Rats (Rattus Norvegicus): Difference between revisions
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! Strain | ! Strain | ||
! Characteristics | ! Characteristics | ||
! Typical Lifespan | |||
! Prone Diseases | |||
! Notable Research Findings | |||
! Relevance to Longevity Research | ! Relevance to Longevity Research | ||
|- | |- | ||
| [[Wistar rats|Wistar]] | | [[Wistar rats|Wistar]] | ||
| General-purpose strain, albino coat | | General-purpose strain, albino coat | ||
| 2-3 years | |||
| Kidney diseases, tumors | |||
| Extensively studied in toxicology and pharmacology | |||
| Commonly used in aging studies due to well-documented lifespan | | Commonly used in aging studies due to well-documented lifespan | ||
|- | |- | ||
| [[Sprague Dawley rats|Sprague Dawley]] | | [[Sprague Dawley rats|Sprague Dawley]] | ||
| Outbred, albino, large size | | Outbred, albino, large size | ||
| 2-2.5 years | |||
| Heart disease, diabetes | |||
| Often used in cancer research | |||
| Popular for age-related disease studies | | Popular for age-related disease studies | ||
|- | |- | ||
| Brown Norway | | Brown Norway | ||
| Inbred, brown coat, long lifespan | | Inbred, brown coat, long lifespan | ||
| 3-3.5 years | |||
| Less prone to cancer, but susceptible to respiratory disease | |||
| Studies have shown exceptional aging characteristics | |||
| Known for its exceptionally long lifespan, useful for studying aging processes | | Known for its exceptionally long lifespan, useful for studying aging processes | ||
|- | |- | ||
| Fischer 344 | | Fischer 344 | ||
| Inbred, albino, prone to certain age-related diseases | | Inbred, albino, prone to certain age-related diseases | ||
| 2-2.5 years | |||
| High incidence of leukemia, immune system decline | |||
| Common model for immunosenescence studies | |||
| Frequently used in gerontology for studying age-related pathologies | | Frequently used in gerontology for studying age-related pathologies | ||
|- | |- | ||
| Long-Evans | | Long-Evans | ||
| Outbred, hooded coat, good healthspan | | Outbred, hooded coat, good healthspan | ||
| 2-3 years | |||
| Obesity, neurological disorders | |||
| Used in behavioral and obesity research | |||
| Utilized in research focusing on the quality of life and health in old age | | Utilized in research focusing on the quality of life and health in old age | ||
|- | |- | ||
| SHR (Spontaneously Hypertensive Rat) | | SHR (Spontaneously Hypertensive Rat) | ||
| Inbred, used in cardiovascular research | | Inbred, used in cardiovascular research | ||
| 1.5-2 years | |||
| Cardiovascular diseases, stroke | |||
| Key model in hypertension and stroke research | |||
| Valuable for studying the interplay between hypertension and aging | | Valuable for studying the interplay between hypertension and aging | ||
|} | |} | ||
Latest revision as of 03:45, 8 December 2023
Laboratory rats or lab rats are strains of the rat subspecies Rattus norvegicus domestica which are bred and kept for scientific research. While less commonly used for research than laboratory mice, rats have served as an important animal model for research in psychology and biomedical science.[1]
Strains used in Longevity Research
| Strain | Characteristics | Typical Lifespan | Prone Diseases | Notable Research Findings | Relevance to Longevity Research |
|---|---|---|---|---|---|
| Wistar | General-purpose strain, albino coat | 2-3 years | Kidney diseases, tumors | Extensively studied in toxicology and pharmacology | Commonly used in aging studies due to well-documented lifespan |
| Sprague Dawley | Outbred, albino, large size | 2-2.5 years | Heart disease, diabetes | Often used in cancer research | Popular for age-related disease studies |
| Brown Norway | Inbred, brown coat, long lifespan | 3-3.5 years | Less prone to cancer, but susceptible to respiratory disease | Studies have shown exceptional aging characteristics | Known for its exceptionally long lifespan, useful for studying aging processes |
| Fischer 344 | Inbred, albino, prone to certain age-related diseases | 2-2.5 years | High incidence of leukemia, immune system decline | Common model for immunosenescence studies | Frequently used in gerontology for studying age-related pathologies |
| Long-Evans | Outbred, hooded coat, good healthspan | 2-3 years | Obesity, neurological disorders | Used in behavioral and obesity research | Utilized in research focusing on the quality of life and health in old age |
| SHR (Spontaneously Hypertensive Rat) | Inbred, used in cardiovascular research | 1.5-2 years | Cardiovascular diseases, stroke | Key model in hypertension and stroke research | Valuable for studying the interplay between hypertension and aging |
See Also
- Wikipedia - Laboratory rat
References
- ↑ Vandenbergh; "Use of House Mice in Biomedical Research" , https://doi.org/10.1093/ilar.41.3.133