Dr. David Sinclair: Difference between revisions

    From Longevity Wiki
    VisualWikitext
     
    (110 intermediate revisions by the same user not shown)
    Line 1: Line 1:
    '''David Andrew Sinclair''' AO (born June 26, 1969) is an Australian-American biologist and academic known for his research on aging and epigenetics. Sinclair is a professor of genetics at Harvard Medical School and is the co-director of its Paul F. Glenn Center for Biology of Aging Research. He is the president of the non-profit Academy for Health & Lifespan Research and an officer of the Order of Australia (AO).
    [[File:David Sinclair.jpg|alt=|thumb|Sinclair in 2020]]
    '''David Andrew Sinclair''' (born June 26, 1969) is an Australian biologist and professor of genetics best known for his research on aging and longevity. He is a Professor at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. Sinclair is also a co-founder of several biotechnology companies and is known for his advocacy of using genetic and other therapies to combat aging.
    == Early Life and Education ==
    David Sinclair was born in Australia in 1969. He received his Bachelor of Science (BSc) at the University of New South Wales (UNSW) in Sydney, Australia, where he also completed a Ph.D. in Molecular Genetics under the guidance of Ian Dawes, graduating in 1995. His doctoral research involved studies on gene regulation in yeast, which is a [[Model Organism|model organism]] in aging research due to its short lifespan and well-documented genome.
    ==Career and Research ==
    After completing his Ph.D., Sinclair received a postdoctoral fellowship at the Massachusetts Institute of Technology (MIT) in the lab of Leonard Guarente, where he studied the role of [[Sirtuins|sirtuins]] in aging, particularly the yeast protein [[SIRT2|Sir2]] which was linked to the regulation of lifespan in several [[Model Organism|model organisms]]. His research has contributed to the understanding of how sirtuins are activated by the compound [[Resveratrol|resveratrol]], found in red wine, which has been associated with extended lifespan in animal models.


    == Substances Taken by David A. Sinclair ==
    Sinclair joined the faculty of Harvard Medical School in the early 2000s. His research group focuses on understanding the biological mechanisms of aging and developing new interventions to slow its process. They have identified several chemical compounds, including the [[NAD+ Precursor|NAD+ precursor]] [[Nicotinamide Mononucleotide (NMN)|nicotinamide mononucleotide (NMN)]], that appear to mitigate some effects of aging in animal models.
    === Current ===
    === Sirtuins in Aging===
    {| class="wikitable"
    Sinclair's research has significantly focused on the sirtuin family of protein deacetylases, which are thought to be responsible for the lifespan-extending properties of diets such as caloric restriction in various species. His lab has published extensively on the biochemistry of sirtuins and their role in DNA repair, metabolism, and mitochondrial function, among other cellular processes critical to the aging pathway.
    |+
    ===NAD+ and Aging===
    !Substance
    Another major focus of Sinclair's research is the role of [[NAD+|NAD+ (nicotinamide adenine dinucleotide)]] in aging. NAD+ is a coenzyme found in all living cells that is involved in redox reactions. Sinclair's lab has shown that NAD+ levels decline with age in various organisms and that supplementing older mice with an NAD+ precursor can rejuvenate aspects of aging at a cellular and physiological level.
    !Dose
    ==Public Advocacy and Business Ventures==
    !When
    Beyond his academic research, David Sinclair is an advocate for translating aging research into medical applications. He has co-founded several biotechnology companies, including Sirtris Pharmaceuticals, which focused on resveratrol formulations and sirtuin-activating compounds, and was later acquired by GlaxoSmithKline. He is also involved with companies working on NAD+ boosting molecules and other technologies meant to combat aging.
    |-
    |[[Nicotinamid Mononukleotid (NMN)]]
    |1000 mg
    |Morning
    |-
    |[[Resveratrol]]
    |1000 mg
    |Morning
    |-
    |[[Metformin]]
    |800 mg
    |Evening (not when he making excercise and muscles are growing)
    |-
    |[[Spermidine]]
    |1000 mg
    |Morning
    |-
    |[[Quercetin]]
    |500 mg
    |Morning
    |-
    |[[Fisetin]]
    |500 mg
    |Morning
    |-
    |[[Vitamin D3]]
    |4,000 to 5,000 IUs
    |
    |-
    |[[Vitamin K3]]
    |180 to 360 mcg
    |
    |-
    |Low-Dose [[Aspirin]]
    |83 mg
    |
    |-
    |[[Trimethylglycine (TMG)]]
    |500 - 1000 mg
    |
    |-
    |[[Alpha Lipoic Acid (ALA)]]
    |Recent status unknown
    |
    |-
    |[[Coenzyme Q10 (coQ10)]]
    |Recent status unknown
    |
    |}


