SIRT2

SIRT2, or sirtuin 2, is one of the members of the sirtuin family of proteins, which are class III histone deacetylases. The sirtuin family consists of seven members, SIRT1 to SIRT7, playing pivotal roles in cellular health, aging, and metabolism. SIRT2 has garnered significant attention due to its distinct cellular locations, versatile functions, and potential implications in various diseases, including neurodegenerative conditions and cancers.

In humans, SIRT2 is predominantly located in the cytoplasm, where it exhibits its deacetylase activity on a multitude of substrates. It’s crucial in maintaining cellular homeostasis, involved in processes such as the cell cycle, energy metabolism, and cellular differentiation. SIRT2’s role in these processes highlights its importance in understanding more about human biology, diseases, and aging.

Studying SIRT2 can provide crucial insights into the development of therapeutic strategies for numerous diseases, as modulation of its activity has demonstrated impactful results in cellular models. The pharmacological targeting of SIRT2 has thus become a focal point in research related to aging and age-related diseases.