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2021-12-31 - Interview Dr. David Sinclair - mindbodygreen - How to look & feel 15 years younger: Difference between revisions

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2021-12-31 - Interview Dr. David Sinclair - mindbodygreen - How to look & feel 15 years younger (view source)

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== Transcript ==
== Transcript ==
david welcome
=== democratizing longevity ===
 
{| style="padding-top: 1em;"
hey jason it's great to see you great to
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| david welcome hey jason it's great to see you great to have you back on the show and
have you back on the show and
|-
 
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 0:06
it was so awesome to see you mentioned
| it was so awesome to see you mentioned in our wellness trends specifically
 
|-
in our wellness trends specifically
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 0:11
 
| around longevity and something we're particularly excited about and you're excited about is this
around longevity
|-
 
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and something we're particularly excited
| idea of democracization you know when people tend to think of longevity
 
|-
about and you're excited about is this
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| they tend to think of really expensive tests and potential potentially pharmaceuticals and
idea of democracization
|-
 
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 0:29
you know
| supplements and so on they think of silicon valley and billionaires and all that crazy stuff you read
 
|-
when people tend to think of longevity
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| but let's take a step back and and talk about democratizing longevity and i'm curious you know what is democratizing
they tend to think of
|-
 
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really expensive tests and potential
| longevity mean to you yeah well you're right that there is a group of
 
|-
potentially pharmaceuticals and
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| individuals that i meet more and more often that have the means and the wealth and
supplements and so on they think of
|-
 
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silicon valley and billionaires and all
| the connections to extend their lifespan i think by 20 30 years
 
|-
that crazy stuff you read
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 1:00
 
| but it's a small group of people and what we need to do is to give that that information
but let's take a step back and and talk
|-
 
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about democratizing longevity and i'm
| to everybody and that involves not just making it available but truly being educational
 
|-
curious you know what is democratizing
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| and interesting and so what i've decided to do with my career as this harvard professor from a lab
longevity mean to you yeah well you're
|-
 
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right that there is a group of
| is to use hopefully decent abilities at storytelling to educate people and make
 
|-
individuals that
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 1:25
 
| it interesting i have a podcast coming out early next year january 5th where
i meet more and more often
|-
 
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 1:30
that have the means and the wealth and
| hopefully it's an interesting uh journey through the longevity world of
 
|-
the connections
| style="min-width:4em; color: grey; text-align: right; padding-right: 1em; vertical-align: top;" | 1:35
 
| science and nutrition and and exercise but also supplements and
to extend their lifespan i think by
|-
 
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20 30 years
| some of the more far out things that these billionaires are into and so it's
 