    === Previously ===
    Sinclair is the author of the book ''[[Lifespan: Why We Age – and Why We Don't Have To]],'' published in September 2019, where he discusses his view of aging as a disease that can be treated to extend human healthspan and lifespan.
    {| class="wikitable"
    ==Awards and Recognition==
    |+
    Sinclair has received numerous awards for his research on aging. Some of his accolades include the Australian Commonwealth Prize, the American Association for Aging Research’s Innovator Award, and being named to Time Magazine’s list of the "100 most influential people" in the world.
    !
    !{{VerticalText|NMN}}
    !{{VerticalText|Reseratrol}}
    !{{VerticalText|Metformin}}
    |-
    |
    |
    |
    |
    |-
    |
    |
    |
    |
    |-
    |
    |
    |
    |
    |}


    == Interviews ==
    David is vegan since at least December 2021 <ref>[[2021-12-27 - Interview Dr. David Sinclair - Huberman Lab Podcast - The Biology of Slowing & Reversing Aging]]</ref>.


    * [[14.01.2022 - Interview Dr. David Sinclair - Reverse Your Age: What To Eat & When To Eat For LONGEVITY]]
    == Personal Approaches and Views on Anti-Aging==


    == See also ==
    David Sinclair is known not just for his professional research into aging but also for his personal commitment to the field, often referring to himself as a "guinea pig" for anti-aging research. His approach is grounded in the belief that scientific knowledge is most powerful when it is experienced firsthand, a principle he applies by personally trying out therapies and interventions that emerge from longevity research. <ref>[[2022-12-29 - Interview Dr. David Sinclair - Moonshots with Peter Diamandis - Age Reversal Breakthroughs, FDA Approval, and Living Forever]]</ref>


    * [[Wikipedia:David A. Sinclair|Wikipedia article]]
    ===Experiential Scientific Philosophy===
    Sinclair adheres to an experiential form of scientific inquiry, often discussing his willingness to personally try interventions and treatments before discussing them publicly. He believes that firsthand experience is crucial if he's to speak authentically and authoritatively about his findings or suggestions, despite not being a medical doctor but a Ph.D. holder. He has clarified, however, that his discussions about his experiences are not endorsements or recommendations, acknowledging the limits of his professional domain.


