Fasting-Mimicking Diet: Difference between revisions

    From Longevity Wiki
    No edit summary
    Line 3: Line 3:
    ==Todo==
    ==Todo==


    *https://www.telegraph.co.uk/news/2024/02/20/following-a-fasting-like-diet-five-days-a-month-reverses-bi/
    *{{pmid text|38378685}}


    ==References==
    ==References==

    Revision as of 12:24, 21 February 2024

       This article is a stub. You can help by expanding it.
    

    Todo

    • 2024, Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk [1]

    References

    1. Brandhorst S et al.: Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk. Nat Commun 2024. (PMID 38378685) [PubMed] [DOI] [Full text] In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing damaged cells including cancer and autoimmune cells, reduce inflammation, promote multi-system regeneration, and extend longevity. Here, we performed secondary and exploratory analysis of blood samples from a randomized clinical trial (NCT02158897) and show that 3 FMD cycles in adult study participants are associated with reduced insulin resistance and other pre-diabetes markers, lower hepatic fat (as determined by magnetic resonance imaging) and increased lymphoid to myeloid ratio: an indicator of immune system age. Based on a validated measure of biological age predictive of morbidity and mortality, 3 FMD cycles were associated with a decrease of 2.5 years in median biological age, independent of weight loss. Nearly identical findings resulted from  a second clinical study (NCT04150159). Together these results provide initial support for beneficial effects of the FMD on multiple cardiometabolic risk factors and biomarkers of biological age.