Dr. David Sinclair's Supplement Protocol

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Substance Dose When Comment
Nicotinamide Mononucleotide (NMN) 1000 mg Morning
Resveratrol 1000 mg Morning Started taking it in his early 30s[1]
Metformin 800 mg Night, not when he making excercise the next day and muscles are growing
Spermidine 1000 mg Morning
Quercetin 500 mg Morning In [2] David mentoined that he took quercetin and fisetin around Jan 2022 for one month.
Fisetin 500 mg Morning
Vitamin D3 4,000 to 5,000 IUs
Vitamin K2 180 to 360 mcg
Vitamin Bs (B3, B6, B12) Variable Monitors Vitamin B levels with Inside Tracker because you want not too much and not too low
Low-Dose Aspirin 83 mg Night
Trimethylglycine (TMG) 500 - 1000 mg In a 2019 interview [3], David mentioned that he takes TMG as a precautionary measure, suggesting that excessive NMN supplementation might deplete the body's available methyl groups. However, only audio files of this interview remain, as the YouTube video was deleted. Notably, he hasn't mentioned TMG in any subsequent podcasts or videos, leading to the assumption that David might no longer be taking TMG.
Alpha Lipoic Acid (ALA) Night
Selenium By eating Brazil nuts
Satin Takes Satin since he was 29 because his cholesterol was way up (beyond 300) and his grandmother had a stroke in her 30s.
Coenzyme Q10 (coQ10) Night coQ10 is to make sure that the Satin doesn't deplete that too much
Omega 3-6-9 (fish oil)
Taurine 2000 mg

References

X = Taking, M = Taking in the morning, N = Taking at night, T = Taking temporarily
NMN Reseratrol Metformin Berberine Spermidine Quercetin Fisetin Vitamin D3 Vitamin K2 Vitamin Bs Low-Dose Aspirin TMG ALA Statin coQ10 Omega 3-6-9 Selenium Magnesium GABA L-Theanin Taurine
Lifespan: Why We Age – and Why We Don’t Have To Sept. 2019 X X X X X X
2021-12-27 - Interview Dr. David Sinclair - Huberman Lab Podcast - The Biology of Slowing & Reversing Aging Dec 2021 X X M
2022-01-26 - Podcast Dr. David Sinclair - NMN, NR, Resveratrol, Metformin & Other Longevity Molecules Jan 2022 X X N X X X
2022-05-03 - Interview Dr. David Sinclair - Knowledge Project - How to Not Die May 2022
2022-08-30 - Interview Dr. David Sinclair - Optimize Longevity - What To Eat & When For Longevity Aug 2022 X X X X X X N N X N X X
2022-08-31 - Interview Dr. David Sinclair - Optimize Longevity - Longevity Molecules and Supplements Aug 2022 X X X X T T
2022-09-02 - Interview Dr. David Sinclair - Optimize Longevity - Keeping Your Brain Young Sep 2022 X X X N N N
2023-07-17 - Interview Dr. David Sinclair - Optimize Longevity - Build Muscle & Maintain Longevity Jul 2023 N X X