Longevity Wiki

2023-08-24 - Interview Dr. David Sinclair - Moonshots with Peter Diamandis - Aging is Now Optional (Abundance360)

Revision as of 03:12, 12 September 2023 by Strimo (talk | contribs)
  • In this episode, filmed during Abundance360, Peter and David discuss David’s groundbreaking research on reversing aging through epigenetic changes, emphasizing that aging is not just damage to the body but a loss of information. They talk about age reversal as a possibility, rejuvenating brains, and regaining lost memories.

Transcript

do you think there is an upper limit to

human aging it's not even a question

explain

[Music]

I thought that that wasn't fair to have

Consciousness and to know that we're

going to be sick and die and watch

everyone else died I was inspired by my

grandmother who told me that humans can

do better my PhD supervisor said why

would you go study aging it's not even a

real science and thank goodness I didn't

listen to him aging isn't just damage to

the body like we wear out it's actually

a loss of information there will be a

day I believe where you'll be able to

rejuvenate your brain and get back

memories get your ability to learn again

I'm no longer talking about slowing

aging I'm talking about true age

reversal multiple times there's a backup

copy of information in every cell and

that fact that there was a backup copy

changes everything there is no law that

says we must age remember that

foreign

[Music]

welcome to moonshots and mindsets one of

my favorite conversations from abundance

360 this year was a fireside chat with

Dr David Sinclair knowing around the

world as one of the leading if not the

leading thinker on age reversal and

epigenetics David is a professor at

Harvard Medical School who studies aging

and Longevity he had just published a

epic paper in cell about the work he's

done over 13 years on how to accelerate

aging from epigenetic changes and then

reverse that aging in this segment we're

going to be diving into the work that

he's most recently done and where he

thinks it's going

you know uh I'm a fan of David a big fan

I've donated to his lab I've written

about his work in the book that I wrote

with Tony Robbins called uh life force I

promoted his book lifespan David

Sinclair's book uh probably more than

I've promoted my books he's one of the

most exhilarating thinkers a dear and

Beautiful Soul we're going to be

visiting David during my longevity

Platinum trip this coming August and

going to his lab and I'll probably have

a follow-on podcast when we dive into

some of the deep science that he's doing

he's an individual that during this

conversation will answer the question is

there an upper age to how long we live

what is the latest on the epigenetic

reprogramming that has been able to

reverse the aging of tissues and he's

someone with whom I'm working on a

health span X prize super excited about

this all right so settle in get ready

what would you do with an extra 20 or 30

years of a healthy lifespan

you're about to find out enjoy this

episode from my private Summit abundance

360 with Dr David Sinclair welcome David

thanks Peter thanks for having me back

hi everyone

um uh thank you to you and Serena for

flying in from India it was a long

flight how long was that

I don't know

too long

uh well uh the topic of longevity has

grown to uh one of Epic Proportions

um and I think I want to hit on the

point I made earlier uh the idea of

human health span extension of age

reversal was kind of a taboo subject a

while ago wasn't it

well not too long ago yeah when I

started in this field in the early 90s

it was considered the end of my career

by many people so my PhD supervisor said

why would you go study aging it's too

complicated to understand it's not even

a real science and thank goodness I

didn't listen to him yeah

so remember that for our students out

there watching

was it what what was it that got you

um to move into that direction was it a

personal passion was it an Inkling

I was definitely more than an inkling

and still is uh if any of you have read

my book you'll know that it was um by

the way how many folks up here have read

lifespan yes thank you I appreciate that

um

and Peter I think you know the answer to

the question that's why you asked it I

uh

I was inspired by my grandmother who

told me that humans can do better and

that's what I love about what Peter does

here it's that's the vision it's that we

can always do better there's a Bright

Horizon that we need to get to we need

to steer Humanity in that direction

um I felt that way my whole life that's

why we're friends uh among other reasons

and uh so she said when I was four years

old that everybody I knew in including

my pets uh were gonna die and it's not

going to be pretty