    ===Commitment to Transparency===
    Despite potential accusations of bias due to his personal use of molecules and treatments studied in his lab, Sinclair asserts a commitment to transparency. He argues that his and his family's personal use of these treatments motivates him to rigorously search for potential problems. He is driven by a responsibility to identify and announce any adverse effects or issues, prioritizing public health and safety. This commitment extends to his readiness to be the first to report any problems, reaffirming his position of responsibility within the anti-aging research community.
    ===Personal Anti-Aging Regimen===
    Sinclair has been open about his personal anti-aging regimen, which includes the use of molecules like resveratrol and NAD+ precursors, reflecting his research interests. He also pays attention to emerging treatments and compounds within the field. For instance, he has mentioned his consideration of rapamycin, a drug known for its potential anti-aging effects, discussing the importance of risk-reward analysis in deciding whether to use such interventions.
    === Views on Aging as a Risk===
    A foundational aspect of Sinclair's perspective on anti-aging research and intervention is the view of aging itself as a significant risk. He often discusses how society tends to underestimate the risks associated with aging, failing to treat it with as much urgency as other health issues. For Sinclair, the ultimate goal of anti-aging research isn't just to prolong life but to mitigate the myriad risks associated with aging, which he quips is "known to cause death" and is a condition that "runs in families," using humor to underline the universal nature of aging.
    == Supplement Protocol==
    In his book [[Lifespan: Why We Age – and Why We Don't Have To]], he disclosed in 2019 that he is taking daily [[Nicotinamide Mononucleotide (NMN)|NMN]], [[Resveratrol|resveratrol]], metformin, [[Aspirin|aspirin]], [[Vitamin D3|vitamin D3]] and [[Vitamin K2|vitamin K2]]. In the meanwhile, he has added several other compound to this protocol like [[Spermidine]], [[Quercetin]], [[Alpha Lipoic Acid (ALA)]], etc.
    {{See|Dr. David Sinclair's Supplement Protocol}} for a full list of supplements.
    ==Videos==
    ===Produced by David Sinclair===
    ==== Podcasts====
    *[[2022-01-05 - Podcast Dr. David Sinclair - The Science Behind Why We Age]]
    *[[2022-01-12 - Podcast Dr. David Sinclair - What to Eat & When to Eat for Longevity]]
    *[[2022-01-19 - Podcast Dr. David Sinclair - Exercise, Heat, Cold & Other Stressors for Longevity]]
    *[[2022-01-26 - Podcast Dr. David Sinclair - NMN, NR, Resveratrol, Metformin & Other Longevity Molecules]]
    *[[2022-02-02 - Podcast Dr. David Sinclair - Medical Interventions (TRT, HGH, Stem Cells, etc.) For Longevity]]
    *[[2022-02-09 - Podcast Dr. David Sinclair - The Science of Looking Younger, Longer]]
    *[[2022-02-16 - Podcast Dr. David Sinclair - The Science of Keeping the Brain Healthy]]
    *[[2022-02-23 - Podcast Dr. David Sinclair - Biotracking, Age Reversal & Other Advanced Health Technologies]]
    ===Longevity Lifestyle Series with Serena Poon===
    In August 2022 David Sinclair and Serena Poon startet the [https://www.youtube.com/@optimizelongevity/ Optimize Longevity YouTube Channel] that is all about tips for improving the quality of life and extending the lifespan.
    Season 1
    *[[2022-08-28 - Interview Dr. David Sinclair - Optimize Longevity - Aging: DNA is not your destiny. Food is]]
    *[[2022-08-30 - Interview Dr. David Sinclair - Optimize Longevity - What To Eat & When For Longevity]]
    *[[2022-08-31 - Interview Dr. David Sinclair - Optimize Longevity - Longevity Molecules and Supplements]]
    *[[2022-09-01 - Interview Dr. David Sinclair - Optimize Longevity - The Science of Looking Younger Longer]]
    *[[2022-09-02 - Interview Dr. David Sinclair - Optimize Longevity - Keeping Your Brain Young]]
    Season 2
    *[[2023-05-03 - Interview Dr. David Sinclair - Optimize Longevity - Personalizing Your Fasting Window]]
    *[[2023-05-13 - Interview Dr. David Sinclair - Optimize Longevity - Gut Health for Longevity]]
    *[[2023-05-19 - Interview Dr. David Sinclair - Optimize Longevity - Ask Us Anything]]
    Season 3
    *[[2023-07-17 - Interview Dr. David Sinclair - Optimize Longevity - Build Muscle & Maintain Longevity]]
    ===Interviews and Talks===
    *[[2019-09-01 - Interview Dr. David Sinclair - Dr. Mercola interviews Dr. David Sinclair on Extending Your "Lifespan"]]
    *[[2020-01-30 - Talk Dr. David Sinclair - IVY Masterclass - How to Extend Your Lifespan with David Sinclair]]
    *[[2021-06-07 - Interview Dr. David Sinclair - Lex Fridman Podcast - Extending the Human Lifespan Beyond 100 Years]]
    *[[2021-12-27 - Interview Dr. David Sinclair - Huberman Lab Podcast - The Biology of Slowing & Reversing Aging]]
    *[[2021-12-31 - Interview Dr. David Sinclair - mindbodygreen - How to look & feel 15 years younger]]
    *[[2022-01-14 - Interview Dr. David Sinclair - Reverse Your Age: What To Eat & When To Eat For LONGEVITY]]
    *[[2022-02-11 - Interview Dr. David Sinclair - REVERSE AGING: What To Eat & When To Eat To INCREASE LONGEVITY]]
    *[[2022-05-03 - Interview Dr. David Sinclair - Knowledge Project - How to Not Die]]
    *[[2022-06-09 - Interview Dr. David Sinclair - Tom Bilyeu - The DAILY HACKS To Look Younger, Live Longer & REVERSE YOUR AGE]]
    *[[2022-10-24 - Presentation Dr. David Sinclair - ARDD2022 - Great release of unpublished data from David Sinclair's Lab]]
    *[[2022-12-29 - Interview Dr. David Sinclair - Moonshots and Mindsets - Why Aging is a Disease With David Sinclair]]
    *[[2022-12-29 - Interview Dr. David Sinclair - Moonshots with Peter Diamandis - Age Reversal Breakthroughs, FDA Approval, and Living Forever]]
    *[[2023-03-18 - Interview Dr. David Sinclair - India Today - Exclusive Conversation With Geneticist & Harvard Professor David Sinclair]]
    *[[2023-06-26 - Interview Dr. David Sinclair - The Longevity Experts - Why We Don't Have to Age & How to Fight Aging]]
    *[[2023-04-13 - Talk Dr. David Sinclair - Majlis Lecture Series - ‏Why We Age and Why We Don't Have To]]
    *[[2023-07-02 - Interview Dr. David Sinclair - The Longevity Experts - The Harvard Scientist's Anti-Aging Protocol]]
    *[[2023-07-04 - Interview Dr. David Sinclair - The Longevity Experts - Aging is NOT Unstoppable (2023 Edition)]]
    *[[2023-07-14 - Interview Dr. David Sinclair - mindbodygreen - AGING is a disease we can REVERSE]]
    *[[2023-07-19 - Talk Dr. David Sinclair - BIOHACK 2.0 - How To Live LONGER & AGE BETTER]]
    *[[2023-07-22 - Interview Dr. David Sinclair - Reversing Aging: The Revolutionary Discoveries of David Sinclair]]
    *[[2023-08-24 - Interview Dr. David Sinclair - Moonshots with Peter Diamandis - Aging is Now Optional (Abundance360)]]
    ==See also==
    *[[Dr. David Sinclair's Supplement Protocol]]
    *{{SeeWikipedia|David A. Sinclair}}
    ==References==
    <references />
    [[Category:People]]
    [[Category:People]]

