2022-12-29 - Interview Dr. David Sinclair - Moonshots with Peter Diamandis - Age Reversal Breakthroughs, FDA Approval, and Living Forever
- Length: 25:18
- Interviewee: Dr. David Sinclair
Transcript
Intro
| 0:00 | yeah we are kicking the can down the |
| 0:01 | road but that's the point you know life |
| 0:04 | is wonderful and the more times we kick |
| 0:06 | the can down the road the more life and |
| 0:09 | wonder we have and so yeah that's what |
| 0:11 | it is I don't think that we're going to |
| 0:13 | be able to Kick the Can down the road if |
| 0:16 | for in an infinite number of years based |
| 0:18 | on technology that I can foresee In Our |
| 0:21 | Lifetime now I could be wrong because I |
| 0:23 | didn't foresee reprogramming uh as |
| 0:26 | effective as it has become an age |
| 0:28 | reversal so I'd never say never but |
| 0:31 | given my viewpoint right now I think |
| 0:33 | that 150 is achievable in many of our |
| 0:36 | lifespans but not immortality |
| 0:39 | and a massive transformative purpose is |
| 0:42 | what you're telling the world it's like |
| 0:44 | this is who I am this is what I'm gonna |
| 0:46 | do this is the dent I'm gonna make in |
| 0:48 | the universe |
| 0:52 | hey everybody welcome back to another |
| 0:54 | episode of mindsets and moonshots uh my |
| 0:56 | name is Nick I'm Peter's producer and we |
| 0:58 | have today here Peter and David hey guys |
| 1:00 | how are you hey Nick hey Nick cool so uh |
| 1:03 | we have fielded hundreds of phenomenal |
| 1:06 | questions over the course of the past |
| 1:08 | day from both David and David and |
| 1:10 | Peter's Twitter and I'm going to be the |
| 1:13 | lucky one uh Fielding through them and |
| 1:14 | picking and popping so let's start off |
| 1:16 | with some fun ones |
Why Hasn't David Been On The Podcast Scene?
| 1:18 | uh David I'm going to direct this one at |
| 1:20 | you fans want to know why has David not |
| 1:23 | had a podcast since February ah |
| 1:27 | well I'm writing my second book |
| 1:30 | I'm editing a paper that's going to come |
| 1:33 | out in |
| 1:34 | a big Journal that's going to be high |
| 1:36 | impact uh and I'm working on making my |
| 1:40 | podcast even better uh better produced |
| 1:43 | and so trust me it's coming I know that |
| 1:48 | there's a lot of demand for it and I |
| 1:49 | thank everyone for their patience cool |
| 1:51 | that's a fair answer |
| 1:53 | um all right let's dive into one that we |
Where Are The Breakthroughs & When Are They Coming?
