Procyanidin C1 (PCC1)
Procyanidin C1 (PCC1) is a molecule found in grape (Vitis vinifera),[1] unripe apples,[2] and cinnamon.[3] It can be isolated from grape seed extract
[4] and is content in wine.
Procyanidin C1 has been shown to be an effective senolytic agent in wild-type mice, with effects of increased lifespan (+9.4%), reduced senescence markers and making them fitter. It was also found to greatly increase the effectiveness of chemotherapy in mice in which human prostate tumor cells were implanted.[5][6]
Studies
References
- ↑ Proanthocyanidin composition of red Vitis vinifera varieties from the Douro valley during ripening : Influence of cultivation altitude. Mateus Nuno, Marques Sara, Goncalves Ana C., Machado José M. and De Freitas Victor, American journal of enology and viticulture, 2001, vol. 52, no2, pp. 115-121, https://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1129642
- ↑ Nakano et al.; "Procyanidin C1 from Apple Extracts Inhibits FcεRI-Mediated Mast Cell Activation" , https://www.karger.com/Article/FullText/142044 , https://doi.org/10.1159/000142044
- ↑ Sun et al.; "Procyanidin C1, a Component of Cinnamon Extracts, Is a Potential Insulin Sensitizer That Targets Adipocytes" , https://doi.org/10.1021/acs.jafc.9b02932
- ↑ Carissa Wong et al.; "Grape seed chemical allows mice to live longer by killing aged cells" , https://www.newscientist.com/article/2300346-grape-seed-chemical-allows-mice-to-live-longer-by-killing-aged-cells/
- ↑ Carissa Wong et al.; "Grape seed chemical allows mice to live longer by killing aged cells" , https://www.newscientist.com/article/2300346-grape-seed-chemical-allows-mice-to-live-longer-by-killing-aged-cells/
- ↑ Xu et al.; "The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice" , https://doi.org/10.1038/s42255-021-00491-8