um and then I'm gonna die and as a

four-year-old that was a bit of a shock

to be told that and we all we all learn

this around the same age but we forget

about it because it's too painful to

live every day knowing that fact as

sentient beings as conscious animals

it's really a burden that we we bear

and I also I thought that that wasn't

fair to have Consciousness and to know

that we're going to be sick and die and

watch everyone else die

that was the age four and then at age

around 15 16 I thought this new

technology called genetic engineering

could actually tackle this problem in a

way that had never been done before so I

set my sights on that

let's go to uh January 12th uh you

published a paper and sell you published

a few Landmark papers this one being

amongst them

that showed

the ability to control aging using

epigenetics in mammals

just you know what were the major points

of that paper because it definitely it

cemented your your work and this this

concept of the information a Theory of

Aging

yeah so the information Theory of Aging

as it's called

um I formulated when I was still in my

20s I woke up in the middle of the night

with this idea it I guess it was

delivered to me by Muse's I wrote it

down in in my notebook and I still have

that notebook in my office and I've been

going off that Playbook ever since and

that's the idea that aging isn't just

damage to the body like we wear out it's

actually a loss of information that we

inherited uh from our parents and built

on during development

and ye cells have that problem and we

just finally published when was that 25

years later that we mammals have the

same issue and by understanding I think

a large part of why we age we're able to

control the aging process in a colony of

mice driving them forwards and backwards

in their age and making them get

diseases

um and now we're even reversing those

that's spectacular so one of the

questions we asked everybody when they

walked in here was to put on their badge

how old do you think you will live

and uh you know I think the 90 had had

120 or higher but I think what's

happened to society has trained us to

have certain expectations right you know

if your parents or grandparents had made

it to 75 or 80 you expect that and when

you hear the oldest living human being

is 122 123 you think okay there's a

brick wall there

um I one of the questions I'd love you

to share when the answer to let you

share is do you think there is an upper

limit to human aging

well I know there isn't you know there

is not yeah yeah it's not even a

question

drop the mic moment

let me explain

uh that there are lots of reasons why I

give that answer to me it's self-evident

but uh for some people it isn't and

there are critics of this idea that we

can live beyond 120 but one of the best

examples is

uh that we've been able to extend the

lifespan of every species that we've

tried to extend the lifespan of and

we're no different from those species

that's point one

um the second is that there are many

species who are very similar to us

genetically biologically that live a lot

longer than we do uh the best example

would be the bowhead whale but a lot of

whales live longer than us and that you

know they have children they're

conscious they produce milk so we just

need to mimic what they have that allows

them to live so long and I think we have

a much better idea now of how to do that

and so yeah that there is no law that

says we must age remember that

so one of the things that's going on

we've spent the last few days talking

about uh massive advances in Ai and

Quantum Computing and sensors networks

big data and the realization is we're in

a period of very hyper growth of these

Technologies and

um you know as Ray Kurzweil who will be

speaking tomorrow morning talks about

the bridge to a bridge that your job is

not to live

now to do something that's going to get

you an extra 100 years it's to get you

the next 10 healthy years to intercept

those Technologies do you agree with the

idea David I think you do but maybe your

time frame is different that this next

decade is very different than any time

ever

oh for sure

uh so we're already many decades ahead

of where I thought we would be

technologically

um from when I started I thought I was

working to help my children and future

children and uh and grandchildren but it

turns out that the pace of Discovery has

gone way faster and that's partly due to

technology we can now do an experiment

that analyzes billions of genes in the

same time frame

in a day that used to take us years of

work and billions of dollars and that

allows us to do very quick experiments

the other thing that makes me super

positive about this is that we've made a

I think we've made a major breakthrough

