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Nicotinamide Mononucleotide (NMN): Difference between revisions
Nicotinamide Mononucleotide (NMN) (view source)
Revision as of 07:35, 29 September 2023
, 29 September 2023→Dosage and Effects
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=== Dosage and Effects === | === Dosage and Effects === | ||
Human studies have indicated that a dosage of 1000 mg over 10 days can raise NAD levels about two-fold, and dosages as high as 2000 mg can triple the amount. However, the long-term safety, efficacy, and optimal dosage of NMN are still under investigation, and more comprehensive studies are needed to establish concrete guidelines for NMN supplementation. {{Citation needed}} | Human studies have indicated that a dosage of 1000 mg over 10 days can raise NAD levels about two-fold, and dosages as high as 2000 mg can triple the amount. However, the long-term safety, efficacy, and optimal dosage of NMN are still under investigation, and more comprehensive studies are needed to establish concrete guidelines for NMN supplementation. {{Citation needed}} | ||
===Risks of NMN Supplementation=== | |||
While NMN supplementation holds promise due to its potential anti-aging benefits and ability to enhance cellular metabolism, it is crucial to be aware of the potential risks involved. Here are some risks and considerations based on current knowledge and research: | |||
* '''Limited Human Studies:''' Most of the studies on NMN have been conducted in animal models, and there is limited data on its effects in humans. Therefore, the safety and efficacy of NMN supplementation in humans are not fully understood, and caution is advised until more research is conducted. | |||
* '''Potential Interaction with Medications''': The interaction of NMN with various medications is not well studied, and there could be potential risks when combined with certain drugs. Individuals on medication should consult with a healthcare professional before considering NMN supplementation. | |||
* '''Theoretical Concerns''': There are theoretical concerns regarding NMN’s potential to deplete methyl groups in the body, which could impact various biological processes, including DNA methylation and neurotransmitter synthesis. While this is a theoretical concern and not substantiated by concrete evidence, it is important to consider when evaluating the potential risks of NMN supplementation.{{Citation needed}} | |||
* '''Over-Supplementation Risks''': Excessive supplementation of NMN may lead to unknown side effects due to the lack of long-term human studies. Over-supplementation might also disrupt the natural balance of NAD+ and its related compounds in the body, potentially leading to unforeseen consequences. | |||
* '''Purity and Quality Concerns''': The purity and quality of NMN supplements can vary, and impurities or contaminants in the supplements pose additional risks. It is essential to choose high-quality, reputable brands and sources for NMN supplements to minimize risks associated with impurities and contaminants. | |||
== Clinical Trials == | == Clinical Trials == | ||