Creatine

Creatine is a well-known dietary supplement, popular among athletes for its ability to enhance physical performance in high-intensity, short-duration activities. Apart from its performance-enhancing benefits, recent studies and analysis also hint at creatine's potential advantages concerning longevity and aging.

Forms of Creatine

There are several forms of creatine available in the market, with Creatine Monohydrate being the most common and well-studied form. Other forms include Creatine Ethyl Ester, Creatine Hydrochloride, Creatine Malate, Creatine Citrate, Buffered Creatine (Kre-Alkalyn), Creatine Nitrate, and Creatine Magnesium Chelate.

Cognitive Function

Older adults supplementing with creatine have shown improvements in tasks of memory and cognition. The cognition-enhancing effects of creatine are particularly significant in tasks requiring rapid speed of processing. Creatine supplementation has also improved performance in complex executive tasks during extended sleep deprivation.

Cardiovascular Health

Creatine supplementation has shown promise in enhancing cardiac muscle performance. In animal studies, creatine restored ATP levels under cardiac stress conditions and reduced markers of heart muscle exhaustion. Human studies, although limited, have also shown promising results in improving cardiac performance in patients with chronic congestive heart failure.

Blood Sugar Regulation

Creatine supplementation has shown potential in managing blood sugar levels by increasing the body's ability to utilize glucose as metabolic fuel. This is particularly beneficial for diabetic individuals. Studies have shown creatine supplementation alongside moderate exercise improves oral glucose tolerance test results, indicating creatine's potential benefit in blood sugar regulation.

Muscle Retention

Creatine supplementation can counteract sarcopenia, the loss of muscle mass associated with aging, by enhancing lean body mass, muscular performance, and fatigue resistance. Supplementation with creatine has shown significant improvements in high-energy actions and grip strength, even in the absence of exercise training. This is crucial in reducing the risks associated with falls and serious injuries in older adults.

Safety and Performance Enhancement

A double-blind placebo-controlled study conducted in 2020 evaluated creatine monohydrate supplementation's effect on various health indicators in resistance training practitioners. The participants were supplemented with 0.3 g/kg (24g for 80kg) per day creatine monohydrate for 7 days. The study found that creatine monohydrate supplementation promoted an increase in performance and body weight, without causing any adverse events. No modifications were observed in a panel of blood and urine health indicators including red and white blood cell parameters, blood lipid profile, metabolic and urine markers, hepatic and renal function, indicating the safety of creatine monohydrate supplementation for health.

Potential Longevity Benefits

In animal studies, creatine supplementation has been associated with a 9% increase in lifespan. Creatine-fed mice also demonstrated significantly better performance on neurobehavioral testing. While human trials are needed to confirm these findings, they suggest a potential benefit of creatine supplementation for longevity.

Conclusion

Creatine supplementation presents a promising avenue for enhancing various aspects of health and possibly longevity, particularly concerning cognitive function, cardiovascular health, blood sugar regulation, and muscle retention. While the evidence is growing, further research, especially large-scale human trials, are required to better understand the full spectrum of creatine's benefits on longevity.