in our understanding of not just why we

age but also how to control that process

and the the turning point in my career

was the discovery that there's a backup

copy of information in every cell in

every everybody's cells

um and that that backup copy can be

accessed and there's a switch that you

can flip that allows cells to reset

their biological age and function again

as though they were young because

literally they are young again and that

fact that there is a backup copy changes

everything

we're no longer I'm no longer talking

about slowing aging I'm talking about

true age reversal multiple times and I

don't get laughed off stage anymore when

I say that

you want to give it up for that

I mean the idea

that we we aren't uh

tied to the tyranny of

aging and death is extraordinary it

changes everything everybody Peter

demand is here uh I've been asked over

and over again what do I do for my own

health well I put it down in this book

called Peter's longevity practices uh

it's very readable in just an hour in

the book I cover longevity diet exercise

sleep my annual found upload meds and

supplements longevity mindset it's

literally consumable in just an hour's

time hopefully to incentivize you to

make a difference in your life to

intercept the Technologies coming our

way if you want this it's free just

check out the link below and download it

right now the evidence that you have for

this backup copy there are a few things

you speak about in your book and your

podcast could you speak just a few

examples there

right let's see we've got some visuals

we could call up actually

so let's call up the the slide with the

the four faces on it the top right on

our guide here

slide six I think it is yep that's a

good one all right so uh let's do a show

of hands uh so how many of you have

heard of

the epigenome or at least epigenetics

hopefully everybody's raising your hands

okay

all right we're done

they're all good students all right so

the the concept is that what we've

realized is that most of disease and

disability is not driven by our genes

it's actually controlled by the

regulator of those genes which is the

epigenome one of the best examples of

that

um are these people here so these are

um individuals from two sets of twins

these are in Denmark a very large study

of Danish twins looking at the effects

of genes versus environment or

epigenetics which is what responds to

the environment

and so if we click the button forward

once you'll see that the identical twin

of these two individuals

uh hopefully you can see looks a lot

younger and is actually younger

biologically we can now measure that

and it turns out that by living a

healthy lifestyle

often you hear about doctors

recommending these things we know a lot

about how to slow down the aging process

you don't just look younger you actually

are biologically younger and that's why

if you exercise you eat right you eat

less often you take the right

supplements you will be biologically

younger and you will actually Stave off

disease until much later so what does

that actually mean if if we go back one

slide the concept is information so the

main type of information that we know

about is the genome in the DNA

but there's also another level of

information that's just as important and

even more complex that's the epigenome

and those are the structures that

control how the DNA is bundled and

shaped and which genes out of the 25 000

get turned on and off when we're forming

an embryo

um and we develop and those genes can be

switched on and off depending on how we

live if we put our bodies in a state of

perceived adversity or adversity that

isn't too damaging

the epigenome will actually respond and

be more stable

so the idea is you want to stabilize

your epigenome so that your cells

remember how to function youthfully for

longer the analogy as shown in this

slide is a compact disc hopefully all of

you remember what those things are

fairly incredible technology you could

fit about 20 songs on there

um when I teach at Harvard the kids are

like

what are you talking about this is so if

you're young it's like resetting a

computer or pressing the buttons on the

side of your iPhone uh so what the

analogy is that the digital information

is the is the DNA

um and that's the music but you need to

read it it's not just Pits on a on an

um a metallic disk the epigenome is the

equivalent of the reader of that

information and the songs of the of the

genes and aging I believe in our new

paper presents very strong evidence this

is the case that aging is the is akin to

scratches on the CD so that the cells

still have the music the genes but

they're just not read correctly at the

right time in the right place so that