| 1:55 | had a bunch of and I'll read it verbatim |
| 1:59 | this one is from Tony and Megan they |
| 2:01 | asked and I'm going to ask it to both |
| 2:03 | Peter and David |
| 2:05 | um why is it taking so freaking long to |
| 2:08 | have meaningful longevity therapies come |
| 2:11 | to Market I feel like we're not making |
| 2:12 | any meaningful Headway and we're stuck |
| 2:14 | taking supplements that give us five to |
| 2:16 | ten years if we're lucky where are the |
| 2:18 | breakthroughs when are they coming well |
| 2:21 | some of them are already here uh in my |
| 2:24 | view we've got some drugs already |
| 2:26 | metformin rapamycin that I strongly |
| 2:29 | believe can slow down aspects of Aging |
| 2:32 | so we already have some technologies not |
| 2:35 | evenly distributed it's not available to |
| 2:37 | everybody because most doctors are |
| 2:39 | unaware or unwilling to prescribe these |
| 2:41 | medicines to people who are healthy |
| 2:44 | uh but the data looks good now what |
| 2:47 | about the new medicines that are in |
| 2:49 | development well one of them that I'm |
| 2:51 | developing actually a few of them at |
| 2:54 | Metro biotech are spin out from my lab |
| 2:56 | from 10 years ago is pretty Advanced |
| 2:58 | we're actually in in phase two studies |
| 3:00 | we've had some positive data we're |
| 3:02 | looking to publish now we've written up |
| 3:03 | the manuscript and so that is a a study |
| 3:08 | and a company that looks at NAD boosters |
| 3:10 | for pharmaceutical use for diseases of |
| 3:13 | aging and that one if all that all goes |
| 3:16 | well it's uh probably two to three years |
| 3:19 | away so that's uh that's the good news |
| 3:21 | also reprogramming of the eye to cure |
| 3:23 | blindness which we did in mice a couple |
| 3:25 | years ago we're in non-human primates |
| 3:27 | and that that could go into humans as |
| 3:30 | soon as next year |
| 3:32 | now the the question is why uh isn't it |
| 3:34 | quicker well it's because drugs are hard |
| 3:37 | super hard you know what industry can |
| 3:40 | spend 400 500 million dollars and still |
| 3:42 | fail not that many and that's what it's |
| 3:44 | like to develop drugs and there's a lot |
| 3:46 | of safety and efficacy that needs to go |
| 3:49 | into these products thanks to the |
| 3:51 | oversight of the FDA here in the US and |
| 3:53 | other countries under different auspices |
| 3:55 | and it's there's a high high hurdle |
| 3:58 | rightly so we don't want something that |
| 4:00 | doesn't work or can harm people getting |
| 4:03 | on the market but to get over that |
| 4:04 | hurdle takes time and a lot of money |
| 4:06 | that's a fair answer Peter I'd love your |
Peter's Thoughts On The FDA & The Future Of Medicine
| 4:08 | take and in your take I want to include |
| 4:10 | your opposing somewhat opposing thoughts |
| 4:12 | to David on how you feel about the fdm |
| 4:15 | bureaucracy well so listen the the |
| 4:18 | reality is what we're talking about is a |
| 4:22 | radical departure from traditional |
| 4:24 | medicine medicine has been you know you |
| 4:27 | go to we've all come to expect we go to |
| 4:29 | our doctor and we go for are once a year |
| 4:33 | physical if we're lucky and that doctor |
| 4:35 | will listen to your lungs your heart and |
| 4:37 | and it's expected you know old age is |
| 4:41 | something we come to expect and we don't |
| 4:44 | fight against it uh we expect it we try |
| 4:46 | and do a gentle Landing if you would uh |
| 4:49 | and the FDA is an organization built |
| 4:52 | around safety what I mean by that is |
| 4:55 | they will value the lives lost if they |
| 5:00 | approve a drug that kills people those |
| 5:01 | lives are much more valuable than all |
| 5:04 | the lives lost by not approving a drug |
| 5:07 | it's just the way it is today and so |
| 5:11 | until the science is Rock Solid |
| 5:16 | they're going to be hesitant to approve |
| 5:18 | something and it takes a huge amount of |
| 5:20 | capital Investments billions of dollars |
