2023-06-26 - Interview Dr. David Sinclair - The Longevity Experts - Why We Don't Have to Age & How to Fight Aging
- Length: 33:01
- Interviewee: Dr. David Sinclair
Transcript
Intro
| 0:00 | thank you [Music] |
| 0:26 | I've heard you say that there's no biological law that says we have to age which is which is a pretty radical |
| 0:33 | statement break that down for us a bit we tend to think that what we see is inevitable and it used to be the case |
| 0:39 | for the speed of humans on the planet we used to think that horseback was the fastest humans could |
| 0:46 | go we used to think that when you got an infection from a splinter that went gangrenous that was the end of that limb |
| 0:53 | or death we used to think that childbirth was always going to be potentially lethal uh these things we we |
| 1:00 | used to think were inevitable now we're in a world where I'm trying to let the world know that aging is no longer |
| 1:07 | inevitable um and in I'm a biologist I'm a geneticist at Harvard where I've been |
| 1:13 | studying this for close to 30 years now and there's been no evidence from my lab |
| 1:18 | or any lab around the world that has found evidence of any mechanism that tells us |
| 1:24 | that we must age there are processes that we've identified that happen over time but we found that those are highly |
| 1:30 | malleable we can slow them down and even in the last few years almost completely completely reset the system and reverse |
| 1:38 | aging and so I I challenge anyone to correct me when I say that aging is not |
| 1:45 | inevitable and also that there is a limit to human |
| 1:50 | lifespan where's the evidence for that there are plenty of species that live a lot longer than we do and genetically |
| 1:56 | they're not that different from us and with the technology that we have today like let's say we stop developing |
How long can we live
| 2:03 | technology today what do you think the upper limit is of how long people can live |
| 2:08 | well with today's technology uh if you have the means I actually think we're |
| 2:13 | pretty close to being able to prevent most cancers and heart disease and diabetes so those major killers are |
| 2:19 | already largely preventable and I'm including things like DNA tests for |
| 2:25 | cancer and MRI scans so yeah not everyone can afford those yet but shortly they hopefully will be able to |
| 2:32 | so if we stop technology right now I think that with a good diet and that knowledge and |
| 2:38 | lifestyle the average person could probably make it to 95. you know there are plenty |
| 2:43 | people who don't have the the knowledge or the means to do the right thing and that's one of the things that I'm doing |
| 2:49 | is education but I think that we're about to completely blow past human uh |
| 2:57 | longevity expectations and history of longevity so right now people who don't |
| 3:03 | look after themselves bring the average down there's covert there's drug addiction uh that brings the average |
| 3:08 | down across the planet especially in the US and so the average is almost 80 years |
| 3:13 | old here but those people who um look after their bodies from an early |
| 3:18 | age and do the right things and live long enough to to be able to reap the benefits of today's technology |
| 3:25 | um not even the future ones um can expect to live into their 90s my |
| 3:31 | father looked after himself late in life and he's now 84 and as healthy as he's ever been in his whole life so these are |
| 3:37 | the this is what people can expect now even with today's knowledge and technology and where do you think like where where |
The big breakthroughs
| 3:45 | you said we're kind of like at the point we're hitting some of these breakthroughs what are the big breakthroughs that have to happen to go |
| 3:52 | from let's say people living into their 90s to people living into their 150s |
| 3:58 | well they're happening in real time actually uh every week there's another breakthrough in aging research it's it |
| 4:04 | was a slow field when I started in yeast cells we were excited to make a yeast Cell live 30 longer that's 1995 |
| 4:11 | technology uh things are happening at a rapid Pace we've got the discovery that there's a |
| 4:16 | backup copy of Youth in every cell in the body that can be tapped into where curing my lab and companies that I've |
| 4:24 | started and others that are competing with mine or at least uh friendly competition uh are showing that that |
| 4:31 | it's not that difficult to reverse the age of an animal um we've done this in mice many times |
| 4:37 | now it's not that difficult a high school student could do it with the knowledge that we have now |
| 4:42 | um we're at the point where we're awaiting uh next week we'll announce results in monkeys for age reversal |
| 4:49 | we're curing blindness using this technology out of my lab so we you know I would say that the Wright brothers are |
| 4:56 | flying already do we have Commercial Air flight do we have a Concord yet no but |
