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Bioavailability: Difference between revisions
→Absolute Bioavailability
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This measures the bioavailability of a drug compared to its intravenous administration. The formula for calculating absolute bioavailability (F) is: | This measures the bioavailability of a drug compared to its intravenous administration. The formula for calculating absolute bioavailability (F) is: | ||
<math>F = \frac{AUC_{\text{oral}} \times Dose_{\text{IV}}}{AUC_{\text{IV}} \times Dose_{\text{oral}}} \times 100\%</math> | :<math>F = \frac{AUC_{\text{oral}} \times Dose_{\text{IV}}}{AUC_{\text{IV}} \times Dose_{\text{oral}}} \times 100\%</math> | ||
where AUC is the area under the plasma concentration-time curve for oral (AUC<sub>oral</sub>) and intravenous (AUC<sub>IV</sub>) administration, and Dose refers to the dose administered via each route. | where AUC is the area under the plasma concentration-time curve for oral (AUC<sub>oral</sub>) and intravenous (AUC<sub>IV</sub>) administration, and Dose refers to the dose administered via each route. | ||