Area Under the Curve (AUC)

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Types

Type Description Application
  Area under the concentration-time curve up to the last measurable concentration. Used to determine the total exposure of the body to the drug until the last measurable concentration.
  Represents the total area under the concentration-time curve from administration to infinity. Provides an estimate of the total exposure of the body to a drug. Useful for evaluating the overall efficacy of a drug.
  Area under the concentration-time curve from the administration up to a specific time 't'. Useful for focusing on drug exposure within specific time windows.
  Area under the concentration-time curve from administration up to 24 hours. Often used when drugs are administered once a day.
  Area under the concentration-time curve over a dosing interval 'tau', for example in repeated dosing every 12 or 24 hours. Helpful in evaluating steady-state pharmacokinetics in multiple dosing regimens.
  Utilizes microdosing studies and mass spectrometric analyses to determine the AUC for drugs administered in very low concentrations. Suitable for studying the pharmacokinetics of drugs at subtherapeutic, micro-level doses.