| 5:01 | we know it's possible to fly so it's really not a question of of uh if anymore it's just a question of when |
| 5:07 | these Technologies become widely available so what's gonna what has to happen we need to figure out a safe way to |
| 5:13 | reprogram tissues in the body and eventually the whole body uh we already have done some clinical |
| 5:19 | trials in my companies we have positive human data that shows that we can slow down and reverse some aspects of Aging |
| 5:26 | biochemistry and the body can be reversed such as cholesterol levels blood pressure these are all doable with |
| 5:32 | today's technology out of my lab there's a new technology which is even better than that which is a little a little bit |
| 5:40 | behind that we haven't gone into humans but we are in monkeys as I mentioned that in the next two years will treat |
| 5:46 | our first patient it'll be uh to cure blindness |
| 5:52 | um and so you know the answer really is that I think we've already made a lot of the breakthroughs that can extend human |
| 5:58 | lifespan by decades um getting to 150 I don't think those breakthroughs are that far away given |
| 6:04 | how fast the field is going right now the investment in the billions of dollars into not just Labs but in |
| 6:11 | particular industry that has virgin just since our paper in 2020 showing that age |
| 6:17 | reversal is safe age reversal is possible so I'm I'm 49 and let's say relatively |
How long will I live
| 6:23 | healthy like what what what's a prediction and have have some money I can spend on some of these things what's |
| 6:30 | a prediction for the average person like me like how how long is somebody like me going to live do you think yeah I think |
| 6:37 | you need to throw away any uh preconceived ideas by looking at your parents and certainly your grandparents |
| 6:42 | uh we are going to live very different lives we're actually approaching a big inflection point for those who are alive |
| 6:47 | when these Technologies come on board in the next decade um so the point is if you know you're |
| 6:52 | young uh or but some people who are in their 70s 80s and 90s |
| 6:58 | you got to stick around do your best to live as healthy as possible seek the best medical care |
| 7:03 | uh get scanned if you if you want to detect cancer invest in your health is |
| 7:08 | the point you know you can invest in coffee every morning from a certain store down the road or you can invest |
| 7:14 | that same money and afford an MRI scan for cancer so stay alive for yourself at |
| 7:20 | your age uh things are going to happen rapidly by the time you're my age I'm now almost 54. uh the technology |
| 7:27 | hopefully will be here that you can be prescribed in medicine uh to not just |
| 7:32 | slow down aging but reverse parts of your body for for age Eyes Ears uh |
| 7:39 | probably other parts of the body and uh and certainly within our lifetimes we're |
| 7:44 | going to see a dramatic change not just in what we can do to the body which I believe is going to be reset multiple |
| 7:50 | times but the approach of medicine the approach right now of medicine and doctors around the world typically is |
| 7:56 | well come see me when you get old and sick and and then I'll treat you yeah |
| 8:01 | well that's waiting till the end stages of 8 aging cause problems we call them diseases but they're really the |
| 8:07 | manifestations of this process called Aging which we Now understand is a universal process across the body in the |
| 8:12 | same same process and different tissues that we call Alzheimer's and diabetes and heart disease these are all the end |
| 8:18 | products of this same process of information loss in the body which we call aging and uh those diseases are |
| 8:26 | currently tackled at the end of life we need to tackle them uh early and doctors |
| 8:31 | will have the attitude and it's happening right now thanks in part two people have read my book and |
| 8:37 | and the wave of longevity science they're looking at patients now some of the leading doctors and saying we can |
| 8:45 | treat aging itself we can start early we could take someone in their 40s and use |
| 8:50 | today's knowledge technology to prevent that process or at least prevent it um for another decade or two and when you |
| 8:57 | do that then what happens is you stay healthier for much longer and that's going to be a big shift as well it's not |
| 9:03 | just technology it's the approach of medicine as well and you mentioned these like things like getting MRI scans and |
MRI scans
| 9:09 | some of these other kind of like tasks to do early detection on things and one |
| 9:15 | of the and I I recently got a MRI scan which I thought was very very helpful full body MRI scan but I can imagine for |
| 9:22 | certain people um there's going to be a lot of false positives with these things and there's going to be other types of things to get |
| 9:29 | people to worry and the stress of some of these early detections may not outweigh like knowing about it like how |
