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Spermidine: Difference between revisions
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Spermidine is a polyamine compound found in living tissues and is known for its role in cellular function and development. It has been increasingly recognized for its potential health benefits, particularly concerning longevity and age-related diseases. Studies have indicated that spermidine has the ability to promote autophagy, the body's intracellular recycling mechanism, which is crucial for cellular maintenance, homeostasis, and overall health. | Spermidine is a polyamine compound found in living tissues and is known for its role in cellular function and development. It has been increasingly recognized for its potential health benefits, particularly concerning longevity and age-related diseases. Studies have indicated that spermidine has the ability to promote autophagy, the body's intracellular recycling mechanism, which is crucial for cellular maintenance, homeostasis, and overall health. | ||
Spermidine is a naturally occurring biogenic polyamine, synthesized from the amino acid ornithine through the action of the enzyme ornithine decarboxylase (ODC). It is involved in various fundamental biological processes, including DNA stability, RNA transcription, translation, enzyme function, and cell proliferation. As a cellular polyamine, spermidine is essential for both normal and neoplastic tissue growth and is found in all eukaryotic cells. | Spermidine is a naturally occurring biogenic polyamine, synthesized from the amino acid ornithine through the action of the enzyme ornithine decarboxylase (ODC). It is involved in various fundamental biological processes, including DNA stability, RNA transcription, translation, enzyme function, and cell proliferation. As a cellular polyamine, spermidine is essential for both normal and neoplastic tissue growth and is found in all eukaryotic cells. | ||
== Dietary Sources == | == Dietary Sources == | ||
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Considering a balanced diet that includes these foods can increase spermidine intake, which, in light of recent research, could be beneficial for health and longevity. | Considering a balanced diet that includes these foods can increase spermidine intake, which, in light of recent research, could be beneficial for health and longevity. | ||
== Spermidine and Longevity == | |||
Research has identified a significant correlation between the exogenous supplementation of spermidine and increased lifespan in several model organisms such as yeast, worms, flies, and mice. The longevity-promoting properties of spermidine are primarily attributed to its role in inducing autophagy. | |||
=== Autophagy === | |||
Autophagy is a cellular process involved in the degradation and recycling of obsolete or dysfunctional cellular components. This mechanism is vital for maintaining cellular homeostasis and plays a central role in cell and tissue health. Spermidine's ability to enhance autophagy is of particular interest in the context of aging, as the decline in autophagy has been associated with several age-related pathologies, including neurodegeneration, cardiovascular disease, and cancer. | |||
Spermidine promotes autophagy through the inhibition of the acetyltransferase EP300, leading to hypolysine acetylation of the protein eIF5A, among other targets, and consequently inducing autophagic processes. The upregulation of autophagy is believed to alleviate the phenotypic characteristics of aging within cells, thus promoting cellular longevity. | |||
=== Cardiovascular Health === | |||
Apart from its role in autophagy, spermidine has been observed to contribute to cardiovascular health. Dietary spermidine intake is linked to reduced blood pressure and decreased risk of heart disease, potentially due to its ability to induce autophagy in cardiac myocytes, thus preventing the onset of heart failure and other related conditions. | |||
== Safety and Dosage == | == Safety and Dosage == | ||