but it's a small group of people
 
and what we need to do is to give
 
that that information
 
to everybody and that involves not just
 
making it available but truly
 
being educational
 
and interesting and so what i've
 
decided to do with my career as this
 
harvard professor from a lab
 
is to use hopefully decent abilities at
 
storytelling to educate people and make
 
it interesting i have a podcast coming
 
out early next year january 5th where
 
hopefully it's an
 
interesting uh
 
journey through the longevity world of
 
science and
 
nutrition and and exercise but also
 
supplements and
 
some of the more far out things that
 
these billionaires are into and so it's
 
about education primarily but the second
 
part of that that i'm very into and
 
driven by is to make
 
the
 
medicines that will come out of this
 
field of aging research available to
 
everybody
 
uh because if it's just for the rich and
 
it's cost a hundred thousand dollars
 
treatment then that's really not going
 
to help me achieve my goal in life which
 
is to really make millions
 
hopefully billions of people live
 
healthier lives and in doing so lengthen
 
their life as well
 
and so the science that we do and the
 
drug developments on i've started about
 
a dozen companies now the companies are
 
very focused on making those drugs
 
are cheaply and widely available
 
and the kind of technologies for the
 
most part
 
are
 
drugs that could be just a few cents a
 
day once they
 
eventually uh get widely used
 
what do you think was the biggest update
 
that impacted our understanding
 
of longevity in the last year you're on
 
top of everything
 
what's been interesting to you over the
 
course of the last year
 
yeah
 
well
 
what's actually happening in society is
 
super interesting i used to be uh the
 
pariah of biology i'm so sure harvard
 
wanted to kick me out a few times
 
but there's been a real shift both in
 
mentality of doctors and researchers and
 
the public
 
that aging is something
 
that is more akin to a medical condition
 
a disease and that it's treatable so
 
there's this zeitgeist mega trend if you
 
want to call it in society that's
 
changed but in terms of research and
 
breakthroughs a really big one and
 
forgive me for focusing on myself for
 
one second my lab and the research team
 
and our collaborators a year ago exactly
 
to the day almost that
 
we could reset the body in terms of age
 
go back by about 80
 
and do a permanent reset of the body now
 
this is in animals but these are mice
 
that are very similar biologically to us
 
and we've done it now in human cells and
 
human
 
tissue so we're optimistic that the same
 
principles that i'm going to tell you
 
about in mice apply to humans and that
 
is that we have a backup copy of youth
 
in our bodies that can be accessed we're
 
now using gene therapy because that's
 
what we know works but we're hoping
 
uh to find natural molecules that will
 
achieve the same result to not just slow
 
down the aging process which we know we
 
can do by eating well at a training kind
 
of diet and exercising lose your breath
 
a few times a week at least
 
but by actually taking a supplement that
 
would reset the body within a matter of
 
a few months to go back
 
not just by six months but
 
many many years
 
and i truly believe that's going to be
 
possible in the next five to 10 years
 
and our goal now is as a society is to
 
stay alive until these discoveries
 
become mainstream
 
and so you you think we're five or so
 
years out from having that smart drug if
 
you will or
 
that
 
we can take and that alone will extend
 
health span
 
yeah i know it sounds crazy right
 
unfortunately i'm at harvard so people
 
tend to take me a little more seriously
 
but
 
the big
 
breakthrough was the discovery that we
 
have this backup copy
 
of
 
youthfulness
 
the easy part is figuring out how to
 
reset the system it's similar if you
 
want to use the analogy of the wright
 
brothers i know it's used a little too
 
much but it it works the wright brothers
 
the hard part was figuring out how to
 
glide around
 
the dunes strapping on the engine flying
 
eventually transcontinental flight now
 
global that's just extensions of what
 
they did in kitty hawk
 
and we basically in aging we've done
 
that now we know how to fly
 
and now we're going to strap on the
 
engine and see
 
how quickly and how cheaply we can do
 
this so i'm quite confident that we will
 
find molecules that will do this in fact
 
there was a paper that just came out
 
that shows a natural molecule called
 
alpha ketoglutarate
 
that i predicted in my book lifespan
 
probably would work
 
was able to reset the age
 
of 40 people i think out of 42 people 40
 
people had their biological age reversed
 
by an average of eight years
 
within just
 
uh under a year of taking this
 
supplement so akg
 
right and we can take that that is
 
currently a supplement that's out there
 
or can it be found in food naturally or
 
where can we find it i think a lot of
 
people are going to be very intrigued
 
yeah
 
me too like like most of these molecules
 
that plants make in response to stress
 
these molecules are called xenohermetins
 
that we name them that
 
they uh
 
you need to
 
a lot of them a lot of plants to get the
 
amounts that
 
are medicinal and so i it's better to
 
eat a purified source of it you can buy
 
akg or of ketoglutarate on the internet
 
i look for trust and supplier
 
very high quality high
 
content of alfie kimku right there are
 
some companies that are selling it that
 
are combinations with vitamins in the
 
case of this human study that's what
 
they sell but yeah it's widely available
 
and it would be really quite a thing for
 
humanity to have a safe molecule that's
 
similar to an amino acid that we could
 
just pop and if it's true take our years
 
our age back by half a decade or a
 
decade now i'm quite skeptical because
 
it sounds way too good to be true
 
but then again some things are true so
 
we're going to repeat the experiment
 
and see what happens but i will say that
 
the reason i think it's it's plausible
 
is that if you give alpha ketoglutarate
 
to yeast cells that make beer and bread
 
to fruit flies and to mice they also
 
live longer so there's something really
 
important going on here
 
building off of akg
 
resveratrol you've always been a fan of
 
resveratrol in many ways i feel like you
 
put resveratrol on the map are you still
 
a fan of resveratrol in terms of
 
supplementation and in terms of some of
 
the magic can do in terms of our
 
longevity
 
well i i am since we first made this
 
discovery in 2003
 
or there are something like 5 000 papers
 
showing that it's beneficial to cells
 
human cells and animal studies and and
 
even now there's about a dozen
 
positive human studies with resveratrol
 
now the downside of resveratrol is that
 
you cannot get it from red wine you'd
 
need to drink 200 glasses a day and that
 
even when you buy it purified
 
it's it's insoluble so if you put a
 
spoonful of resveratrol which i did take
 
every morning into water it'll sink to
 
the bottom
 
so you need to mix it with something i i
 
have a low-fat yogurt i recently am
 
doing vegan yogurts
 
which work well coconut base or with a
 
bit of olive oil which
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