your cells forget how to work so we see

that brain cells become more like skin

cells and skin cells become more like

kidney cells we become a melange instead

of Highly differentiated functioning

youthful cells and so that's the

information Theory of Aging and what we

found out in this paper is what drives

that process in large part is broken DNA

avoid x-rays CT scans if you can help it

don't fly too much if you can help it

yeah well don't do what I do and uh and

live with ways that actually prevent

those breaks because that disrupts the

epigenome we showed but here's the cool

point is that we've discovered you can

polish off those scratches and get back

the Beautiful music of cells and their

youth

so uh that's extraordinary there's a

concept that has been talked about for

some time of longevity escape velocity

that there's a moment in time that for

every year that you're alive science can

extend your life for more than a year

and I think the numbers that people talk

about today is that we're for every four

years we're adding a year of life

where are you on this and where do you

think what do you think will reach

longevity escape velocity

how far out are we

uh well so the

so we get about three months for every

year we stay alive currently without

breakthroughs like the one I'm talking

about

uh let me give you an update on where we

are today please and whatever you're

willing to say I know

some of it's amazing uh

the and we can extrapolate from here but

remember it's not linear there's one

thing you know from uh from this

conference

the the journey has been a rapid one we

made this discovery that you can reset

the age of cells human tissue Mouse

tissue

Living Mice

um

what is it now it's about five years ago

it was published three years ago

we started working on mice we reset the

eyeballs of mice to be young again they

got their Vision back that was the cover

cover that got the cover of nature uh

that's the December 2020. third row far

right slide uh yeah we were very

fortunate nature was bold enough to put

the title turning back time on the cover

of their magazine we're very honored by

that and this is the paper that changed

everything for my lab for my Outlook

about aging

and what we've done since then is we've

we've formed a company called life

biosciences and they've been pushing

ahead for all those years

we've done extensive studies in mice we

needed to know if it was safe it's it's

very safe we've never seen anything

negative after years of work and driving

this process we found that those three

genes O S and K for short

these are Gene Regulators that set off a

Cascade of events during embryogenesis

to make a young human

turns out lucky for all of us I think is

that those three genes also set back the

clock in adult cells without causing

tumors or any disease and without

bringing them back so far that yeah lost

identity and and this is the thing that

that blows my mind is you'd think that

if you just keep it on for a long time

you'd go back to zero age zero which you

don't want it's not true they go cells

go back about 80 and stop there's a

barrier that prevents them from going

back to zero if we leave off that other

Gene it's a gift to humanity for sure

and uh so now we're at the point where

we're conducting at life biosciences

um a boston-based company uh non-human

primates these are green monkey studies

um I should say the reason that there's

an iris on this cover is that we show

that you could reverse blindness due to

glaucoma and also old age by resetting

the age of the retina back to Youth and

those mice got their full vision back

again so the think about this your body

if this is true the body is

looks old but it's actually it just

needs to be reset so I don't think of an

old person now as an old person I think

it's just a body that needs to be reset

polished

so this is a big deal because I mean one

of the critiques about uh the work that

you and other individuals in this field

have done is it's all done in mice you

know that's great but we're humans you

know mice get all the benefits but

but non-human primates is a big deal we

share 99.99 of our kinetic code with

them we do and then and uh so I've I've

had a sneak peek at the at the results

and I would say things look rather

promising at this point it's a big deal

guys it's a very big deal

I think

and so it's my prediction that uh we'll

be in the next 18 months or two years

testing our first

age reversal uh clinical trial in humans

um to cure blindness and those studies

are actually being planned right now and

the material to do that is being

manufactured

how are you guys feeling about your

longevity mindsets now

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thank you all right let's get back to

