Model Organisms: Difference between revisions

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    Revision as of 03:28, 8 December 2023

    Model organisms are non-human species that are extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the organism model will provide insight into the workings of other organisms. In longevity research, model organisms are crucial for understanding the mechanisms of aging and developing interventions to extend lifespan and improve healthspan.

    Importance in Longevity Research

    Model organisms offer several advantages in longevity research:

    • Genetic Manipulation: Easy to genetically manipulate, allowing researchers to study the effects of specific genes on aging.
    • Short Lifespan: Many have short lifespans, enabling the study of genetic and environmental impacts on aging within a reasonable timeframe.
    • Conserved Pathways: They often share many biological pathways with humans, making it possible to translate findings into human aging research.

    Common Model Organisms

    Organism Scientific Name Lifespan Use in Research
    Yeasts Saccharomyces cerevisiae Days Studying cellular aging, replication, and metabolism
    Nematodes Caenorhabditis elegans 2-3 weeks Genetic and pharmacological studies in aging
    Fruit Flies Drosophila melanogaster 40-50 days Genetic regulation of aging and age-related diseases
    Mice Mus musculus 1-2 years Aging and age-associated diseases research, genetic similarity to humans
    Zebrafishes Danio rerio 3-5 years Vertebrate development and genetics, including aging processes
    Rhesus Monkeys Macaca mulatta Up to 40 years Studies relevant for human aging due to close genetic relation
    Rats Rattus norvegicus 2-3 years Used in a variety of aging studies, including age-related diseases and neurobiology

    See Also

    References