticancer properties. | ||
In plants, quercetin serves as a protective substance, defending against microbial infections and environmental stress. For humans, it’s predominantly obtained through the consumption of foods such as onions, apples, berries, and teas. Its biological roles in human health are vast, with studies suggesting benefits ranging from anti-aging and anti-inflammatory effects to potential protective roles against various diseases. | In plants, quercetin serves as a protective substance, defending against microbial infections and environmental stress. This feature positions quercetin as a [[Xenohormetic Compound|xenohormetic compound]], implying that it not only protects the plants producing it but also potentially offers health benefits to humans who consume these plants. For humans, it’s predominantly obtained through the consumption of foods such as onions, apples, berries, and teas. Its biological roles in human health are vast, with studies suggesting benefits ranging from anti-aging and anti-inflammatory effects to potential protective roles against various diseases. | ||
== Natural Occurrence and Derivatives== | == Natural Occurrence and Derivatives== | ||
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In a study sponsored by Natural Factors, the bioavailability of Standard Quercetin, Quercetin Phytosome and Quercetin LipoMicel was evaluated. The results indicated that Quercetin LipoMicel had a relative bioavailability to Standard Quercetin of 8.5, while Quercetin Phytosome exhibited a slightly higher value of 8.9. Notably, LipoMicel maintained more consistent levels of quercetin in the system over a 24-hour period. <ref name=":1">https://jnhpresearch.com/index.php/jnhpr/article/view/17/24</ref> | In a study sponsored by Natural Factors, the bioavailability of Standard Quercetin, Quercetin Phytosome and Quercetin LipoMicel was evaluated. The results indicated that Quercetin LipoMicel had a relative bioavailability to Standard Quercetin of 8.5, while Quercetin Phytosome exhibited a slightly higher value of 8.9. Notably, LipoMicel maintained more consistent levels of quercetin in the system over a 24-hour period. <ref name=":1">https://jnhpresearch.com/index.php/jnhpr/article/view/17/24</ref> | ||
In a second study, the blood concentrations of quercetin in healthy participants after the administration of standard quercetin and LipeMice quercetin was evaluated with over 72 hours and 4 doses in total. In contrast to other studies, the administration was given after 10 hours of fasting and continued fasting for 4 hours afterward to reduce potential interactions with food components like fiber and fat. Within the first 24 hours, LipeMice (500mg) had a significantly 7-fold increased blood concentrations of quercetin compared to standard quercetin (500 mg). LipeMice administered at a double dose (1000 mg) achieved 15-fold higher absorption, LipeMice tested at half a dose of standard quercetin increased concentration by approx. 3-fold. Quercetin blood concentrations were attained over 72 hours. | In a second study, the blood concentrations of quercetin in healthy participants after the administration of standard quercetin and LipeMice quercetin was evaluated with over 72 hours and 4 doses in total. In contrast to other studies, the administration was given after 10 hours of fasting and continued fasting for 4 hours afterward to reduce potential interactions with food components like fiber and fat. Within the first 24 hours, LipeMice (500mg) had a significantly 7-fold increased blood concentrations of quercetin compared to standard quercetin (500 mg). LipeMice administered at a double dose (1000 mg) achieved 15-fold higher absorption, LipeMice tested at half a dose of standard quercetin increased concentration by approx. 3-fold. Quercetin blood concentrations were attained over 72 hours. {{#pmid:37600550|pmid37600550}} | ||
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! colspan="3" |Study 1 <ref name=":1" /> | ! colspan="3" |Study 1 <ref name=":1" /> | ||
! colspan="4" |Study 2 (with fasting) | ! colspan="4" |Study 2 (with fasting) {{#pmid:37600550|pmid37600550}} | ||
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: Quercetin’s potent anti-inflammatory properties have led to its investigation for use in chronic inflammatory conditions such as arthritis and cardiovascular diseases. It modulates inflammatory pathways by inhibiting the release of pro-inflammatory cytokines and reducing the activation of inflammatory cells. | : Quercetin’s potent anti-inflammatory properties have led to its investigation for use in chronic inflammatory conditions such as arthritis and cardiovascular diseases. It modulates inflammatory pathways by inhibiting the release of pro-inflammatory cytokines and reducing the activation of inflammatory cells. | ||
; Antioxidant Properties | ; [[Antioxidant]] Properties | ||
: The antioxidant activity of quercetin is attributed to its ability to neutralize free radicals and reduce oxidative stress, potentially mitigating aging-related cellular damage and dysfunction. Its antioxidant properties are linked to a reduction in the risk of chronic conditions such as cancer and neurodegenerative diseases. | : The antioxidant activity of quercetin is attributed to its ability to neutralize free radicals and reduce oxidative stress, potentially mitigating aging-related cellular damage and dysfunction. Its antioxidant properties are linked to a reduction in the risk of chronic conditions such as cancer and neurodegenerative diseases. | ||
; Impact on Cellular Senescence | ; Impact on [[Cellular Senescence]] | ||
: Research has indicated that quercetin may delay cellular senescence by modulating senescence-associated signaling pathways and reducing the accumulation of senescent cells, potentially impacting aging processes and age-related diseases. | : Research has indicated that quercetin may delay cellular senescence by modulating senescence-associated signaling pathways and reducing the accumulation of senescent cells, potentially impacting aging processes and age-related diseases. | ||
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===Administration Forms and Bioavailability Enhancement=== | ===Administration Forms and Bioavailability Enhancement=== | ||
Quercetin is available in various forms, including tablets, capsules, and powders. To enhance its bioavailability, it is often formulated with bioflavonoids or bromelain, or encapsulated in liposomes or phytosomes. Different formulations may affect the absorption and efficacy of quercetin, and choosing the right form is crucial for optimal results. | Quercetin is available in various forms, including tablets, capsules, and powders. To enhance its bioavailability, it is often formulated with bioflavonoids or bromelain, or encapsulated in [[Liposomes|liposomes]] or phytosomes. Different formulations may affect the absorption and efficacy of quercetin, and choosing the right form is crucial for optimal results. | ||
==Safety and Side Effects== | ==Safety and Side Effects== | ||
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==Conclusions and Future Directions== | ==Conclusions and Future Directions== | ||
'''Quercetin''' has garnered substantial attention in the realm of longevity and health due to its multifaceted biological activities, including antioxidant, anti-inflammatory, and potential anti-aging properties. | '''Quercetin''' has garnered substantial attention in the realm of longevity and health due to its multifaceted biological activities, including [[Antioxidant|antioxidant]], anti-inflammatory, and potential anti-aging properties. | ||
=== Summary of Key Findings=== | === Summary of Key Findings=== | ||
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== See Also == | == See Also == | ||
* | * {{SeeWikipedia|Quercetin}} | ||
== References == | == References == | ||
<references /> | <references /> | ||
[[Category:Orally Consumable Longevity | [[Category:Orally Consumable Longevity Compounds]] | ||
[[Category:Xenohormetic Compounds]] | |||
[[Category:Senolytic Compounds]] | |||
[[Category:Antioxidant Compounds]] | |||