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Nicotinamide (NAM): Difference between revisions
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* Nicotinamide (NAM) and nicotinic acid (NA) are already available on the world market as dietary supplements. However, high oral doses of NAM and NA have been reported to be hepatotoxic to humans <ref>Ito TK, et al. A single oral supplementation of nicotinamide within the daily tolerable upper level increases blood NAD+ levels in healthy subjects. Transl. Med. Aging. 2021;5:43–51. doi: 10.1016/j.tma.2021.09.001.</ref>{{pmid|11126400}}, and an adverse effect of vasodilative flushing due to high NA intake has been shown{{pmid|22646128}}. The upper tolerable dose of NAM and NA for humans established by the European Commission and the UK Vitamin and Mineral Expert are 900 mg/day and 10 mg/day, respectively<ref>Scientific Committee on Food. ''Tolerable Upper Intake Levels for Vitamin S and Minerals'' (2006). <nowiki>https://www.efsa.europa.eu/sites/default/files/efsa_rep/blobserver_assets/ndatolerableuil.pdf</nowiki>.</ref>. | * Nicotinamide (NAM) and nicotinic acid (NA) are already available on the world market as dietary supplements. However, high oral doses of NAM and NA have been reported to be hepatotoxic to humans <ref>Ito TK, et al. A single oral supplementation of nicotinamide within the daily tolerable upper level increases blood NAD+ levels in healthy subjects. Transl. Med. Aging. 2021;5:43–51. doi: 10.1016/j.tma.2021.09.001.</ref>{{pmid|11126400}}, and an adverse effect of vasodilative flushing due to high NA intake has been shown{{pmid|22646128}}. The upper tolerable dose of NAM and NA for humans established by the European Commission and the UK Vitamin and Mineral Expert are 900 mg/day and 10 mg/day, respectively<ref>Scientific Committee on Food. ''Tolerable Upper Intake Levels for Vitamin S and Minerals'' (2006). <nowiki>https://www.efsa.europa.eu/sites/default/files/efsa_rep/blobserver_assets/ndatolerableuil.pdf</nowiki>.</ref>. | ||
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