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Nicotinamide Mononucleotide (NMN): Difference between revisions
Nicotinamide Mononucleotide (NMN) (view source)
Revision as of 01:58, 6 November 2023
, 6 November 2023→Combining NMN with Methyl Donors
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===Combining NMN with Methyl Donors=== | ===Combining NMN with Methyl Donors=== | ||
There | There is a theoretical concern that consuming NMN could deplete [[Methyl Donors|methyl groups]] in the body. This is because NMN is converted to NAD+ in the body, which can then be broken down into nicotinamide. Nicotinamide is then methylated by the liver to form N1-methylnicotinamide, which is excreted in the urine. This methylation process consumes a methyl group from [[S-adenosylmethionine (SAMe)]], the primary methyl donor in the body. | ||
There could be a compensatory mechanisms that if methyl groups were being depleted at a concerning rate, the body would likely slow down the conversion of NMN to NAD+ or the methylation of nicotinamide. If not, there is a potential concern is that excessive NMN supplementation might lead a [[Methyl Donor Deficiency]] to a decrease in the body's available methyl groups, which play crucial roles in various biological processes including DNA methylation and neurotransmitter synthesis. | There could be a compensatory mechanisms that if methyl groups were being depleted at a concerning rate, the body would likely slow down the conversion of NMN to NAD+ or the methylation of nicotinamide. If not, there is a potential concern is that excessive NMN supplementation might lead a [[Methyl Donor Deficiency]] to a decrease in the body's available methyl groups, which play crucial roles in various biological processes including DNA methylation and neurotransmitter synthesis. | ||