| 5:22 | and sometimes Decades of time |
| 5:26 | um |
| 5:27 | the reality is you know even this the |
| 5:30 | world of stem cells um stem cells are we |
| 5:33 | know that we exhaust our stem cell |
| 5:34 | population uh that when we're young we |
| 5:37 | have uh you know a hundred x a thousand |
| 5:40 | X number of stem cells in different uh |
| 5:42 | different pockets of the body from uh |
| 5:44 | from fat to muscle to neural stem cells |
| 5:48 | and they reduce and we can supplement |
| 5:50 | our stem cells |
| 5:52 | um and but today you have to go outside |
| 5:54 | the United States to do that because the |
| 5:56 | science isn't there to have proven its |
| 5:59 | efficacy and its safety yet and we're |
| 6:01 | going to get there but until it's you |
| 6:05 | know rock solid |
| 6:07 | um you're going to a different |
| 6:10 | jurisdiction to get those treatments it |
| 6:12 | takes time to be available what we saw I |
| 6:15 | remember I was in Richard Mulligan's lab |
| 6:18 | uh David back in in the 80s doing uh |
| 6:21 | early gene therapy work and gene therapy |
| 6:25 | was |
| 6:27 | was imagined back then to be an |
| 6:30 | extraordinary technology and it was but |
| 6:32 | when it was first applied to the first |
| 6:34 | patients it caused the death of a number |
| 6:36 | of children and it stopped the entire |
| 6:39 | field for decades |
| 6:41 | um so |
| 6:42 | people are cautious about taking |
| 6:44 | shortcuts David do you have any push |
David Sinclair's Experience Dealing With The FDA
| 6:46 | back there I mean you're interfacing |
| 6:48 | with the FD over the years is probably |
| 6:51 | more than most people will ever |
| 6:53 | experience in a lifetime given your |
| 6:54 | career are you friends and yeah I have |
| 6:57 | to find a way to word this so excuse the |
| 6:59 | way I'm wording it are you friends of |
| 7:01 | the FDA in the sense that you're happy |
| 7:03 | with how they work does it frustrate you |
| 7:04 | at times that they move slow uh are you |
| 7:08 | in alignment with Peter that there is a |
| 7:11 | increase or there should be an increase |
| 7:13 | in speed of how they approve things |
| 7:15 | coming up or what's your take well the |
| 7:17 | FDA was surprisingly receptive |
| 7:20 | um |
| 7:22 | to the idea that aging can be treated |
| 7:24 | with a medicine and they are still of |
| 7:27 | the opinion that if we can show that |
| 7:29 | aging is |
| 7:31 | uh slowable with with a treatment that |
| 7:33 | they would |
| 7:34 | strongly consider approving that |
| 7:37 | medicine for the treatment of aging and |
| 7:40 | I didn't realize that that was true but |
| 7:42 | what the individuals at the FDA the |
| 7:44 | human beings in this bureaucracy as it |
| 7:47 | is |
| 7:48 | um have to deal with a big organization |
| 7:51 | with lots of rules and procedures and |
| 7:54 | those rules dictate how quickly we can |
| 7:57 | move and their mandate is to protect the |
| 8:00 | public so that there's not as much |
| 8:02 | incentive to to get a drug on the market |
| 8:05 | as there is to protect them and that |
| 8:07 | does lead to this being rather a slow |
| 8:10 | process that's for sure now what I would |
| 8:13 | love is if there was increased public |
| 8:14 | opinion uh pressure |
| 8:18 | from all places from politicians from |
| 8:21 | Grassroots to increase the dialogue and |
| 8:26 | help the FDA find a way to make it |
| 8:29 | easier for us to get a drug on the |
| 8:31 | market that's based on Aging research |
| 8:33 | right now we cannot make a drug for |
| 8:36 | aging because aging isn't a medical |
| 8:38 | condition |
| 8:39 | if it were we'd have a lot more |
| 8:41 | investment and a lot more successful you |
| 8:45 | know David one thing I hope for in the |
| 8:47 | future is a right to try uh strategy |
| 8:51 | right in other words I always call it an |
| 8:53 | accredited patient program where if as a |
| 8:57 | patient as a subject I get permission |
| 9:00 | from my physician my husband my wife my |
| 9:03 | kids whatever that I want to try a |