| 9:36 | do you think about that or is it like hey okay if you happen to be a more neurotic person you have to work on that |
| 9:42 | first or how do you think about when you're when you're when you're advising friends to do these things |
| 9:48 | um yeah I think that that's a big mistake and I've heard a lot of people say that and particularly doctors |
| 9:54 | um I think that that's that's misguided for the following reason there are plenty of |
| 9:59 | tests that we do on pregnant women for children looking at the risk of say |
| 10:05 | having um a child with Down syndrome yep it's not proof but it's evidence that we |
| 10:10 | might want to follow up um same truth is true for these MRI scans |
| 10:15 | someone who's young uh like the two of us I regardless as relatively young we want to get a baseline reading of what |
| 10:22 | do we look like now and then compare that every year and see what changes it's the changes that are |
| 10:28 | important you don't go in necessarily like the Deltas every year every two years or something like that yeah and |
| 10:35 | it's no longer just a doctor looking comparing before and after there's AI systems already commercially available |
| 10:41 | that allow a machine to say oh that part of your body just changed in the last |
| 10:46 | year let's take a look at that or monitor it a little more closely maybe you want to come in for a scan every six |
| 10:52 | months to keep an eye on that you know it's not all about a waiting till you see a tumor it's about knowing how your |
| 10:59 | body's changing and getting ahead of that and it's not just cancer that you see with these scans you're looking at changes in your prostate size your gut |
| 11:05 | health your bone health your brain health your blood vessels all of these things are important to monitor changes |
| 11:11 | of and get ahead of it before it actually becomes a disease now I'm having Brian Johnson on the |
| 11:17 | podcast soon he's trying to spend a couple million dollars a year to reduce his biological age you're an avid |
| 11:24 | tracker of your own biomarkers do you have like an official kind of |
| 11:30 | figure for your own biological age and how does one even like determine that |
| 11:35 | well there are lots of ways um a very simple one is if you cross your legs and sit on the floor how easy is it for you |
| 11:41 | to stand up without touching the floor if you can do that you're you're doing well uh someone middle age typically has |
| 11:48 | to push themselves off with one hand and if you're in your 80s you might need to get onto one knee that's easy |
| 11:54 | um but that's not very accurate the real data comes from blood tests or cheek swabs what I've been doing for now a |
| 12:01 | dozen years is monitoring my blood work I don't do it that often I'm not like Brian where I'm doing uh you know lots |
| 12:07 | of different tests and taking lots of supplements but I do believe that without measuring anything you're Flying |
| 12:13 | Blind like driving a car without a dashboard nobody would do that uh who's saying |
| 12:18 | um and so take some blood tests there are some ways to do that you can ask your doctor or go to some of the commercially available |
| 12:24 | tracking sites I've been an investor and an advisor to inside tracker for many |
| 12:30 | years um and they've been looking at my blood work and they and I together developed an algorithm to estimate one's |
| 12:37 | biological age using that and according to that test I'm in the top two percent |
| 12:43 | of people of my age for youthfulness I'm about 10 years younger based on that than my actual age so I'm 43. there are |
| 12:50 | other tests there's DNA methylation tests I launched a company recently called Telehealth which is for testing |
| 12:56 | epigenetic age which is measuring your DNA uh chemical changes and so there are |
| 13:02 | a variety of ways there's no one test to rule them all I'd like to do those two kind of tests to give me an idea of how |
| 13:08 | I'm doing but most importantly it's about looking at the changes and see how you're doing and trying to correct those |
| 13:14 | errors or non-optimal numbers that can occur over time and you want to adjust things you want to be scientific about |
| 13:20 | it to me it comes naturally of course I'm a scientist um so you measure a change measure again |
| 13:26 | that's the the way to go about life I think and optimize your body and often |
| 13:31 | I'm asked you know tell me what to do Professor just tell me what pill should I take now there are some rough rules |
| 13:37 | but really everybody's different everyone has a different genetics different background different lifestyle |
| 13:42 | different history different parents different environment and so you need to monitor yourself but I agree you know |
| 13:49 | it's not easy to do what Brian does there's no way everyone can afford it let alone spend as much time on it but |
| 13:54 | for very little money you know investment like giving up a cup of coffee or the money that it would take |