our episode you know we're going to be

thank you we're going to be visiting

your lab during the longevity Platinum

trip in in August and September

um how many graduate students do you

have there what's the setup that you

have that will be meeting

uh yeah I don't know if you had this

experience but every day I go into my

lab and I'm surprised how small it is

it's just

like Elon Musk says if you have

dedicated people who know really how to

make a difference and look forward

rather than today

they can achieve anything and so I've

got this small group of around 20

bright-eyed young PhD students and

postdocs who perform all this magic and

uh it's a pretty small lab it's about a

thousand square feet we do it all there

and uh yeah it's a

to me it's it's it's amazing to walk in

there and I never get tired of showing

people around because it's it's like

magic you go in and you see um actually

I think the next slide might be

interesting click to the right and what

you'll see is that we're now growing uh

human brains have any of you seen to

grow these organites probably many of

you have seen this so on the left we

have cerebral organoids grown from Human

tissue we can now I think we're the only

lab now that can make these brains get

really old we can make them 70 years old

within a matter of weeks now they they

develop dementia we can measure that

with these electrodes on the right we

grow them on these little electrodes and

then we can and we do we reverse the age

of those little organoids and they get

their thinking ability back whatever

that is we do see the Electoral activity

come back sometimes they grow little

eyes as well it's kind of cool amazing

uh but why why do we do that it's not

just cool it actually tells us that the

whole brain is reversible and we've

actually done this now in mice we

haven't published this so you've heard

it here first that we can reverse the

age of an old Mouse's brain so they have

dementia we spend three weeks reversing

the age of the brain we just give them

an intravenous injection of our therapy

turn it on for four weeks and those mice

have a young brain and they have their

ability to learn again so I imagine a

day where we will have an infusion

either in our eye or in our whole body

and we just take a drug to turn those

genes on we use doxycycline just your

antibiotic that's a trigger for those

the trigger we don't need an antibiotic

it's not used as an antibiotic it's a on

off switch but we can reset the body and

so

after the eye we're going to go after

hearing and dementia yes and there will

be a day I believe where you will be

able to rejuvenate your brain and get

back memories get your ability to learn

again wow okay let's give it up for that

I mean are you guys hearing the same

thing

I just want to jump up and down here I

mean so I listen I

I've asked recurs while I've asked

George church and now I'm asking you uh

this idea of a longevity

um escape velocity Target date let me

give you a couple of a couple of uh

decades and tell me you know as a

betting man under over within the next

decade in the second decade in the third

decade

uh do you mean escape velocity or this

thing so when will have the ability to

go and get a a mechanism that will allow

us to uh

basically age in place or age in Reverse

so that we're no longer you know if ever

you're alive we're extending our

lifespan for more than a year

well it's it's already here it's just

not available widely

um it's already here ladies and

gentlemen

at least if you're a mouse well so I'm

not I'm not talking about our therapy

that one is that's hardcore that's a

rocket versus the Wright brothers uh but

there there are Technologies now that

and and some published papers that are

talking about like rapamycin uh

rapamycin and combinations so great

faith he has done good work and

continues to do good work on uh

combinations of molecules that have age

reversal properties so I believe that

there are already molecules and drugs

that you can use to reset your age

somewhat not go back to being 30 years

old again if you're my age our ability

in my lab and presumably scientists

across the world if they're smart to use

AI to answer questions that that we were

not able to you know I I wake up and

post Serena my partner who's here with

me um knows that I read papers first

thing in the morning uh usually and uh

so that is a real tax on on my brain but

I can only cover 100 papers this morning

7 000 papers

published in the Medical Science every

day

yeah it so that alone the ability to

synthesize that every day would be great

and it we're doing that now but just

ability to ask AI how to

find the best molecules that can mimic

the osk gene therapy you can ask AI that

you can get decent answers so we are

going to have

exponentially

exponential increases in the pace of

this field so it's not just AI helping

us be superhuman it's also the funding