| 9:06 | treatment that isn't FDA approved but |
| 9:08 | you know I've got this disease called |
| 9:10 | Aging and I want to try this even if |
| 9:13 | it's you know to be a subject |
| 9:15 | I think Reinventing How We Do now we do |
| 9:19 | have investigation new drugs and we do |
| 9:21 | have you know experimental protocols and |
| 9:23 | so forth but how do we we make it |
| 9:26 | um |
| 9:27 | more agile in that regard Peter I love |
| 9:30 | that idea that that you wouldn't be able |
| 9:32 | to just go online and order up if it's |
| 9:35 | an experimental drug right that's that's |
| 9:37 | too free because there could be |
| 9:38 | accidents |
| 9:40 | um and there's a maybe abuse of that |
| 9:41 | system for monetary reasons that said if |
| 9:44 | there were a certification whether it's |
| 9:47 | an MD or something an MD can can get |
| 9:49 | that would allow the use of experimental |
| 9:52 | drugs right now that is possible but |
| 9:55 | it's not widely used it's generally on |
| 9:58 | um if it was more widely available if |
| 10:01 | you have a terminal disease or something |
| 10:02 | that |
| 10:04 | um |
| 10:05 | doesn't have any current cure |
| 10:07 | why not try something that is at least |
| 10:09 | already shown in Phase One to be safe |
| 10:11 | yes exactly in fact uh David feigenbaum |
| 10:15 | I don't know if you know David he he's |
| 10:16 | uh uh he cured his or I didn't cure he's |
| 10:21 | treating his uh castleman's disease |
| 10:22 | using rapamycin and so they're you know |
| 10:26 | the numbers are interesting right there |
| 10:27 | are 3 000 FDA approved drugs and there |
| 10:30 | are 12 000 diseases and his work right |
| 10:33 | now is saying can we can we fund looking |
| 10:37 | at which of those 3 000 drugs might have |
| 10:40 | a dual use for the 9 000 diseases that |
| 10:43 | don't have a treatment right they've |
| 10:45 | already they're already on the market |
| 10:46 | they're already in production they're |
| 10:47 | already shown to be safe in in humans |
| 10:51 | um and so it's a rather than developing |
| 10:54 | a brand new treatment so his his efforts |
| 10:57 | called uh called uh every cure and it's |
| 11:01 | uh he just announced it at the Clinton |
| 11:03 | Global initiative a couple of weeks back |
| 11:05 | David and Peter what is your purse |
When Is The Right Time To Show Your Findings?
| 11:07 | personal preference to when you feel |
| 11:09 | comfortable enough to try something |
| 11:11 | David you probably have a lot of |
| 11:12 | exposure to this because you're |
| 11:13 | constantly testing things in the lab |
| 11:15 | when do you say okay you know what I'm |
| 11:17 | good enough to uh put myself on the line |
| 11:20 | here and Peter likewise I'd like to know |
| 11:22 | for you |
| 11:23 | uh I consider myself a chief guinea pig |
| 11:26 | for a lot of uh of what's out there uh |
| 11:30 | Tony Robbins who's a deer mutual friend |
| 11:33 | of both of ours and I think about that |
| 11:35 | all the time it's like huh interesting |
| 11:38 | so |
| 11:39 | um listen if it's |
| 11:41 | I'm probably not likely to be the first |
| 11:45 | human ever to take something but I will |
| 11:47 | be an early user of it let's leave it at |
| 11:50 | that yeah I'm the same I I I'm an |
| 11:53 | experimenter I'm assigned to stylist I |
| 11:56 | feel that if I'm going to be talking |
| 11:58 | about something I need to have |
| 12:00 | experienced it myself I would really |
| 12:02 | never talk about something unless I I |
| 12:05 | tried something and so I never recommend |
| 12:08 | anything I'm not even an MD I'm a PhD |
| 12:10 | but I will talk about my own experience |
| 12:13 | um in a way that will allow others to |
| 12:15 | think about it themselves |
| 12:17 | Sam yeah I think I think it's important |
| 12:20 | I think it's important uh as we're as we |
| 12:24 | are |
| 12:25 | speaking about this field and what's |
| 12:28 | becoming available uh to to explain |
| 12:31 | either that something I do do or the |