| 14:01 | to have a Year's worth of those coffees you can spend that on your own health and you'll reap much greater Awards or |
| 14:07 | rewards than you'd get from drinking a cup of coffee and if you can afford it do both thank you |
Hot Cold
| 14:12 | yep now I I read your book lifespan I took extensive notes and actually changed a lot of my own behavior and |
| 14:19 | would love to dive into a couple things one things that you got into in the book was this kind of idea of hot cold |
| 14:26 | um and I I had a little trouble just following the science of that even though I now do it because it's fun |
| 14:32 | um why why is this kind of hot cold combination good yeah so the big breakthrough |
| 14:39 | um well one of the big breakthroughs in the field that I was fortunate to be part of in the 1990s was the discovery |
| 14:45 | of longevity genes and they exist in all life forms except viruses uh and uh and |
| 14:51 | viruses hijacked them to infect us so that's you know still important there but yeah these longevity genes exist in |
| 14:58 | yeast and plants that's also important plants that we eat have longevity |
| 15:03 | activating molecules uh but really the point is that these longevity genes we discovered in the early 2000s respond to |
| 15:10 | biological adversity sometimes we call it stress but I don't think stress is the right word because it invokes |
| 15:17 | psychological stress which is not what we're talking about we're talking about cells and tissues and organs |
| 15:22 | sensing that the food supply or the environment or having to run away from a |
| 15:29 | saber-toothed tiger or an invading Army is dangerous and without danger our |
| 15:34 | bodies are complacent we don't like to waste energy so we put our energy into building fat and uh and at the expense |
| 15:42 | of getting older um and and staying young so that the |
| 15:47 | problem really is that our society is built to make us feel comfortable and take away any perceived threats to our |
| 15:54 | survival we don't have to go hungry most of us we don't have to run if we don't want to even our suitcases have wheels |
| 16:00 | on them we go up elevators and our body says perfect great I don't need to put energy |
| 16:06 | into activating longevity genes and they don't and what we end up with is early |
| 16:12 | aging rapid aging diabetes heart disease as a result of the lifestyle that we have which is an abundance rather than |
| 16:19 | an adversity memetic as we call it as I like to call it and so hot and cold those are similar as exercise and |
| 16:27 | fasting are that they invoke this defense response adversity pneumatics |
| 16:32 | and so you can do that so it's really about just it's about the stress yeah um and it's a it's a very uh and and |
Fasting
| 16:39 | doing hot and cold or doing like interval trainings or or um you know doing some sort of |
| 16:45 | um some sort of fasting type of thing it's a very low risk way of of stressing |
| 16:51 | your body right well you can always overdo it if you stay in a sauna all day you're probably not going to reap the benefits |
| 16:57 | or if you freeze your body parts same with exercise you can overdo it and fasting of course if you don't eat for a |
| 17:04 | month it's probably not going to be good either so you know you can always go too far but the concept is called hormesis |
| 17:09 | which is what really doesn't kill you makes you live longer and and that's what I recommend people live by is that |
| 17:16 | don't listen to the marketing uh from companies that want you to eat as much |
| 17:21 | as possible and snack between meals listen to your body listen to me hopefully and others like me like you |
| 17:26 | know bars alive my good friend who say that you want to put your body in a state where it it feels like it's |
| 17:33 | working or feels like it needs something and food and exercise and hot and cold are the best examples of that |
Interval Training
| 17:43 | on the interval training side is it uh obviously the stress is probably a |
| 17:49 | really good thing what else is why what is the other big reasons for this kind of like interval workouts and why |
| 17:55 | they're better yeah well it's the shock to the system um most of what we've learned is that |
| 18:02 | you can you can eat as much as you want during one meal but then you you taper |
| 18:07 | it off during the day uh same with exercise you can sit around but but then |
| 18:13 | you want to put your body into a hypoxic state where you're panting and cannot carry out a conversation and it's mixing |
| 18:20 | it up it's it's the contrast between relaxation and the hormesis the the |
| 18:26 | adversity it's not so much the constant adversity which we know constant adversity is not as good as mixing it up |
| 18:32 | athletes know this uh people who train their brain know this um and it's it's |
| 18:38 | so that's the good news is you don't always have to be running on a treadmill slowly or walking to get the benefits |