level the amount of money that has gone

into certain companies in this area

since we published that paper in nature

uh there's been investment

um

uh and Jeff Bezos the evolution I was

showing them some of the companies

earlier that are yeah capitalized and

the reason is perhaps to State the

obvious is that this is an area that's

no longer the Backwater of biology it

really it's pharmaceutical development

and those that capture that land will be

the dominant industry of this Century

amazing

um you know one of the points I remember

in discussion with you and George Church

was that

it's likely that a real Rejuvenation uh

therapeutic

will if it works for one tissue and

organ will work for the entire body

that's also lucky but it's true that's

what we find in animals now we haven't I

haven't injected myself yet I'm probably

not going to do that for a few years

but in in mice uh I'm shocked that what

works in the eye in the optic nerves the

nerve cells works in the epithelial

cells in the retina works in the outer

layer of cells on the retina works in

the kidney we just published the muscle

if it works in all those different cell

types I think it's a universal process

of biology to be able to be reset and uh

so that's why I'm not exaggerating when

I think a whole body reset is coming

amazing one of the things that we talk

about on the on the longevity Platinum

trips usually is this idea of Gene

therapies using these basically these

molecular robots the adeno-associated

viruses and where you can Target your

virus towards particular tissues

well that's what we do we have a

domesticated virus the aav which is

already used and approved by the FDA our

system is a little bit more advanced the

one that we co-developed with George

um and that is it's a two-part system

where you need both system with both

parts but it's also inducible so right

now as far as I'm aware nobody else is

developing a product for uh in the

clinic that is has an on off switch I

think that's important for two reasons

to make that happen even though it's

triply expensive can I just when you're

as you're setting this up you're saying

we're going to put these three genes

the osk genes in all the cells in your

body

but we're going to have to turn it on

otherwise it's inactive

it starts out off correct yeah yeah and

that's what we did in this paper in

nature and this new one in cell is that

we have Exquisite control over when

these genes come on

for safety reasons but also because we

now know in the mice at least you can

reset multiple times so that you'll have

this treatment your body will be filled

with these genes they'll be off and if

we get sick or if we get injured or if

we get too old we can take a course of

an antibiotic for a couple of months and

get reset every time or if we're in the

emergency room they give you an infusion

of Doxycycline on come these repair

genes your nose regrow your spine

regenerates Etc

amazing

amazing

um you know Tony and I were blessed to

be able to provide you you know to give

you gift you a quarter million dollar

donation for your lab

um

where are you what if you had a limited

funding which hopefully you will you

don't yet where would you be

experimenting where would you be going

next

yeah I would put a lot of effort in the

next generation of age reversal

Technologies right now it's a gene

therapy which means it's it's going to

be expensive and hard to uh fulfill our

dreams of changing Humanity that said

um

what we want to do is we want to turn

those Gene therapies into

a pill

and so you can take a course of a pill

and get the same effect

and that's it's actually easier to

distribute molecules than it is viruses

so

I would expand that group and Screen

millions of molecules for those ones

that in combination could be taken

either you could have a Cosmetic Company

you could have probably one of the

biggest pharmaceutical companies that's

an area I think is super important to

get ahead of hey everybody this is Peter

a quick break from the episode I'm a

firm believer that science and

technology and how entrepreneurs can

change the world is the only real news

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World by looking at the incredible

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how entrepreneurs are solving the

world's Grand challenges what the

breakthroughs are in longevity how

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Transforming Our World so twice a week I

put out a Blog one blog is looking at

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biotech increasing your health span the

other blog looks at exponential

Technologies AI 3D printing synthetic

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Technologies are transforming what you

as an entrepreneur can do if this is the

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more now back to the episode and one of