    Latest revision as of 00:54, 8 January 2024

    Sinclair in 2020

    David Andrew Sinclair (born June 26, 1969) is an Australian biologist and professor of genetics best known for his research on aging and longevity. He is a Professor at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. Sinclair is also a co-founder of several biotechnology companies and is known for his advocacy of using genetic and other therapies to combat aging.

    Early Life and Education

    David Sinclair was born in Australia in 1969. He received his Bachelor of Science (BSc) at the University of New South Wales (UNSW) in Sydney, Australia, where he also completed a Ph.D. in Molecular Genetics under the guidance of Ian Dawes, graduating in 1995. His doctoral research involved studies on gene regulation in yeast, which is a model organism in aging research due to its short lifespan and well-documented genome.

    Career and Research

    After completing his Ph.D., Sinclair received a postdoctoral fellowship at the Massachusetts Institute of Technology (MIT) in the lab of Leonard Guarente, where he studied the role of sirtuins in aging, particularly the yeast protein Sir2 which was linked to the regulation of lifespan in several model organisms. His research has contributed to the understanding of how sirtuins are activated by the compound resveratrol, found in red wine, which has been associated with extended lifespan in animal models.

    Sinclair joined the faculty of Harvard Medical School in the early 2000s. His research group focuses on understanding the biological mechanisms of aging and developing new interventions to slow its process. They have identified several chemical compounds, including the NAD+ precursor nicotinamide mononucleotide (NMN), that appear to mitigate some effects of aging in animal models.

    Sirtuins in Aging

    Sinclair's research has significantly focused on the sirtuin family of protein deacetylases, which are thought to be responsible for the lifespan-extending properties of diets such as caloric restriction in various species. His lab has published extensively on the biochemistry of sirtuins and their role in DNA repair, metabolism, and mitochondrial function, among other cellular processes critical to the aging pathway.

    NAD+ and Aging

    Another major focus of Sinclair's research is the role of NAD+ (nicotinamide adenine dinucleotide) in aging. NAD+ is a coenzyme found in all living cells that is involved in redox reactions. Sinclair's lab has shown that NAD+ levels decline with age in various organisms and that supplementing older mice with an NAD+ precursor can rejuvenate aspects of aging at a cellular and physiological level.

