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    ===Resveratrol with Piperine===
    ===Resveratrol with Piperine===
    In 2021 [[Randomized Controlled Trial]], participants receive a single dose of resveratrol 2500 mg, with piperine in 0 mg, 5 mg or 25 mg dose. Despite the observation of piperine coadministration significantly increasing bioavailability ([[Cmax|C<sub>max</sub>]] and [[AUC|AUC)]] of resveratrol in [[C57BL/6 mice|C57BL]] mice, no significant increase in resveratrol or decrease in resveratrol glucuronide could be observed in healthy adults taking 2500 gm of resveratrol with piperine (5 or 25 mg) as compared to resveratrol alone. {{#pmid:32868637|pmid32868637}}
    In 2021 [[Randomized Controlled Trial]], participants receive a single dose of resveratrol 2500 mg, with piperine in 0 mg, 5 mg or 25 mg dose. Despite the observation of piperine coadministration significantly increasing bioavailability ([[Cmax|C<sub>max</sub>]] and [[AUC|AUC)]] of resveratrol in [[C57BL/6 mice|C57BL]] mice, no significant increase in resveratrol or decrease in resveratrol glucuronide could be observed in healthy adults taking 2500 gm of resveratrol with piperine (5 or 25 mg) as compared to resveratrol alone. {{pmid|32868637}}

    Latest revision as of 03:54, 11 February 2024

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    Message definition (Resveratrol)
    ===Resveratrol with Piperine===
    In 2021 [[Randomized Controlled Trial]], participants receive a single dose of resveratrol 2500 mg, with piperine in 0 mg, 5 mg or 25 mg dose. Despite the observation of piperine coadministration significantly increasing bioavailability ([[Cmax|C<sub>max</sub>]] and [[AUC|AUC)]] of resveratrol in [[C57BL/6 mice|C57BL]] mice, no significant increase in resveratrol or decrease in resveratrol glucuronide could be observed in healthy adults taking 2500 gm of resveratrol with piperine (5 or 25 mg) as compared to resveratrol alone. {{pmid|32868637}}

    Resveratrol with Piperine

    In 2021 Randomized Controlled Trial, participants receive a single dose of resveratrol 2500 mg, with piperine in 0 mg, 5 mg or 25 mg dose. Despite the observation of piperine coadministration significantly increasing bioavailability (Cmax and AUC) of resveratrol in C57BL mice, no significant increase in resveratrol or decrease in resveratrol glucuronide could be observed in healthy adults taking 2500 gm of resveratrol with piperine (5 or 25 mg) as compared to resveratrol alone. [1]

    1. Bailey HH et al.: A randomized, double-blind, dose-ranging, pilot trial of piperine with resveratrol on the effects on serum levels of resveratrol. Eur J Cancer Prev 2021. (PMID 32868637) [PubMed] [DOI] [Full text]