the questions that people ask you and me

all the time is is this just a treatment

for the wealthy and we saw the study

done by London School of Business Oxford

Harvard that reducing age one year in

the global population adds 38 trillion

dollars a global economy so it really is

an uplifting of humanity so uh

you think we will get as we get to

volume we will get to a point where this

is accessible affordable and made

available to everybody

or I'll die trying or yeah that's the

goal I'm really optimistic I I already

have some molecules in the lab that show

signs of age reversal

um But there again you know I want to

build a Concord real fast let's talk

about a few of the molecules people have

heard about where are we on nmn which

you speak about elegantly in lifespan

um and which has now entered uh some

interesting human clinical trials in

partnership with the with the military

yeah that's right so NAD uh again a show

of hands so I know where to pitch it and

everybody knows of NAD now and and heard

of nmn not M M's mmn uh great so most of

you and you if you've read my book you

certainly know so for those of you who

don't know very briefly NAD is a

molecule required for life it's one of

the most abundant molecules in our body

and we make less of it and Destroy more

of it as we get older and uh this is a

molecule behind me called nmn it's one

of us a small group of chemicals that we

make normally but but we can also eat we

can swallow we can inject that raise

those levels of NAD back to youthful

levels and we've published that this

molecule taken at a gram or two gram

levels in humans just swallowed every

day will double or triple your NAD

levels which is good because

that we once did so that's not just

important because we lack energy without

this molecule it's required for about

500 chemical reactions in the body

there's a second reason why NAD is

important there are enzymes in our body

that we've worked on my whole career

called sirtuins that don't protect the

body against aging unless they have NAD

and as your levels go down your body

doesn't fight aging as well and that's

one of the reasons you get older faster

as you get older right so we know our

parents our grandparents fall off a

cliff age-wise health-wise one of the

reasons is our NAD levels fall

exponentially so we can replenish that

we've got clinical studies now that show

that it's not just possible to raise NAD

levels but but when you do that you have

health improvements in humans these were

studies out of Harvard she'll end up

Basin is is the pi I should credit him I

was not involved

and so what they said was lowering of

cholesterol lowering your blood pressure

um looks a lot like we got in mice

improved endurance so we're starting to

to learn that what we saw in the mice

which was

and publish this but increased lifespan

improve uh Health less Frailty

protection from radiation which is why

we should take these molecules while

flying or taking an x-ray

um long story short we're starting to

see translation of what we discovered in

mice occur in humans and there are over

five or yeah I think we're starting our

sixth human clinical trial with a

version of nmn which is crystalline and

and stabilize now I hope that that gets

on the market because it does belong in

the hands of doctors

um sooner than later because I think

that it'll be used widely for many

diseases you might be wondering what are

these five clinical trials they're if I

can remember some of them uh kidney

failure uh during covert

um there's an endurance one from the

military

uh I get in trouble saying that a few

years ago on Joe Rogan but now they

publicize it so I'm okay telling you

this is the special forces are using it

to help measure increasing strength but

also increasing cognitive Focus during

periods of extreme activity right uh

it's also uh being used for

um uh what is it brain fog after surgery

yeah and uh and also in a cancer trial

so it's it's pretty Broad and I'm

optimistic at least one of those is

going to be successful again will the

gentleman Ed shulock who runs this will

be part of our longevity trip we'll be

seeing uh it's a Metro biosciences is

that company uh Metro biotech thank you

biotech yes so it is meeting with that

too we co-founded that company we both

put our money into build it and uh

and uh he's the chairman on the advice

chairman of that and it's been a long

study you know people have heard about

NAD now

we started this company about 11 years

ago so I've been at it for a while

finally now that we hope the FDA because

it's being considered as a potential

drug the FDA is looking to take it off

as a supplement and until that study

comes out is that where we are

well so yeah there's a lot of rumors

about that so here here are the facts so

nmn has not been taken off the market

um I don't think it will be

um they're pressed this president

president for that

um the company metrobiotech did start

clinical trials about six years ago with

nmn and according to the Food and Drug

the administration act uh if that

happens then

the FDA should not allow additional

permits to sell a supplement of the same

material now it's similar material it's

not

exactly the same but still the FDA came

down with a ruling saying that it falls

under that rule now I'm I want everybody

to have access to anything I I'm all for

health not not for profit as a primary

goal

um so I I'm hopeful that Enderman will

stay on the market

yeah I mean I know some people have

gotten angry because they think I

control that company I don't I'm not CEO

I'm not the chairman

um I wish that that was not the case and

uh I think I've said publicly I know

I've said publicly that I want everybody

to have access to that

uh let's hit on a few other quick things

uh rapamycin yeah are you taking it

uh on and off

um

yes I I'm taking six milligrams once a

week

um

metformin

yeah

daily when I remember when you remember

yes well Serena I'm sure is there to

help out when she can uh you've gone

vegan have you always been vegan no I

was uh

pseudo-mediterranean about two years ago

and which I thought was healthy red wine

cheese it was a great life but

