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Nicotinamide Mononucleotide (NMN): Difference between revisions
Nicotinamide Mononucleotide (NMN) (view source)
Revision as of 19:04, 6 November 2023
, 6 November 2023→Combining NMN with Methyl Donors
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There could be compensatory mechanisms in place; if methyl groups were being depleted at a concerning rate, the body would likely slow down the conversion of NMN to NAD+ or the methylation of nicotinamide. If not, the potential concern is that excessive NMN supplementation might lead to a [[Methyl Donor Deficiency]] associated with symptoms such as low energy and tiredness. | There could be compensatory mechanisms in place; if methyl groups were being depleted at a concerning rate, the body would likely slow down the conversion of NMN to NAD+ or the methylation of nicotinamide. If not, the potential concern is that excessive NMN supplementation might lead to a [[Methyl Donor Deficiency]] associated with symptoms such as low energy and tiredness. | ||
For this reason, some individuals who take NMN also supplement with [[Methyl Donors|methyl donors]] such as [[Trimethylglycine (TMG)]] to ensure that they are not depleting their body's supply of methyl groups. Some individuals take methyl donors as a precautionary measure, while others may begin supplementation after experiencing sleepiness attributed to NMN.<ref>https://renuebyscience.com/forums/viewtopic.php?t=2575</ref> | For this reason, some individuals who take NMN also supplement with [[Methyl Donors|methyl donors]] such as [[Trimethylglycine (TMG)]] or [[Vitamin B Complex]] to ensure that they are not depleting their body's supply of methyl groups. Some individuals take methyl donors as a precautionary measure, while others may begin supplementation after experiencing sleepiness attributed to NMN.<ref>https://renuebyscience.com/forums/viewtopic.php?t=2575</ref> | ||
However, there is no clear evidence yet as clinical trials are lacking. While the biochemical pathway is known, the actual impact of NMN supplementation on the global status of methyl groups is not well-established in humans. It would likely require substantial NMN consumption coupled with an insufficient intake of dietary methyl donors to significantly affect these groups. | However, there is no clear evidence yet as clinical trials are lacking. While the biochemical pathway is known, the actual impact of NMN supplementation on the global status of methyl groups is not well-established in humans. It would likely require substantial NMN consumption coupled with an insufficient intake of dietary methyl donors to significantly affect these groups. | ||