Nicotinamide Mononucleotide (NMN): Difference between revisions

Nicotinamide Mononucleotide (NMN) (view source)

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 A recent RCT clinial trial investigated the effects of the time-dependent intake of NMN (250 mg/day) on older adults (≥ 65 years) over 12 weeks. Aging-induced insufficient physical activity and deterioration of physical function result in fatigue. This symptom frequently occurs among the elderly and has been complained by 27–50% of community-dwelling older adults in their daily life. Overall, NMN intake in the afternoon (in contrast to the morning) effectively improved lower limb function and reduced drowsiness in older adults. These findings suggest the potential of NMN in preventing loss of physical performance and improving fatigue in older adults.{{pmid|35215405}}
-===Combining NMN with Methyl Donors===
+=== Combining NMN with Methyl Donors ===
-There is a theoretical concern that consuming NMN could deplete [[Methyl Donors|methyl groups]] in the body. This is because NMN is converted to NAD+ in the body, which can then be broken down into nicotinamide. Nicotinamide is then methylated by the liver to form N1-methylnicotinamide, which is excreted in the urine. This methylation process consumes a methyl group from [[S-adenosylmethionine (SAMe)]], the primary methyl donor in the body.
+There is a theoretical concern that consuming NMN could deplete [[Methyl Donors|methyl groups]] in the body. NMN is converted to NAD+ in the body, which can then be broken down into nicotinamide. Nicotinamide is then methylated by the liver to form N1-methylnicotinamide, which is excreted in the urine. This methylation process consumes a methyl group from [[S-adenosylmethionine (SAMe)]], the primary methyl donor in the body.
-There could be a compensatory mechanisms that if methyl groups were being depleted at a concerning rate, the body would likely slow down the conversion of NMN to NAD+ or the methylation of nicotinamide. If not, there is a potential concern that excessive NMN supplementation might lead to a [[Methyl Donor Deficiency]] associated with low energy and tiredness, among other things.
+There could be compensatory mechanisms in place; if methyl groups were being depleted at a concerning rate, the body would likely slow down the conversion of NMN to NAD+ or the methylation of nicotinamide. If not, the potential concern is that excessive NMN supplementation might lead to a [[Methyl Donor Deficiency]] associated with symptoms such as low energy and tiredness.
-For that reason, some individuals who take NMN also supplement with [[Methyl Donors|methyl donors]] like [[Trimethylglycine (TMG)]] to ensure that they are not depleting their body's methyl groups. While some individuals are taking methyl donors as a precautionary measure, others add them to their daily regime after feeling sleepiness by NMN.<ref>https://renuebyscience.com/forums/viewtopic.php?t=2575</ref>
+For this reason, some individuals who take NMN also supplement with [[Methyl Donors|methyl donors]] such as [[Trimethylglycine (TMG)]] to ensure that they are not depleting their body's supply of methyl groups. Some individuals take methyl donors as a precautionary measure, while others may begin supplementation after experiencing sleepiness attributed to NMN.<ref>https://renuebyscience.com/forums/viewtopic.php?t=2575</ref>
-However, there is no clear evidence yet as clinical trails are missing. While the pathway is known, the actual significance of NMN supplementation on global methyl group status is not well-established in humans. It would require substantial NMN consumption to have a significant impact coupled with insufficient intake of dietary methyl donors to replenish these groups.
+However, there is no clear evidence yet as clinical trials are lacking. While the biochemical pathway is known, the actual impact of NMN supplementation on the global status of methyl groups is not well-established in humans. It would likely require substantial NMN consumption coupled with an insufficient intake of dietary methyl donors to significantly affect these groups.
 ===Risks of NMN Supplementation===