unfortunately I I was losing my memory

uh and I I really wasn't that I mean I

was about

seven or eight years younger than my

actual age according to inside tracker a

testing company

um I met Serena poon who's here in the

audience who Peter's been referenced

I've been referencing she's a among

other things a nutritionist but also a

longevity expert and a lot of things I

don't know she does and one of those

things is what to eat

um so she turned me on to veganism now

I would say I'm a struggling vegan I

still have butter and milk occasionally

I'll occasionally have some alcohol but

I do try to be plant focused as much as

I can and I do it turns out I love plant

stuff I love hummus and baba ganoush and

all that stuff so I don't just eat

salads but what what surprised me when I

switched to listen to Serena is that I

measure myself in many ways as I think

you all know I went back another two

years in my biological age just in a

couple of months after switching to that

diet so I've been convinced now I think

there are a lot of people who say well I

gotta have my meat I've got my alcohol I

would say just try to temper it

especially the alcohol

yeah my my father used to say Metron

artist on everything in moderation talk

about mitochondria I mean the PowerHouse

uh you know the whole nmn NAD complex

but

um

the number of mitochondria fall off as

we age and the efficiency of them

um what's that's one of the Hallmarks of

Aging

yeah it is so there are about a dozen

Hallmarks now we keep adding on and

these are really underlying causes of

Aging mitochondrial dysfunction is one

of them

um though I think that epigenetic

changes drive a lot of these including

mitochondrial effects because when we

reset the age of the cell the

mitochondria get rejuvenated which is

good news now these power packs decline

in a man and boosters of NAD rejuvenate

mitochondria and that's we've been shown

to be highly beneficial in animals and

knowing people and so one of the things

that you want to do is make sure that

your battery packs your mitochondria

stay healthy and numerous and that's one

of the reasons exercise and fasting are

beneficial is that your body boosts the

mitochondria and your fasting regime

right now is it has it changed at all

are you still one meal a day or are you

I try I ate a little bit of lunch as you

saw I I really try it Serena will tell

you like pieces

yeah you know it's really hard I agree

that just having one meal a day

um is a challenge I think it's okay if

you're not perfect you I try to skip

breakfast I try to skip lunch I'm not

always successful but in general my

average day looks like most of my

calories are eaten within a six hour

window and so I feel getting enough

protein to keep your muscle mass we've

talked a lot about the importance of

muscle and reversing sarcopenia as we

age yeah

I do so I think if you if you don't pay

attention to what you eat and you just

eat lettuce leaves you're not going to

do it but we're Serene and I are very

careful we we focus on legumes and we we

those plants that have high protein

content and nutrition and that's the key

you need to educate yourself on what to

eat not just when to eat

uh I think I promoted uh lifespan more

than any of my own books it was just

such a beautiful book you're very kind

and I think it's important it's waking

people up to the possibility to give

them hope and to give them a mindset uh

you have another book you're working on

right when do we expect that what's it

going to be about

uh well also congrats on on your book

life force so it's sold very well and I

think deservedly so there's a whole

chapter in the book that Tony and I

wrote about

David yeah well thank you again for that

that was kind and if you haven't read

live for us well worth it uh so yeah the

book two is everything that you wanted

to know that wasn't in lifespan will be

in this one

uh so I'm thinking about calling it

lifespan too it's really a journey

through second life through time that's

a good one yeah a Journey Through Time

looking at what makes us human what what

are you know what's in our genetic

makeup and our epigenetic makeup

that we can learn from in how to live

our lives through this tumultuous time

where Society is trying to not just kill

us but make us age rapidly

um our lifestyles of sitting and eating

and lack of exercise stress even social

media is really bad

these are things that put the body in a

state of complacency and this book will

be in the same way lifespan was the

textbook this will be the guidebook of

how to live in today's world and Beyond

amazing

um you know you pinned a tweet in which

you talk about the factors that are

counter to

a longer healthier life smoking for sure

that's the worst and the worst alcohol

intake

again new new data data says alcohol is

worse than I even thought um so if you

want your Resveratrol take the pill not

the red wine definitely okay

waist size

what waste a waist size yeah so people

who are overweight

um have a in general an older epigenetic

age than those who stay at a BMI between

RC 21 and 24. so that's a fact so if you

want to age slower maintain your BMI in

what's considered a healthy range

inflammatory CRP levels

yep that's something that's yeah the

underlying killer for so much for sure

for sure and there are foods that you

eat can that can be inflammatory uh for

instance some of us are uh

have a reaction to dairy or to certain

grains be careful about that you don't

want that your gut is very important for

inflammation you don't want bacteria

getting into your gut lodging in your

bloodstream or in your brain that can

cause these diseases that we all know of

so yeah keep inflammation low and one of

the best ways to do that is to uh

not just eat well but also make sure

that you're not allergic to things in

your environment and you can do blood

tests to make sure that it's not

happening

David it's an honor to call you as a

friend

I'm grateful to have you here thank you

for all you're doing likewise sir thank

you sir let's give it up for David

Sinclair foreign

[Music]

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