Translations:Resveratrol/39/de: Difference between revisions

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Message definition (Resveratrol)

{| class="wikitable mw-collapsible mw-collapsed" style="width: 100%;"
|+Reported resveratrol plasma concentration in humans after repeated doses of resveratrol (studies after 2010). {{pmid|30641865}}
!Number of Participants, Characteristics, Study Type
!Dose<br>(mg/day)
!Days
!Administration
!Peak Plasma Concentration<br>(ng/mL)
|-
|6, low BMI
| rowspan="2" |2125
| rowspan="2" |11
| rowspan="2" |Tablet and drink
| 903.0
|-
|6, high BMI
|245.0
|-
| rowspan="4" |35, healthy males, cross-over study
| rowspan="4" |800
| rowspan="4" |5
|Capsule
|0.56
|-
|Dairy drink
| 0.61
|-
|Soy drink
|0.58
|-
|Protein-free drink
|0.70
|-
|7, healthy
|500
|28
|Capsule with Piperine
| 2967.25
|-
| rowspan="4" |40, healthy, repeated sequential dosing
|500
| rowspan="4" |29
| rowspan="4" |Caplet
|43.8
|-
| 1000
|141
|-
|2500
| 331
|-
|5000
|967
|-
|6, patients with hepatic metastases, randomized double-blind clinical trial
|5000
| 14
|Micronized resveratrol mixed in liquid
|1942
|-
|8, healthy subjects
|2000
|7
|Capsule
|1274
|-
| rowspan="3" |19, overweight or obese, randomized, double-blind, placebo-controlled, crossover intervention
|30
| rowspan="3" |6
| rowspan="3" |Capsule
|181.31
|-
|90
| 532.00
|-
|270
|1232.16
|}

Berichtete Resveratrol-Plasmakonzentrationen beim Menschen nach wiederholten Dosen von Resveratrol (Studien nach 2010). ^[1]
Anzahl der Teilnehmer, Merkmale, Studientyp	Dosis (mg/Tag)	Tage	Verabreichung	Spitzen-Plasmakonzentration (ng/mL)
6, niedriger BMI	2125	11	Tablette und Getränk	903,0
6, hoher BMI	2125	11	Tablette und Getränk	245,0
35, gesunde Männer, Cross-over-Studie	800	5	Kapsel	0,56
			Milchgetränk	0,61
			Sojagetränk	0,58
			Proteinfreies Getränk	0,70
7, gesund	500	28	Kapsel mit Piperin	2967,25
40, gesund, wiederholte sequenzielle Dosierung	500	29	Caplet	43,8
	1000			141
	2500			331
	5000			967
6, Patienten mit hepatischen Metastasen, randomisierte doppelblinde klinische Studie	5000	14	Mikronisiertes Resveratrol gemischt in Flüssigkeit	1942
8, gesunde Probanden	2000	7	Kapsel	1274
19, übergewichtig oder adipös, randomisierte, doppelblinde, placebokontrollierte, crossover Interventionsstudie	30	6	Kapsel	181,31
	90			532,00
	270			1232,16

↑ Springer M & Moco S: Resveratrol and Its Human Metabolites-Effects on Metabolic Health and Obesity. Nutrients 2019. (PMID 30641865) [PubMed] [DOI] [Full text] Resveratrol is one of the most widely studied polyphenols and it has been assigned a plethora of metabolic effects with potential health benefits. Given its low bioavailability and extensive metabolism, clinical studies using resveratrol have not always replicated in vitro observations. In this review, we discuss human metabolism and biotransformation of resveratrol, and reported molecular mechanisms of action, within the context of metabolic health and obesity. Resveratrol has been described as mimicking caloric restriction, leading to improved exercise performance and insulin sensitivity (increasing energy expenditure), as well as having a body fat-lowering effect by inhibiting adipogenesis, and increasing lipid mobilization in adipose tissue. These multi-organ effects place resveratrol as an anti-obesity bioactive of potential therapeutic use.

[pmid30641865-1] Springer M & Moco S: Resveratrol and Its Human Metabolites-Effects on Metabolic Health and Obesity. Nutrients 2019. (PMID 30641865) [PubMed] [DOI] [Full text] Resveratrol is one of the most widely studied polyphenols and it has been assigned a plethora of metabolic effects with potential health benefits. Given its low bioavailability and extensive metabolism, clinical studies using resveratrol have not always replicated in vitro observations. In this review, we discuss human metabolism and biotransformation of resveratrol, and reported molecular mechanisms of action, within the context of metabolic health and obesity. Resveratrol has been described as mimicking caloric restriction, leading to improved exercise performance and insulin sensitivity (increasing energy expenditure), as well as having a body fat-lowering effect by inhibiting adipogenesis, and increasing lipid mobilization in adipose tissue. These multi-organ effects place resveratrol as an anti-obesity bioactive of potential therapeutic use.

[1]

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-```mediawiki
 {| class="wikitable mw-collapsible mw-collapsed" style="width: 100%;"
-|+Berichtete Resveratrol-Plasmakonzentrationen beim Menschen nach wiederholten Dosen von Resveratrol (Studien nach 2010). {{#pmid:30641865|pmid30641865}}
+|+Berichtete Resveratrol-Plasmakonzentrationen beim Menschen nach wiederholten Dosen von Resveratrol (Studien nach 2010). {{pmid|30641865}}
 !Anzahl der Teilnehmer, Merkmale, Studientyp
 !Dosis<br>(mg/Tag)
@@ Line 77: / Line 76: @@
 |1232,16
 |}
-```