    Public Advocacy and Business Ventures

    Beyond his academic research, David Sinclair is an advocate for translating aging research into medical applications. He has co-founded several biotechnology companies, including Sirtris Pharmaceuticals, which focused on resveratrol formulations and sirtuin-activating compounds, and was later acquired by GlaxoSmithKline. He is also involved with companies working on NAD+ boosting molecules and other technologies meant to combat aging.

    Sinclair is the author of the book Lifespan: Why We Age – and Why We Don't Have To, published in September 2019, where he discusses his view of aging as a disease that can be treated to extend human healthspan and lifespan.

    Awards and Recognition

    Sinclair has received numerous awards for his research on aging. Some of his accolades include the Australian Commonwealth Prize, the American Association for Aging Research’s Innovator Award, and being named to Time Magazine’s list of the "100 most influential people" in the world.

    David is vegan since at least December 2021 [1].

    Personal Approaches and Views on Anti-Aging

    David Sinclair is known not just for his professional research into aging but also for his personal commitment to the field, often referring to himself as a "guinea pig" for anti-aging research. His approach is grounded in the belief that scientific knowledge is most powerful when it is experienced firsthand, a principle he applies by personally trying out therapies and interventions that emerge from longevity research. [2]

    Experiential Scientific Philosophy

    Sinclair adheres to an experiential form of scientific inquiry, often discussing his willingness to personally try interventions and treatments before discussing them publicly. He believes that firsthand experience is crucial if he's to speak authentically and authoritatively about his findings or suggestions, despite not being a medical doctor but a Ph.D. holder. He has clarified, however, that his discussions about his experiences are not endorsements or recommendations, acknowledging the limits of his professional domain.

    Commitment to Transparency

    Despite potential accusations of bias due to his personal use of molecules and treatments studied in his lab, Sinclair asserts a commitment to transparency. He argues that his and his family's personal use of these treatments motivates him to rigorously search for potential problems. He is driven by a responsibility to identify and announce any adverse effects or issues, prioritizing public health and safety. This commitment extends to his readiness to be the first to report any problems, reaffirming his position of responsibility within the anti-aging research community.

    Personal Anti-Aging Regimen

    Sinclair has been open about his personal anti-aging regimen, which includes the use of molecules like resveratrol and NAD+ precursors, reflecting his research interests. He also pays attention to emerging treatments and compounds within the field. For instance, he has mentioned his consideration of rapamycin, a drug known for its potential anti-aging effects, discussing the importance of risk-reward analysis in deciding whether to use such interventions.

    Views on Aging as a Risk

    A foundational aspect of Sinclair's perspective on anti-aging research and intervention is the view of aging itself as a significant risk. He often discusses how society tends to underestimate the risks associated with aging, failing to treat it with as much urgency as other health issues. For Sinclair, the ultimate goal of anti-aging research isn't just to prolong life but to mitigate the myriad risks associated with aging, which he quips is "known to cause death" and is a condition that "runs in families," using humor to underline the universal nature of aging.

    Supplement Protocol

    In his book Lifespan: Why We Age – and Why We Don't Have To, he disclosed in 2019 that he is taking daily NMN, resveratrol, metformin, aspirin, vitamin D3 and vitamin K2. In the meanwhile, he has added several other compound to this protocol like Spermidine, Quercetin, Alpha Lipoic Acid (ALA), etc.

    ⇒ see Dr. David Sinclair's Supplement Protocol for a full list of supplements.

    Videos

    Produced by David Sinclair

    Podcasts

    Longevity Lifestyle Series with Serena Poon

    In August 2022 David Sinclair and Serena Poon startet the Optimize Longevity YouTube Channel that is all about tips for improving the quality of life and extending the lifespan.

    Season 1

    Season 2

    Season 3

    Interviews and Talks

    See also

    References

    1. ↑ 2021-12-27 - Interview Dr. David Sinclair - Huberman Lab Podcast - The Biology of Slowing & Reversing Aging
    2. ↑ 2022-12-29 - Interview Dr. David Sinclair - Moonshots with Peter Diamandis - Age Reversal Breakthroughs, FDA Approval, and Living Forever
    Retrieved from "https://www.longewiki.com/w139/index.php?title=Dr._David_Sinclair&oldid=2383"