| 12:34 | reason I haven't right and actually a |
| 12:37 | New York Times article was written about |
| 12:39 | my lab and me and they said uh |
| 12:43 | um I think it was posed to the effect of |
| 12:46 | well David you're conflicted because |
| 12:49 | you're studying this molecule in the lab |
| 12:51 | and you're taking it you can be biased |
| 12:54 | and if there's something bad you'll hide |
| 12:56 | it and I'm I'm thinking to myself I want |
| 12:59 | to be the first person in the world to |
| 13:00 | know that there's something wrong with |
| 13:02 | this molecule because my father's taking |
| 13:04 | it I'm taking it and I will tell the |
| 13:06 | whole world to stop taking it if I see |
| 13:07 | something and I want to be that person |
| 13:09 | to find it ASAP so it's actually it's |
| 13:12 | it's flipped is that I'm looking for |
| 13:14 | problems with these treatments because |
| 13:17 | if I'm taking them or I tried them I |
| 13:19 | need to know if there's a problem and so |
| 13:21 | you know you can trust me that you'll |
| 13:24 | hear from me first if there is something |
| 13:25 | that's negative yeah uh I'm Ahmet |
| 13:28 | Foreman I've just started rapamycin five |
| 13:31 | milligrams my own body weight and I did |
| 13:33 | a lot of research and talked to a lot of |
| 13:35 | Physicians about it and felt that the |
| 13:37 | you know it's always a risk reward |
| 13:39 | situation and I just felt like at this |
| 13:43 | point the reward side was higher than |
| 13:46 | the risk well for sure and the older you |
| 13:48 | get |
| 13:49 | um the more so but we we tend to |
| 13:51 | underestimate the risk of Aging we don't |
| 13:53 | think about it as much as we should |
| 13:54 | aging is really really risky in fact we |
| 14:00 | it's no it's known to cause death yes it |
| 14:03 | runs in my family |
| 14:06 | David do you mind if I cut a night build |
Are We Doing It? Are We Going To Live Forever?
| 14:09 | off of that for a moment so one of the |
| 14:11 | questions that came in was uh let me |
| 14:13 | find it here |
| 14:15 | um it was uh are we effectively I'm |
| 14:20 | gonna shorten what they said but are we |
| 14:22 | effectively just kicking the can of |
| 14:24 | dying here and are we just prolonging it |
| 14:26 | say 120 500 years whatever the case may |
| 14:29 | be |
| 14:31 | um or or is the proposition that we're |
| 14:32 | going to live forever and |
| 14:35 | um what's your take and Peter what's |
| 14:36 | your take uh all right uh yeah we are |
| 14:39 | kicking the can down the road but that's |
| 14:40 | the point |
| 14:41 | life is wonderful and the more times we |
| 14:44 | keep the can down the road the more life |
| 14:46 | and wonder we have and so yeah that's |
| 14:50 | what it is I don't think that we're |
| 14:52 | going to be able to Kick the Can down |
| 14:54 | the road for in an infinite number of |
| 14:56 | years based on technology that I can |
| 14:59 | foresee In Our Lifetime now I could be |
| 15:02 | wrong because I didn't foresee |
| 15:03 | reprogramming uh as effective as it has |
| 15:06 | become an age reversal so Never Say |
| 15:08 | Never but given my viewpoint right now I |
| 15:12 | think that 150 is achievable in many of |
| 15:15 | our life spans but not immortality Peter |
| 15:18 | yeah so it most definitely kicking the |
| 15:20 | can down the road the analogy is and I I |
| 15:22 | was you know on a vacation with my |
| 15:24 | family and we're having so much a fun |
| 15:26 | time it's like let's stay an extra week |
| 15:28 | you know if if you're enjoying life uh |
| 15:31 | you know adding decades to it but let's |
| 15:34 | not forget we're in the steepest part of |
| 15:36 | the exponential curve uh you know in |
| 15:39 | terms of what's coming in Ai and |
| 15:42 | Robotics and Quantum computation that's |
| 15:44 | that's just on the edge of uh of our |
| 15:47 | capabilities so yeah I may not want this |
| 15:51 | Mortal body uh five you know not five |
| 15:55 | you know 50 years from now I may want a |
