Trimethylglycine (TMG): Difference between revisions
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Trimethylglycine, commonly known as TMG or betaine, is an amino acid derivative that naturally occurs in various plant and animal sources. With its three methyl groups attached to a glycine molecule, TMG has garnered attention in both the dietary supplement market and the scientific community due to its role as a methyl donor in vital biochemical processes. | |||
Although trimethylglycine supplementation decreases the amount of [[wikipedia:Adipose_tissue|adipose tissue]] in pigs, research on human subjects has shown no effect on body weight, body composition, or resting energy expenditure when used in conjunction with a low calorie diet.<ref name="pmid12399266">{{cite journal|last1=Schwab|volume=76|doi-access=free|doi=10.1093/ajcn/76.5.961|pmid=12399266|date=November 2002|pages=961–967|issue=5|journal=Am. J. Clin. Nutr.|first1=U.|title=Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects|display-authors=etal|first3=L.|last3=Toppinen|first2=A.|last2=Törrönen|title-link=doi}}</ref> | Although trimethylglycine supplementation decreases the amount of [[wikipedia:Adipose_tissue|adipose tissue]] in pigs, research on human subjects has shown no effect on body weight, body composition, or resting energy expenditure when used in conjunction with a low calorie diet.<ref name="pmid12399266">{{cite journal|last1=Schwab|volume=76|doi-access=free|doi=10.1093/ajcn/76.5.961|pmid=12399266|date=November 2002|pages=961–967|issue=5|journal=Am. J. Clin. Nutr.|first1=U.|title=Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects|display-authors=etal|first3=L.|last3=Toppinen|first2=A.|last2=Törrönen|title-link=doi}}</ref> | ||
Revision as of 02:43, 21 September 2023
Trimethylglycine, commonly known as TMG or betaine, is an amino acid derivative that naturally occurs in various plant and animal sources. With its three methyl groups attached to a glycine molecule, TMG has garnered attention in both the dietary supplement market and the scientific community due to its role as a methyl donor in vital biochemical processes.
Although trimethylglycine supplementation decreases the amount of adipose tissue in pigs, research on human subjects has shown no effect on body weight, body composition, or resting energy expenditure when used in conjunction with a low calorie diet.[1]
Taking TMG
Side effects
Trimethylglycine supplementation may cause diarrhea, bloating, cramps, dyspepsia, nausea or vomiting.[2] Although rare, it can also causes excessive increases in serum methionine concentrations in the brain, which may lead to cerebral edema, a life-threatening condition.[2]
Trimethylglycine supplementation lowers homocysteine but also raises LDL-cholesterol in obese individuals and renal patients.[3]
References
- ↑ Schwab et al.; "Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects" , https://doi.org/10.1093/ajcn/76.5.961
- ↑ 2.0 2.1 "Betaine" , LiverTox: Clinical and Research Information on Drug-Induced Liver Injury , National Institute of Diabetes and Digestive and Kidney Diseases , http://www.ncbi.nlm.nih.gov/books/NBK548774/
- ↑ Olthof MR, van Vliet T, Verhoef P, Zock PL, Katan MB; "Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans" , https://doi.org/10.1371/journal.pmed.0020135