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Nicotinamide Mononucleotide (NMN): Difference between revisions
Nicotinamide Mononucleotide (NMN) (view source)
Revision as of 18:57, 6 November 2023
, 6 November 2023→Combining NMN with Methyl Donors
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There could be a compensatory mechanisms that if methyl groups were being depleted at a concerning rate, the body would likely slow down the conversion of NMN to NAD+ or the methylation of nicotinamide. If not, there is a potential concern that excessive NMN supplementation might lead to a [[Methyl Donor Deficiency]] associated with low energy and tiredness, among other things. | There could be a compensatory mechanisms that if methyl groups were being depleted at a concerning rate, the body would likely slow down the conversion of NMN to NAD+ or the methylation of nicotinamide. If not, there is a potential concern that excessive NMN supplementation might lead to a [[Methyl Donor Deficiency]] associated with low energy and tiredness, among other things. | ||
For that reason, some individuals who take NMN also supplement with [[Methyl Donors|methyl donors]] like [[Trimethylglycine (TMG)]] to ensure that they are not depleting their body's methyl groups. While some individuals are taking | For that reason, some individuals who take NMN also supplement with [[Methyl Donors|methyl donors]] like [[Trimethylglycine (TMG)]] to ensure that they are not depleting their body's methyl groups. While some individuals are taking methyl donors as a precautionary measure, others add them to their daily regime after feeling sleepiness by NMN.<ref>https://renuebyscience.com/forums/viewtopic.php?t=2575</ref> | ||
However, there is no clear evidence yet as clinical trails are missing. While the pathway is known, the actual significance of NMN supplementation on global methyl group status is not well-established in humans. It would require substantial NMN consumption to have a significant impact coupled with insufficient intake of dietary methyl donors to replenish these groups. | However, there is no clear evidence yet as clinical trails are missing. While the pathway is known, the actual significance of NMN supplementation on global methyl group status is not well-established in humans. It would require substantial NMN consumption to have a significant impact coupled with insufficient intake of dietary methyl donors to replenish these groups. | ||