| 15:58 | upgraded body but the idea of being able |
| 16:01 | to see my grandchildren my |
| 16:03 | great-grandchildren to go to the moon go |
| 16:05 | to Mars to see what happens next |
| 16:09 | um is extraordinary I don't you know Ray |
| 16:13 | Carswell talks about the singularity |
| 16:15 | right the point at which the speed of |
| 16:17 | technological change is so rapid that |
| 16:20 | we're unable to predict what's next and |
| 16:23 | that number is Circa you know the early |
| 16:26 | 2040s let's not forget that's 20 years |
| 16:28 | from now I mean it's not like a hundred |
| 16:31 | years it's 20 years from now so uh part |
| 16:33 | of what we're talking about is |
| 16:35 | intercepting the technologies that will |
| 16:38 | give us longevity escape velocity but |
| 16:40 | beyond that the technologies that will |
| 16:42 | allow us |
| 16:43 | to connect our minds to the cloud maybe |
| 16:46 | it's uploading ourselves |
| 16:49 | um I'm not a huge fan of freezing myself |
| 16:51 | are you David |
| 16:53 | um yeah so I I definitely want to get |
| 16:56 | immortality or at least extreme |
| 16:58 | longevity is that a reason like an |
| 17:01 | awesome powers freezing yourself thing |
| 17:02 | yeah I know sure there's a lot of people |
| 17:04 | here yeah cryonics is the technology |
| 17:07 | it's the notion that if I freeze myself |
| 17:09 | and I don't rupture the cells and there |
| 17:11 | are ways to do that that hopefully |
| 17:13 | technology super advanced technology you |
| 17:16 | know a hundred or a thousand years from |
| 17:18 | now will be able to bring me back and |
| 17:19 | restate my neural structures and my |
| 17:21 | memories and so forth but that's that's |
| 17:24 | a subject for another conversation hold |
| 17:25 | on I have a question on this David uh |
| 17:27 | have you ever visited or Peter VA has |
| 17:30 | ever this is a very interesting question |
| 17:31 | visited a facility where people are |
| 17:34 | Frozen I mean is this a I I I thought |
| 17:36 | that this was all hearsay uh I have not |
| 17:39 | uh either have I but there are a number |
| 17:41 | of them and people I mean the first |
| 17:45 | person I just saw an article about this |
| 17:46 | the first person Frozen |
| 17:48 | uh was about 50 years ago and there are |
| 17:52 | companies today that you'll wear a |
| 17:55 | bracelet and |
| 17:57 | um at the moment of death uh when your |
| 18:00 | body when your your brain function |
| 18:02 | ceases they will come in and they'll |
| 18:05 | pull out your blood replace it with |
| 18:07 | effectively an antifreeze and uh and |
| 18:09 | freeze you and you can have the choice |
| 18:11 | of freezing your entire body or coughing |
| 18:14 | off your head and just freezing your |
| 18:15 | head because it takes less energy to do |
| 18:17 | that it may actually work |
| 18:20 | um I didn't think it would but actually |
| 18:22 | given that we can now reset the age of |
| 18:24 | cells I can imagine that you can quickly |
| 18:27 | unfreeze a person and get their cells to |
| 18:30 | begin the Rejuvenation process that we |
| 18:33 | seem to be able to control now |
| 18:34 | and uh yeah so I think it I wouldn't do |
| 18:37 | it myself at least currently uh but I |
| 18:40 | think that it's not as crazy as it once |
| 18:42 | seemed |
| 18:44 | um but I I would rather stay alive by |
| 18:46 | being alive and I think the Technologies |
| 18:49 | to do that are increasingly here it's |
| 18:52 | it's a it's a fun subject to think about |
| 18:54 | but I'd rather put my energy and focus |
| 18:56 | into extending the healthy human |
| 18:58 | lifespan you know what Peter and I are |
| 19:00 | very much into democratizing |
| 19:02 | Technologies and and cryonics is not |
| 19:05 | going to be for everybody it's a very |
| 19:07 | small few people number of people that |
| 19:09 | can afford this so that's again not a |
| 19:11 | good reason to focus our energies on |
| 19:13 | those kind of Technologies I have a lot |
How Are David & Peter Going To Reduce Aging?
