Dr. David Sinclair
David Sinclair
David Andrew Sinclair (born 1969) is an Australian biologist and professor of genetics best known for his research on aging and longevity. He is a Professor at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. Sinclair is also a co-founder of several biotechnology companies and is known for his advocacy of using genetic and other therapies to combat aging.
Early Life and Education
David Sinclair was born in Australia in 1969. He received his Bachelor of Science (BSc) at the University of New South Wales (UNSW) in Sydney, Australia, where he also completed a Ph.D. in Molecular Genetics under the guidance of Ian Dawes, graduating in 1995. His doctoral research involved studies on gene regulation in yeast, which is a model organism in aging research due to its short lifespan and well-documented genome.
Career and Research
After completing his Ph.D., Sinclair received a postdoctoral fellowship at the Massachusetts Institute of Technology (MIT) in the lab of Leonard Guarente, where he studied the role of sirtuins in aging, particularly the yeast protein Sir2 which was linked to the regulation of lifespan in several model organisms. His research has contributed to the understanding of how sirtuins are activated by the compound resveratrol, found in red wine, which has been associated with extended lifespan in animal models.
Sinclair joined the faculty of Harvard Medical School in the early 2000s. His research group focuses on understanding the biological mechanisms of aging and developing new interventions to slow its process. They have identified several chemical compounds, including the NAD+ precursor nicotinamide mononucleotide (NMN), that appear to mitigate some effects of aging in animal models.
Sirtuins in Aging
Sinclair's research has significantly focused on the sirtuin family of protein deacetylases, which are thought to be responsible for the lifespan-extending properties of diets such as caloric restriction in various species. His lab has published extensively on the biochemistry of sirtuins and their role in DNA repair, metabolism, and mitochondrial function, among other cellular processes critical to the aging pathway.
NAD+ and Aging
Another major focus of Sinclair's research is the role of NAD+ (nicotinamide adenine dinucleotide) in aging. NAD+ is a coenzyme found in all living cells that is involved in redox reactions. Sinclair's lab has shown that NAD+ levels decline with age in various organisms and that supplementing older mice with an NAD+ precursor can rejuvenate aspects of aging at a cellular and physiological level.
Public Advocacy and Business Ventures
Beyond his academic research, David Sinclair is an advocate for translating aging research into medical applications. He has co-founded several biotechnology companies, including Sirtris Pharmaceuticals, which focused on resveratrol formulations and sirtuin-activating compounds, and was later acquired by GlaxoSmithKline. He is also involved with companies working on NAD+ boosting molecules and other technologies meant to combat aging.
Sinclair is the author of the book Lifespan: Why We Age—and Why We Don't Have To, published in September 2019, where he discusses his view of aging as a disease that can be treated to extend human healthspan and lifespan.
Awards and Recognition
Sinclair has received numerous awards for his research on aging. Some of his accolades include the Australian Commonwealth Prize, the American Association for Aging Research’s Innovator Award, and being named to Time Magazine’s list of the "100 most influential people" in the world.
David is vegan since at least December 2021 [1].
David Sinclair's Protocol
Videos
Produced by David Sinclair
Podcasts
- 2022-01-05 - Podcast Dr. David Sinclair - The Science Behind Why We Age
- 2022-01-12 - Podcast Dr. David Sinclair - What to Eat & When to Eat for Longevity
- 2022-01-19 - Podcast Dr. David Sinclair - Exercise, Heat, Cold & Other Stressors for Longevity
- 2022-01-26 - Podcast Dr. David Sinclair - NMN, NR, Resveratrol, Metformin & Other Longevity Molecules
- 2022-02-02 - Podcast Dr. David Sinclair - Medical Interventions (TRT, HGH, Stem Cells, etc.) For Longevity
- 2022-02-09 - Podcast Dr. David Sinclair - The Science of Looking Younger, Longer
- 2022-02-16 - Podcast Dr. David Sinclair - The Science of Keeping the Brain Healthy
- 2022-02-23 - Podcast Dr. David Sinclair - Biotracking, Age Reversal & Other Advanced Health Technologies
Longevity Lifestyle Series with Serena Poon
In August 2022 David Sinclair and Serena Poon startet the Optimize Longevity YouTube Channel that is all about tips for improving the quality of life and extending the lifespan.