| 18:44 | you can just push yourself hard for 15 minutes three times a week and get really great benefits same with heat |
| 18:50 | same with cold do it shock the body get out and do something else yeah one minute cold shower or whatever |
| 18:56 | just something crazy yeah you know I will freely admit that I'm pretty lazy I I try to be a role |
| 19:03 | model as best I can but um I often snack um because I'm stressed I often don't exercise in fact I rarely |
| 19:10 | exercise like I should um but I do know the science and I do think that um doing a little bit goes a long way |
Cured Meats
| 19:17 | now one thing you um on the diet side you you advised cured meats like cold |
| 19:22 | cuts and bacon like why is that oh well there's a lot of science about |
| 19:28 | uh nitrogenous uh compounds so those nitrates |
| 19:34 | um are damaging of to DNA and there are two problems with damaging your DNA one |
| 19:40 | is that it'll cause mutations to your genome which is the digital information in the body and that's a cancer type of |
| 19:46 | thing cancer is the main readout of that we used to think it was also aging but actually there's more and more research |
| 19:51 | saying that it's the other type of information in the body that's more important for aging which is the epigenome The Regulators of the the |
| 19:59 | genes um and that's what we are manipulating in my lab to control the aging process |
| 20:04 | forward and backwards and so when you take nitrogenous compounds what you're doing is breaking chromosomes |
| 20:09 | um and that we've shown leads to aging because the body has to react to fix that DNA and in doing so it eventually |
| 20:17 | loses the ability to regulate the DNA itself okay got it now you're you're a big fan |
NMN
| 20:24 | of nmn and before I read your book I had never even heard of nmn why why is that |
| 20:31 | good well now we're talking about research uh from my lab in the early 2000s we found |
| 20:36 | that the sirtuin longevity genes that we've my team and well I should say my mentors team Lenny guarante uh |
| 20:43 | discovered certain so let me tell you about sirtuins these are seven genes in our body some of us have better versions |
| 20:49 | than others and in general it's it's found that they protect the body against diseases ranging from um Alzheimer's to |
| 20:56 | diabetes now these genes are get Switched Off over time the the main role is to make enzymes |
| 21:02 | that tell the body how to survive during adversity so when you're exercising and dieting and in sauna they come on |
| 21:09 | protect the body but the problem is as we get older they become less active and one of the biggest problems is that for |
| 21:17 | their activity they require a a little molecule in the body a very abundant one |
| 21:22 | called NAD NAD is required for life it's involved in chemical reactions but it's |
| 21:28 | also used as a sensor for the body of adversity when we have no adversity we're eating a lot and |
| 21:34 | sitting around NAD levels go down that's true as we get older as well so a 50 year old has half |
| 21:40 | the levels of a 20 year old for NAD um and what we like to do is to boost the |
| 21:48 | levels of NAD back up to youthful levels and mimic exercise mimic dieting or even enhance those modalities now we've even |
| 21:56 | got um human clinical trial data I was mentioning one of my companies has done clinical trials already for the last few |
| 22:02 | years and by raising NAD levels we can actually improve human health and we hope that this will be a drug one day to |
| 22:08 | treat diseases ranging from kidney failure to even covid-19 survival |
| 22:15 | so what about nmn well nmn is a precursor that the body uses to make NAD and by ingesting nmn we've shown in |
| 22:22 | humans that you can raise your NAD Levels by about two to three-fold um and that's beneficial uh in humans |
| 22:29 | based on clinical studies um you know when I say I'm a fan you know I'm not selling the stuff a lot of |
| 22:34 | companies claim that I'm involved with uh selling it that's not true I spend |
| 22:40 | fair amount of legal fees on trying to stop that um but yeah any NAD boosters as they're |
| 22:47 | called seem to be really beneficial I take nmn um and I've been doing so for probably about eight to ten years and uh |
| 22:54 | so far so good I've only seen benefits some people ask about and so basically you're saying the goal is to increase |
Benefits
| 23:01 | your NAD um one way to do that is through exercise you know you can do that by |
| 23:07 | fasting sauna um but there's this other way to do it is to take this nmn |
| 23:13 | um essentially it's a softball elements and you and and that can also boost your NAD |
| 23:19 | uh yes that's what the science is saying and others have shown to improve six minute walk so it's being used for |
| 23:25 | performance uh endurance and overall health it's not proving that it extends |
| 23:30 | lifespan in fact we've only just recently found it extensor mouse's lifespan and haven't published that yet |
