Nicotinamide Mononucleotide (NMN): Difference between revisions

Nicotinamide Mononucleotide (NMN) (view source)

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 #Nicotinamide is then methylated by the liver to form N1-methylnicotinamide, which can be excreted in the urine. This methylation process consumes a methyl group from [[S-adenosylmethionine (SAMe)]], the primary methyl donor in the body.
-The potential concern is that excessive NMN supplementation might lead to a decrease in the body's available methyl groups, which play crucial roles in various biological processes including DNA methylation and neurotransmitter synthesis.
+There could be a compensatory mechanisms that if methyl groups were being depleted at a concerning rate, the body would likely slow down the conversion of NMN to NAD+ or the methylation of nicotinamide. If not, there is a potential concern is that excessive NMN supplementation might lead a [[Methyl Donor Deficiency]] to a decrease in the body's available methyl groups, which play crucial roles in various biological processes including DNA methylation and neurotransmitter synthesis.
-For that reason, some individuals who take NMN also supplement with [[Trimethylglycine (TMG)]], a [[Methyl Donors|methyl donor]], to ensure that they are not depleting their body's methyl groups. However, this is a precautionary measure and not necessarily based on concrete evidence. [[NOVOS]] use B vitamins and phosphatidylcholine as methyl donors in their product to avoid the side effects of TMG and because they think that TMG is already too deep into the methylation pathways, not allowing the body to choose the amount of methylation for itself. <ref>https://novoslabs.com/frequently-asked-questions/nmn-nicotinamide-mononucleotide/do-you-need-to-combine-nmn-with-tmg-trimethylglycine/</ref>
+For that reason, some individuals who take NMN also supplement with [[Methyl Donors|methyl donors]] like [[Trimethylglycine (TMG)]] to ensure that they are not depleting their body's methyl groups. However, this is a precautionary measure and not necessarily based on concrete evidence.
-However, there are a few important points to consider:
+However, there is '''no clear evidence yet'''. While the pathway is known, the actual significance of NMN supplementation on global methyl group status is not well-established in humans. It's a theoretical concern, and it would require substantial NMN consumption to have a significant impact as well as the comsumption of methyl donors in the diet would be too low to replenish methyl groups.
-#'''No clear evidence yet''': While the pathway is known, the actual significance of NMN supplementation on global methyl group status is not well-established in humans. It's a theoretical concern, and it would require substantial NMN consumption to have a significant impact.
-#'''Compensatory mechanisms''': The human body has various feedback mechanisms. If methyl groups were being depleted at a concerning rate, the body would likely slow down the conversion of NMN to NAD+ or the methylation of nicotinamide.
-#'''Methyl donors in diet''': Many people consume methyl donors like choline, betaine, and folate in their diets. These can help replenish methyl groups.
 ===Risks of NMN Supplementation===