| 19:16 | of deep appreciation for that answer I |
| 19:18 | have a great one I want to end it with |
| 19:19 | but uh Peter this one was directed at |
| 19:22 | you uh somebody wanted an update on I |
| 19:24 | didn't even know this was public yet the |
| 19:26 | age reversal prize and I'm not sure if |
| 19:28 | David you know about the age reversal |
| 19:30 | experts here has but obviously and let |
| 19:32 | me just cue this up for everybody |
| 19:33 | listening David efforts are |
| 19:35 | substantially documented realized and |
| 19:38 | and very public right now he he's in my |
| 19:40 | opinion the leading World expert on on |
| 19:42 | anti-aging at the moment and um you know |
| 19:45 | Peter I think that you're now going to |
| 19:46 | actively join this fight through one of |
| 19:48 | your efforts |
| 19:49 | um do you want to share how uh yeah sure |
| 19:51 | and David is is very much involved uh he |
| 19:55 | and George Church are uh are my |
| 19:58 | co-conspirators uh if I would our |
| 20:00 | scientific co-chairs of a 101 million |
| 20:04 | dollar age reversal X prize uh and the |
| 20:08 | question we've asked I mean we've been |
| 20:10 | talking about the idea is could we do |
| 20:12 | and it's not launched yet to be very |
| 20:14 | clear we're majority funded uh David and |
| 20:17 | I have been having a conversation every |
| 20:19 | uh every few days on the rule sets and |
| 20:22 | getting them really honed in I hope to |
| 20:25 | launch an early part of 2023 but uh we |
| 20:29 | talked early on about a longevity prize |
| 20:31 | but the problem with the longevity prize |
| 20:33 | like can you add 30 healthy years and |
| 20:34 | person's life which we will is you have |
| 20:38 | to wait 30 years to see if you have a |
| 20:39 | winner but can you in fact reverse aging |
| 20:43 | in someone in this case the rules we're |
| 20:45 | thinking about is can you give a |
| 20:48 | therapeutic that lasts for less than a |
| 20:50 | year but reverses biological age by 20 |
| 20:55 | years or more David do you want to add |
| 20:58 | your thoughts there yeah it the goal is |
| 21:01 | to inspire companies and Labs |
| 21:05 | individuals to work on methods to safely |
| 21:07 | reverse aging in multiple tissues and |
| 21:10 | organs to rejuvenate the body and make |
| 21:12 | it function better and uh and this kind |
| 21:15 | of prize money will be a huge incentive |
| 21:18 | um I think it's gonna have a big impact |
| 21:19 | on on the field and uh and drive |
| 21:23 | innovation in the same way other X |
| 21:25 | prizes have done so and so I'm super |
| 21:27 | happy to be involved we're looking at |
| 21:29 | you know we're trying to decide where |
| 21:31 | what the focus will be I I you know Dave |
| 21:34 | and I are honing in on on cognition on |
| 21:37 | muscle on skin on immune system I mean |
| 21:40 | these are the things that as you age you |
| 21:42 | want to look good you want to move well |
| 21:43 | you want to think clearly you want to |
| 21:45 | have able to have a good immunity in a |
| 21:47 | world of covet and influenza |
| 21:50 | um |
| 21:51 | but you know this is about getting the |
| 21:54 | smartest people on the planet to focus |
| 21:55 | on one of the biggest problems one of |
| 21:58 | the biggest Grand challenges on the |
| 22:00 | planet which is extending the healthy |
| 22:02 | Health span and David on a previous |
| 22:05 | episode you mentioned the economic |
| 22:08 | impact for adding one healthy year on a |
| 22:11 | person's life what was that number again |
| 22:12 | it was staggering well for the us alone |
| 22:14 | it's 86 trillion dollars in the long run |
| 22:17 | of doing that so so David uh where |
Where Can You Get To Know More About David Sinclair?
