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Interventions Testing Program (ITP): Difference between revisions
Interventions Testing Program (ITP) (view source)
Revision as of 04:54, 18 November 2023
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=== Agent Testing === | === Agent Testing === | ||
Up to six agents are accepted each year, tested simultaneously under standard operating procedures at the three participating sites. Tests are conducted on genetically heterogeneous UM-HET3 mice, including initial pilot testing, followed by Stage I and Stage II testing, focusing on lifespan, health, pathology, and biochemical mechanisms. | Up to six agents are accepted each year, tested simultaneously under standard operating procedures at the three participating sites. Tests are conducted on genetically heterogeneous UM-HET3 mice, including initial pilot testing, followed by Stage I and Stage II testing, focusing on lifespan, health, pathology, and biochemical mechanisms. | ||
== Identified Compounds == | |||
Over the years, the Interventions Testing Program (ITP) has made significant discoveries by identifying nine agents that have been shown to increase the median lifespan in their test subjects. These compounds, along with the key references to their discovery, are as follows: | |||
* '''Acarbose:''' Identified in multiple studies (Harrison 2014, Strong 2016, Harrison 2019), acarbose has been shown to extend lifespan. It is primarily used in the medical field to treat type 2 diabetes by inhibiting enzymes that digest carbohydrates, thereby reducing glucose absorption. | |||
* '''Aspirin:''' Aspirin was found to have lifespan-extending properties as reported in Strong 2008. Commonly known for its use as a pain reliever and anti-inflammatory, its role in longevity research adds a new dimension to its therapeutic potential. | |||
* '''Canagliflozin:''' Identified in Miller 2020, canagliflozin is primarily used to treat type 2 diabetes. It works by inhibiting the sodium-glucose transport protein, which helps to reduce blood sugar levels. | |||
* '''Captopril:''' Discovered to increase lifespan in Strong 2022, captopril is typically employed as a treatment for hypertension and certain types of heart failure. | |||
* '''Glycine:''' This simple amino acid was shown to have life-extending effects in Miller 2019. Glycine has various roles in the body, including as a neurotransmitter and a building block for proteins. | |||
* '''Nordihydroguaiaretic Acid (NDGA):''' NDGA's impact on lifespan was reported in Strong 2008 and Strong 2016. It is a plant-derived compound known for its antioxidant properties. | |||
* '''Protandim®:''' This patented dietary supplement was indicated to increase lifespan in Strong 2016. It is composed of a blend of herbal ingredients and is marketed for its antioxidant benefits. | |||
* '''Rapamycin:''' One of the most significant findings of the ITP, rapamycin has been consistently identified in multiple studies (Harrison 2009, Miller 2011, Wilkinson 2012, Miller 2014) as a compound that extends lifespan. Originally developed as an immunosuppressant, rapamycin has gained attention for its potential anti-aging properties. | |||
* '''17α-Estradiol:''' Found to increase lifespan in Harrison 2014, Strong 2016, and Harrison 2021, 17α-Estradiol is a stereoisomer of the hormone estradiol and has shown promise in age-related research. | |||
Each of these compounds has contributed to our understanding of aging and longevity, providing valuable insights into potential therapeutic approaches for extending healthy life. | |||
== See Also == | == See Also == | ||