Season 1
- 2022-08-28 - Interview Dr. David Sinclair - Optimize Longevity - Aging: DNA is not your destiny. Food is
- 2022-08-30 - Interview Dr. David Sinclair - Optimize Longevity - What To Eat & When For Longevity
- 2022-08-31 - Interview Dr. David Sinclair - Optimize Longevity - Longevity Molecules and Supplements
- 2022-09-01 - Interview Dr. David Sinclair - Optimize Longevity - The Science of Looking Younger Longer
- 2022-09-02 - Interview Dr. David Sinclair - Optimize Longevity - Keeping Your Brain Young
Season 2
- 2023-05-03 - Interview Dr. David Sinclair - Optimize Longevity - Personalizing Your Fasting Window
- 2023-05-13 - Interview Dr. David Sinclair - Optimize Longevity - Gut Health for Longevity
- 2023-05-19 - Interview Dr. David Sinclair - Optimize Longevity - Ask Us Anything
Season 3
Interviews and Talks
- 2019-09-01 - Interview Dr. David Sinclair - Dr. Mercola interviews Dr. David Sinclair on Extending Your "Lifespan"
- 2020-01-30 - Talk Dr. David Sinclair - IVY Masterclass - How to Extend Your Lifespan with David Sinclair
- 2021-06-07 - Interview Dr. David Sinclair - Lex Fridman Podcast - Extending the Human Lifespan Beyond 100 Years
- 2021-12-27 - Interview Dr. David Sinclair - Huberman Lab Podcast - The Biology of Slowing & Reversing Aging
- 2021-12-31 - Interview Dr. David Sinclair - mindbodygreen - How to look & feel 15 years younger
- 2022-01-14 - Interview Dr. David Sinclair - Reverse Your Age: What To Eat & When To Eat For LONGEVITY
- 2022-02-11 - Interview Dr. David Sinclair - REVERSE AGING: What To Eat & When To Eat To INCREASE LONGEVITY
- 2022-05-03 - Interview Dr. David Sinclair - Knowledge Project - How to Not Die
- 2022-06-09 - Interview Dr. David Sinclair - Tom Bilyeu - The DAILY HACKS To Look Younger, Live Longer & REVERSE YOUR AGE
- 2022-10-24 - Presentation Dr. David Sinclair - ARDD2022 - Great release of unpublished data from David Sinclair's Lab
- 2022-12-29 - Interview Dr. David Sinclair - Moonshots and Mindsets - Why Aging is a Disease With David Sinclair
- 2022-12-29 - Interview Dr. David Sinclair - Moonshots with Peter Diamandis - Age Reversal Breakthroughs, FDA Approval, and Living Forever
- 2023-03-18 - Interview Dr. David Sinclair - India Today - Exclusive Conversation With Geneticist & Harvard Professor David Sinclair
- 2023-06-26 - Interview Dr. David Sinclair - The Longevity Experts - Why We Don't Have to Age & How to Fight Aging
- 2023-07-02 - Interview Dr. David Sinclair - The Longevity Experts - The Harvard Scientist's Anti-Aging Protocol
- 2023-07-04 - Interview Dr. David Sinclair - The Longevity Experts - Aging is NOT Unstoppable (2023 Edition)
- 2023-07-14 - Interview Dr. David Sinclair - mindbodygreen - AGING is a disease we can REVERSE
- 2023-07-19 - Talk Dr. David Sinclair - BIOHACK 2.0 - How To Live LONGER & AGE BETTER
- 2023-07-22 - Interview Dr. David Sinclair - Reversing Aging: The Revolutionary Discoveries of David Sinclair
- 2023-08-24 - Interview Dr. David Sinclair - Aging is Now Optional