| 23:35 | so it's early days we still have a lot to go on or to do at least but other |
| 23:41 | side effects for taking it or their um or does doing one thing make it |
| 23:47 | harder to do something else or it doesn't seem to be I mean mice in mice there's a couple of studies in some |
| 23:53 | rare cases of genetically inbred mice that don't have an immune system uh that |
| 23:59 | they there's hints that cancer might spread slightly more frequently in a very small |
| 24:05 | study but these are mice that are in bread and have no immune system so it's still full steam ahead with human |
| 24:12 | clinical trials there's been no Adverse Events in any of the patients that have been tested um or the subjects I should call them |
| 24:19 | um and yeah so I'm I'm not yet ready to say that there's any known uh or at |
| 24:24 | least uh tangible provable risks that uh you know I want to be the first person to know if there's a risk because yeah |
| 24:30 | football takes it my friends and family take it I take it um so I'm not I'm not selling it I just |
| 24:36 | want to know the science but I do know that my father is too old to wait till 100 proof that this extends lifespan you |
| 24:43 | and I are getting to that point where we can't wait um and so that's really what I'm doing is I'm educating the public about the |
| 24:50 | risks and rewards there are a couple of male studies that I want to point out but you know all weight up I think that |
| 24:58 | the risk right now for me and my family is it's worth taking that risk until |
| 25:03 | until further notice now you also take Metformin um and um and |
Metformin
| 25:12 | um like I don't even know how to pronounce it but sorry oh it was virtual where's virtual yeah yeah |
| 25:18 | um and you know uh and often I'll you know when I talk to my doctor he's like well I feel like you know maybe you're a |
| 25:25 | bit too young to take metformin and I mean yeah I I often encourage my patients who are let's say 60 or over |
| 25:31 | but it has some side effects and that it makes it a little bit less likely to build muscle mass and stuff like that |
| 25:37 | like how do you weigh some of those things uh well let's start with when should you |
| 25:42 | start um I had a a real um heart to heart with my doctor when I was 29. I had super high cholesterol |
| 25:49 | levels and he said I don't want to put you on a medicine because you're too young and I said dude |
| 25:56 | it I don't want to wait till I get heart disease to go on a medicine get put on me put it on put me on it now |
| 26:03 | so I've I've always been of the philosophy that it doesn't matter what age somebody is |
| 26:09 | you treat everybody the same way you know within reason of course 20 year olds are a bit young for this kind of stuff but if you're in your 30s and you |
| 26:16 | want to uh prevent heart disease prevent diabetes I think that it's perfectly |
| 26:23 | fine uh under Dr supervision taking medicines that will prevent disease especially when does these medicines are |
| 26:30 | extremely safe you do it under doctor Supervision in case there's a problem but with metformin for example and |
| 26:35 | certainly Resveratrol very very very rare that somebody uh gets so sick that |
| 26:41 | it's a problem and it's it's always reversible as well you just stop taking it if you get sick so these are risks I |
| 26:47 | think are worth taking I don't prescribe anything I don't even recommend anything publicly so I would say talk to your |
| 26:53 | doctor you know it's if they say you're too young I would keep fighting it I would show |
| 26:59 | you your data and if if you want there's always alternative doctors um I just I think that the the argument |
| 27:05 | that when you're young it's too early I you know there's a there's a at least I |
Building muscle mass
| 27:11 | heard that there's this trade-off of like okay it's hard to build muscle mass building muscle mass is very important |
| 27:16 | as you get older um and so um and so you know so you have to figure |
| 27:22 | the trade well it's frustrating to me as a scientist that |
| 27:28 | when somebody says something in public or someone a podcast just says it's a problem it becomes locked into the |
| 27:35 | Public's Consciousness and unfortunately nobody ever goes back and reads the actual paper that this |
| 27:41 | came from and that that was also true for the women's health initiative and breast cancer people still believe that |
| 27:48 | HRT causes breast cancer and uh that turns out it doesn't same for metformin |
| 27:53 | and exercise when you look at the data uh and it's really easy to see it's not |
| 27:58 | difficult you can look at it the graph that says there's a difference uh first of all is being manipulated in a way |
| 28:04 | that is deceiving they cut off the y-axis so that you're just seeing the very tippy top of the bars and the |
| 28:10 | actual difference is about five percent um and it turns out that that five percent is almost certainly due to |
