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NAD+ Boosters: Difference between revisions
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NAD+ boosters are substances or interventions designed to increase levels of [[Nicotinamide Adenine Dinucleotide (NAD)|NAD+ (Nicotinamide Adenine Dinucleotide)]], a critical coenzyme found in every cell, essential for cellular energy production, metabolism, and repair processes. Boosting NAD+ levels is of significant interest in the fields of health and longevity, as declining levels of NAD+ are associated with aging and various age-related diseases. | NAD+ boosters are substances or interventions designed to increase levels of [[Nicotinamide Adenine Dinucleotide (NAD)|NAD+ (Nicotinamide Adenine Dinucleotide)]], a critical coenzyme found in every cell, essential for cellular energy production, metabolism, and repair processes. Boosting NAD+ levels is of significant interest in the fields of health and longevity, as declining levels of NAD+ are associated with aging and various age-related diseases. | ||
== NAD+ Precursors == | == Overview of NAD+ Boosters == | ||
=== NAD+ Precursors === | |||
[[NAD+ Precursor|NAD+ precursors]] are molecules that serve as substrates in the biosynthesis of NAD+. They can be converted into NAD+ within the body, thus serving as effective NAD+ boosters. | [[NAD+ Precursor|NAD+ precursors]] are molecules that serve as substrates in the biosynthesis of NAD+. They can be converted into NAD+ within the body, thus serving as effective NAD+ boosters. | ||
* '''[[Nicotinamide Mononucleotide (NMN)]]:''' A molecule that can directly stimulate NAD+ synthesis, playing a crucial role in energy metabolism and cell vitality. | * '''[[Nicotinamide Mononucleotide (NMN)]]:''' A molecule that can directly stimulate NAD+ synthesis, playing a crucial role in energy metabolism and cell vitality. | ||
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* '''[[Nicotinamide (NAM)]]:''' A form of vitamin B3, acts as an NAD+ precursor via the NAD+ salvage pathway. | * '''[[Nicotinamide (NAM)]]:''' A form of vitamin B3, acts as an NAD+ precursor via the NAD+ salvage pathway. | ||
== Boosting NAD+ by Inhibiting NAD+ Consumers == | === Boosting NAD+ by Inhibiting NAD+ Consumers === | ||
NAD+ consumers are enzymes that use NAD+ as a substrate, reducing the available NAD+ in the cell. By inhibiting these consumers, more NAD+ remains available for other cellular processes. | NAD+ consumers ([[NADase]]) are enzymes that use NAD+ as a substrate, reducing the available NAD+ in the cell. By inhibiting these consumers, more NAD+ remains available for other cellular processes. | ||
* '''[[Sirtuins]]:''' A family of proteins that deacetylate proteins and consume NAD+ in the process. Compounds like resveratrol can activate sirtuins and the subsequent cellular effects can create an environment where cells might maintain or produce NAD+ more efficiently, which could indirectly support NAD+ availability. | * '''[[Sirtuins]]:''' A family of proteins that deacetylate proteins and consume NAD+ in the process. Compounds like resveratrol can activate sirtuins and the subsequent cellular effects can create an environment where cells might maintain or produce NAD+ more efficiently, which could indirectly support NAD+ availability. | ||
* '''PARPs (Poly(ADP-ribose) polymerases):''' Enzymes involved in DNA repair that also consume NAD+. Inhibiting PARP activity can help maintain NAD+ levels. | * '''PARPs (Poly(ADP-ribose) polymerases):''' Enzymes involved in DNA repair that also consume NAD+. Inhibiting PARP activity can help maintain NAD+ levels. | ||
* '''CD38:''' A glycoprotein that uses NAD+; reducing CD38 levels or activity can potentially elevate NAD+ levels. | * '''CD38:''' A glycoprotein that uses NAD+; reducing CD38 levels or activity can potentially elevate NAD+ levels. | ||
== Other NAD+ Boosting | === Other NAD+ Boosting Molecules === | ||
Beyond precursors and inhibitors of NAD+ consumers, several other supplements claim to boost NAD+ levels or improve NAD+ metabolism. | Beyond precursors and inhibitors of NAD+ consumers, several other supplements claim to boost NAD+ levels or improve NAD+ metabolism. | ||
* '''[[Resveratrol]]:''' While primarily known as a sirtuin activator, it might also have indirect effects on NAD+ levels and metabolism. | * '''[[Resveratrol]]:''' While primarily known as a sirtuin activator, it might also have indirect effects on NAD+ levels and metabolism. | ||
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* '''[[Pterostilbene]]:''' A polyphenol, similar to resveratrol, purported to have beneficial effects on NAD+ metabolism and sirtuin activation. | * '''[[Pterostilbene]]:''' A polyphenol, similar to resveratrol, purported to have beneficial effects on NAD+ metabolism and sirtuin activation. | ||
== Interventions to Boost NAD+ == | === Interventions to Boost NAD+ === | ||
Apart from supplements, certain lifestyle and dietary interventions may also support NAD+ levels. | Apart from supplements, certain lifestyle and dietary interventions may also support NAD+ levels. | ||
* '''[[Exercise]]:''' Regular physical activity has been shown to increase NAD+ levels, likely due to enhanced energy metabolism and increased demand for ATP. | * '''[[Exercise]]:''' Regular physical activity has been shown to increase NAD+ levels, likely due to enhanced energy metabolism and increased demand for ATP. | ||