| 22:20 | should people go to find you |
| 22:22 | well I'm I'm active on social media |
| 22:25 | um so find updated news there |
| 22:28 | uh my podcast is still available and I'm |
| 22:31 | working on season two uh and that's on |
| 22:34 | all podcast Outlets uh my book I think a |
| 22:38 | lot of people got inspired by |
| 22:40 | um and I was inspired by yours too Peter |
| 22:43 | my book is called lifespan why we age |
| 22:45 | and why we don't have to and I didn't |
| 22:48 | get to talk a lot about what I do on my |
| 22:50 | in my daily life which supplements and |
| 22:52 | that kind of thing but that is outlined |
| 22:54 | in large part on page 304 of lifespan so |
| 22:59 | check that out that's the cheat sheet |
| 23:01 | but please do read the science as well |
| 23:02 | and all of the future that's coming so |
| 23:06 | that's where to find me um that is a |
| 23:08 | good spot other than that |
| 23:10 | um I'll be I'm working on it on a TV |
| 23:13 | show that uh I'll let you know how that |
| 23:17 | goes |
| 23:18 | show people the insides of our bodies |
| 23:21 | and how we work and how to improve our |
| 23:23 | bodies in our daily lives in a way that |
| 23:26 | no show has ever done before so stay |
| 23:29 | tuned for that too Nick do you have a |
| 23:30 | last question for us I do and I'm going |
The Human Side Of David Sinclair.
| 23:32 | to direct it at David and then Peter |
| 23:33 | will have you recorded on this too David |
| 23:36 | the the question that came in I thought |
| 23:38 | it was novel is uh are you happy if so |
| 23:40 | why and was there ever a point in your |
| 23:42 | life in which you weren't and what did |
| 23:44 | you do because uh I like this because a |
| 23:47 | lot of your research is pending on this |
| 23:49 | fulcrum of whether or not people can |
| 23:51 | resolve that okay uh am I always happy |
| 23:54 | uh no uh most days I'm happy because I'm |
| 23:58 | doing something that I dreamed of doing |
| 24:00 | and I'm fulfilled but I have down days I |
| 24:03 | have days where I get attacked by Lodge |
| 24:07 | farmer by colleagues I've learned to |
| 24:10 | have a thicker skin so I don't get |
| 24:12 | full-blown depression but it's still |
| 24:14 | it's still upsetting but I've learned to |
| 24:16 | trust in myself and be resilient and get |
| 24:19 | up um I find that having teenage kids is |
| 24:22 | the most challenging thing in life and I |
| 24:25 | have three of those and I'm still trying |
| 24:27 | to be a great dad uh so I'm a struggling |
| 24:30 | vegan and a struggling teenage guy |
| 24:33 | so that that's who I am outside of |
| 24:36 | research David thanks for being on the |
25:19 Outro
| 24:38 | show |
| 24:39 | um let us know what you think great |
| 24:40 | review and give us a follow find David |
| 24:42 | across all socials he's very active and |
| 24:45 | I think |
| 24:46 | um we're just really blessed to have had |
| 24:47 | him Peter do you want to share any |
| 24:49 | closing notes David it's a truly a |
| 24:52 | pleasure to call you a friend a |
| 24:53 | co-collaborator co-conspirator on this |
| 24:56 | journey we're ahead of uh and have a |
| 24:59 | beautiful day pal yeah you too it's |
| 25:01 | great to have you as a co-pilot on on |
| 25:03 | this final frontier of biology |
| 25:05 | appreciate it yeah appreciate you too |
| 25:07 | take care |
| 25:10 | [Music] |