| 28:18 | people just not doing the extra couple of reps in the exercise because they feel a bit more tired so what's the |
| 28:24 | solution well if you don't mind having muscles that are five percent smaller then no big deal those muscles |
| 28:31 | are just as strong and healthier um and have less inflammation I don't care if my muscles are still 95 |
| 28:38 | there I'm not trying to win any contests for a bodybuilding but I can also I can |
| 28:45 | avoid metformin on days I work out no big deal or force myself to do a couple more reps when I feel tired that's all |
| 28:51 | it is I wouldn't say that that's a reason not to take Metformin there are other reasons such as gastric uh |
| 28:57 | gastrointestinal issues that's more of a an issue but I think it the point here that I want to make is |
| 29:03 | make sure that the science is true and the data that you're getting is true don't just believe pundits or even uh |
| 29:09 | you know doctors who are saying this stuff try to go to the paper read it or listen to scientists who do read papers |
| 29:16 | and also just measure yourself do it under Dr supervision make sure that it's not harming you make sure you feel fine |
| 29:22 | and then by all means in my view it's worth starting in your 40s to maximize |
| 29:27 | your lifespan because we're aging every day it doesn't just begin after the age of 50 or 60. |
| 29:33 | now initially I was actually kind of skeptical to the idea that like big subsets of the population would adopt |
| 29:39 | any of these anti-aging Lifestyles but then I saw a couple of studies that say 10 of Americans are already intermittent |
| 29:46 | fasting every single day over 25 percent have already tried it maybe intermittent |
| 29:51 | fasting is is not the best one to measure because it's kind of easy to do you just kind of skip breakfast and so |
| 29:57 | it's kind of a simple relatively simple thing to do but how optimistic that you actually will see widespread Behavior |
| 30:04 | changes well we are in in the midst of a revolution in people's wellness and how |
| 30:12 | active they are in their own health pandemic was a major wake-up call to |
| 30:17 | people who stared in the mirror and saw their own mortality and then there was a boom in home testing because people |
| 30:24 | didn't want to go into doctor's offices for obvious reasons and so it's becoming also easier for people to take home |
| 30:30 | tests now we don't want people you know going rogue and testing themselves and |
| 30:36 | trying to interpret themselves with chat gpt4 and Beyond I don't think that's the |
| 30:41 | only solution I think there's a risk that we won't have enough doctor supervision and some people overdo it |
| 30:48 | there's always that risk so there's a caution here I do think though that there's a place for people taking their |
| 30:54 | own health into their own hands you can't always be supervised by your doctor when you're at a restaurant |
| 30:59 | people do need to realize that most of what affects their health in the future is up to them not their doctor and what |
| 31:06 | you do every day in your life Echoes for decades and that changing a lifestyle |
| 31:13 | is as important if not more important than the medicines you will take and that's why I think that this revolution |
| 31:19 | that we're seeing in the population not just in the US but around the world is a great thing and |
| 31:27 | will only become more prevalent and in 20 years it'll be the majority of people will will be on board with monitoring on |
| 31:35 | health it's going to get easier and easier with devices as well cheaper and cheaper and we'll look back at |
| 31:42 | two years ago when almost nobody did this and think that going to your doctor once a year for an annual checkup and |
| 31:48 | having the doctor bang in your knees and cough uh will will send medieval in fact even to us today it seems medieval |
| 31:56 | yeah it's in the intermittent fasting one it's while it's you know maybe uh 10 |
| 32:01 | of the population it seems like it's it's probably closer to 40 percent of my friends oh yeah and |
| 32:07 | um and one I think one of the reasons is well besides the fact that it's relatively easy to do |
| 32:13 | um it's maybe one of the easiest ones to to to to to do of of all the of all the things that people prescribe |
| 32:20 | um it's also also pretty easy to to at least for people to believe that has low |
| 32:26 | harm um and because if you say to somebody stop eating meat or something like that |
| 32:32 | first of all I think that's hard for people to do because they they love they might love their meat and second they may they may show you 40 studies of how |
| 32:39 | that actually could do harm to them um whereas and so uh so it's it's kind |
| 32:45 | of like this both things that come in of why people may change behaviors |
| 32:51 | yeah absolutely and everybody's different some people like hot and cold therapy some people don't um yeah sizes |
| 32:57 | for some it's not for me although I know it's important to do |