Dr. David Sinclair's Supplement Protocol

This article presents a comprehensive list of substances used by Dr. David Sinclair, a leading figure in aging and longevity research. The information was collected from official videos featuring Dr. Sinclair, where he discusses his personal regimen and the reasoning behind it.

For anyone interested in the specifics of what Dr. Sinclair has said, each video mentioned in this article is accompanied by a link. These links direct you to the full transcripts of the interviews, allowing readers to easily search and verify his statements. This way, you can read exactly what Dr. Sinclair said about each substance, ensuring accuracy and understanding of his recommendations.

It's important to remember that while Dr. Sinclair shares his personal choices, these are based on his own research and health status. Everyone is different, and what works for one person might not work for another. Always talk to a healthcare provider before starting any new health regimen.

Enjoy discovering more about these substances and Dr. Sinclair's insights into longevity!

Protocol

Substance	Dose	When	Comment
Nicotinamide Mononucleotide (NMN)	1000 mg	Morning
Resveratrol	1000 mg	Morning	Started taking it in his early 30s
Metformin	800 mg	Night, not when he making excercise the next day and muscles are growing
Spermidine	1000 mg	Morning
Quercetin	500 mg	Morning	In Dr. Sinclair mentoined that he took quercetin and fisetin around Jan 2022 for one month.
Fisetin	500 mg	Morning
Vitamin D3	4,000 to 5,000 IUs
Vitamin K2	180 to 360 mcg
Vitamin Bs (B3, B6, B12)	Variable		Monitors Vitamin B levels with Inside Tracker because you want not too much and not too low
Low-Dose Aspirin	83 mg	Night
Trimethylglycine (TMG)	500 - 1000 mg		In a 2019 interview , Dr. Sinclair mentioned that he takes TMG as a precautionary measure, suggesting that excessive NMN supplementation might deplete the body's available methyl groups. However, only audio files of this interview remain, as the YouTube video was deleted. Notably, he hasn't mentioned TMG in any subsequent podcasts or videos, leading to the assumption that Dr. Sinclair might no longer be taking TMG.
Alpha Lipoic Acid (ALA)		Night
Selenium			By eating Brazil nuts
Satin			Takes Satin since he was 29 because his cholesterol was way up (beyond 300) and his grandmother had a stroke in her 30s.
Coenzyme Q10 (coQ10)		Night	coQ10 is to make sure that the Satin doesn't deplete that too much
Omega 3-6-9 (fish oil)
Taurine	2000 mg

Mentioned in Videos

X = Taking, M = Taking in the morning, N = Taking at night, T = Taking temporarily

		NMN	Reseratrol	Metformin	Berberine	Spermidine	Quercetin	Fisetin	Vitamin D3	Vitamin K2	Vitamin Bs	Low-Dose Aspirin	TMG	ALA	Statin	coQ10	Omega 3-6-9	Selenium	Magnesium	GABA	L-Theanin	Taurine
Lifespan: Why We Age – and Why We Don’t Have To	Sept. 2019	X	X	X					X	X		X
2021-12-27 - Interview Dr. David Sinclair - Huberman Lab Podcast - The Biology of Slowing & Reversing Aging	Dec 2021	X	X	M
2022-01-26 - Podcast Dr. David Sinclair - NMN, NR, Resveratrol, Metformin & Other Longevity Molecules	Jan 2022	X	X	N		X	X	X
2022-08-30 - Interview Dr. David Sinclair - Optimize Longevity - What To Eat & When For Longevity	Aug 2022	X	X	X					X	X	X	N		N	X	N	X	X
2022-08-31 - Interview Dr. David Sinclair - Optimize Longevity - Longevity Molecules and Supplements	Aug 2022	X	X	X		X	T	T
2022-09-02 - Interview Dr. David Sinclair - Optimize Longevity - Keeping Your Brain Young	Sep 2022													X		X	X		N	N	N
2023-07-17 - Interview Dr. David Sinclair - Optimize Longevity - Build Muscle & Maintain Longevity	Jul 2023			N	X																	X